Metabolite profiling, antioxidant and anti-aging activities of Siraitia grosvenorii pomace processed by solid-state fermentation with Eurotium cristatum

Yin, Jiaquan; Liu, Xinyi; Peng, Fangyi; Wang, Qixiang; Xiao, Yu; Liu, Suchun

doi:10.1016/j.procbio.2023.08.016

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…E. cristatum fermentation has shown to increase contents of soluble dietary fiber and phytochemicals compared with raw materials, thus leading to increased functional activities. − Such benefits might be due to the functionality of E. cristatum polysaccharides or the capacity of E.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of Eurotium cristatum Fermented Thinned Young Apple and Mechanisms Underlying Its Alleviating Impacts on Experimental Colitis

Song,

Zhou,

Liu

et al. 2024

J. Agric. Food Chem.

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A hundred million tons of young apples are thinned and discarded in the orchard per year, aiming to increase the yield and quality of apples. We fermented thinned young apples using a potential probiotic fungus, Eurotium cristatum, which notably disrupted the microstructure of raw samples, as characterized by the scanning electron microscope. Fermentation substantially altered the metabolite profiles of samples, which are predicted to alleviate colitis via regulating inflammatory response and response to lipopolysaccharide by using network pharmacology analysis. In vivo, oral gavage of water extracts of E. cristatum fermented young apples (E.YAP) effectively alleviated DSS-induced colitis, restored the histopathology damage, reduced the levels of inflammatory cytokines, and promoted colonic expressions of tight junction proteins. Moreover, E.YAP ameliorated gut dysbacteriosis by increasing abundances of Lactobacillus,Blautia, Muribaculaceae, and Prevotellaceae_UCG-001 while inhibiting Turicibacter, Alistipes, and Desulfovibrio. Importantly, E.YAP increased colonic bile acids, such as CA, TCA, DCA, TUDCA, and LCA, thereby alleviating colitis via PXR/NF-κB signaling. Furthermore, a synbiotic combination with Limosilactobacillus reuteri WX-94, a probiotic strain isolated from feces of healthy individuals with anti-inflammatory properties, augmented anticolitis capacities of E.YAP. Our findings demonstrate that E.YAP could be a novel, potent, food-based anti-inflammatory prebiotic for relieving inflammatory injuries.

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Section: Discussionmentioning

confidence: 99%

“…cristatum fermentation increased polyphenols, flavonoids, and polysaccharides compared to the raw pomace. A recent study by Yin et al has demonstrated that fermentation with E. cristatum significantly increases the levels of polyphenols and flavonoids in Siraitia grosvenorii pomace.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Eurotium cristatum Fermented Thinned Young Apple and Mechanisms Underlying Its Alleviating Impacts on Experimental Colitis

Song,

Zhou,

Liu

et al. 2024

J. Agric. Food Chem.

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“…In 2022, China’s dark tea output reached 426,300 tons, an increase of approximately 148% compared with 172,000 tons in 2012. Recently, researchers have identified the potential use of A. cristatus to improving the quality of other plant materials such as mulberry leaves ( Yang et al, 2023 ), Ginkgo biloba seeds ( Zou et al, 2022 ), turmeric ( Xiang et al, 2020 ), and Siraitia grosvenorii ( Yin et al, 2023a ). Beyond catering to the health needs of contemporary consumers, A. cristatus -fermented foods also offer opportunities for deep processing and diversified utilization of agricultural and forestry products.…”

Section: Introductionmentioning

confidence: 99%

Morphological variation and expressed sequence tags-simple sequence repeats-based genetic diversity of Aspergillus cristatus in Chinese dark tea

Hu,

Liu,

Zhou

et al. 2024

Front. Microbiol.

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IntroductionAspergillus cristatus is a homothallic fungus that is used in the natural fermentation process of Chinese Fuzhuan tea and has been linked to the production of bioactive components. However, not much is known about the variations present in the fungus. To understand the variation of the dominant microorganism, A. cristatus, within dark tea, the present study investigated the genetic and morphological diversity of 70 A. cristatus collected across six provinces of China.MethodsExpressed sequence tags-simple sequence repeats (EST-SSR) loci for A. cristatus were identified and corresponding primers were developed. Subsequently, 15 specimens were selected for PCR amplification.ResultsThe phylogenetic tree obtained revealed four distinct clusters with a genetic similarity coefficient of 0.983, corresponding to previously identified morphological groups. Five strains (A1, A11, B1, D1, and JH1805) with considerable differences in EST-SSR results were selected for further physiological variation investigation. Microstructural examinations revealed no apparent differentiation among the representative strains. However, colony morphology under a range of culture media varied substantially between strains, as did the extracellular enzymatic activity (cellulase, pectinase, protease, and polyphenol oxidase); the data indicate that there are differences in physiological metabolic capacity among A. cristatus strains.DiscussionNotably, JH1805, B1, and A11 exhibited higher enzymatic activity, indicating their potential application in the production of genetically improved strains. The findings provide valuable insights into species identification, genetic diversity determination, and marker-assisted breeding strategies for A. cristatus.

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Black goji berry anthocyanins extend lifespan and enhance the antioxidant defenses in Caenorhabditis elegans via the JNK‐1 and DAF‐16/FOXO pathways

Xu,

Zheng,

et al. 2024

J Sci Food Agric

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BACKGROUNDThe black goji berry (Lycium ruthenicum Murr.) is known for its abundance of high‐quality natural antioxidants, particularly anthocyanins. Black goji berry anthocyanins (BGA) are receiving increasing attention because of their high safety and beneficial biological activities. Studies have shown that oxidative stress is a key factor affecting aging, whereas antioxidants are critical preventive and delaying strategies.RESULTSIn the present study, we investigated the potential anti‐aging effects and mechanism of BGA using the Caenorhabditis elegans model. We found that BGA prolonged the mean lifespan of nematodes and improve their healthspan, including locomotion, pharyngeal pumping rate and stress resistance. Subsequently, we observed a significant decrease in reactive oxygen species and malondialdehyde levels in nematodes after administering BGA. Moreover, BGA enhanced the activities of the antioxidant enzymes superoxide dismutase and catalase, and elevated the glutathione disulfide/glutathione ratio. We confirmed that BGA exerted excellent antioxidative stress activity in nematodes, which may contribute substantially to its anti‐aging effects. The health benefits of BGA in C. elegans might be closely related to petunidin‐3‐O‐glucoside, the most abundant anthocyanin in BGA. Further mechanistic investigation revealed that the JNK‐1 and DAF‐16/FOXO pathways, rather than the calorie restriction pathway, were responsible for the antioxidant stress and life‐prolonging effects of BGA in nematodes.CONCLUSIONOur research provides a theoretical foundation for studying the anti‐aging effect of BGA and a basis for developing black goji berry and its anthocyanins as functional foods with anti‐aging and antioxidative stress benefits. © 2024 Society of Chemical Industry.

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Metabolite profiling, antioxidant and anti-aging activities of Siraitia grosvenorii pomace processed by solid-state fermentation with Eurotium cristatum

Cited by 7 publications

References 57 publications

Characterization of Eurotium cristatum Fermented Thinned Young Apple and Mechanisms Underlying Its Alleviating Impacts on Experimental Colitis

Characterization of Eurotium cristatum Fermented Thinned Young Apple and Mechanisms Underlying Its Alleviating Impacts on Experimental Colitis

Morphological variation and expressed sequence tags-simple sequence repeats-based genetic diversity of Aspergillus cristatus in Chinese dark tea

Black goji berry anthocyanins extend lifespan and enhance the antioxidant defenses in Caenorhabditis elegans via the JNK‐1 and DAF‐16/FOXO pathways

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