2019
DOI: 10.1038/s41598-019-52404-1
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Metabolite Profiling and Quantitation of Cucurbitacins in Cucurbitaceae Plants by Liquid Chromatography coupled to Tandem Mass Spectrometry

Abstract: Cucurbitaceae is an important plant family because many of its species are consumed as food, and used in herbal medicines, cosmetics, etc. It comprises annual vines and is rich in various bioactive principles which include the cucurbitacins. These steroidal natural products, derived from the triterpene cucurbitane, are mainly the bitter principles of the family Cucurbitaceae. Their biological activities include anti-inflammatory, hepatoprotective, and anti-cancer activities. A total of 10 species belonging to … Show more

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Cited by 25 publications
(8 citation statements)
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“…From Table 1, two amino acids (phenylalanine and tryptophan) and four fatty acids (linolenic acid, 10-nonadecenoic acid, linoelaidic acid, and trans -vaccenic acid) 27–29 were detected in SRP, and these were also found in nutritional value tests. One alkaloid (feruloyltyramine), 19 one terpenoid (bryoamaride), 30 and one coumarin (hydrangenol) 31 were identified in this species. Emodin also was found in SRP.…”
Section: Resultsmentioning
confidence: 84%
“…From Table 1, two amino acids (phenylalanine and tryptophan) and four fatty acids (linolenic acid, 10-nonadecenoic acid, linoelaidic acid, and trans -vaccenic acid) 27–29 were detected in SRP, and these were also found in nutritional value tests. One alkaloid (feruloyltyramine), 19 one terpenoid (bryoamaride), 30 and one coumarin (hydrangenol) 31 were identified in this species. Emodin also was found in SRP.…”
Section: Resultsmentioning
confidence: 84%
“…The identification of these compounds was accomplished through a rigorous process involving the comparison of their mass-to-charge ratios (m/z) and the fragmentation patterns generated by MS/MS analysis. These data were meticulously matched with established databases, including the Dictionary of Natural Compounds and data from literature [24][25][26][27][28].…”
Section: Chemical Profiling Of Bitter Gourd Fruits Based On Diverse A...mentioning
confidence: 99%
“…Chemical profiling of the most effective Bitter gourd fruit cultivars (Palee and Good healthy) show that these cultivars contain higher compound intensities of the triterpenoids Xuedanoside H, Karaviloside IX and Acutoside A compared to the less effective fruit cultivars (Wild type, HMT242 and Bilai). These triterpenoids have previously been identified in Bitter gourd [24][25][26][27][28]. Xuedanoside H is a phenolic glycoside derivate which is known to be a SGLT2 inhibitor [34,35].…”
Section: Plos Onementioning
confidence: 99%
“…Furthermore, a special kind of cucurbitacins from the Cucurbitaceae family called momordicosides can be found in the Momordica charantia (bitter melon or African cucumber). Cucurbitacins have diverse therapeutically important and attractive bioactivities, including in cancer chemoprevention/chemotherapy, and numerous preclinical studies have proven these properties (Table 1 ) [ 25 27 ].…”
Section: Cucurbitacins: Origin Traditional Uses and Therapeutic Poten...mentioning
confidence: 99%