Metabolite Profiling, Antioxidant and Key Enzymes Linked to Hyperglycemia Inhibitory Activities of Satureja hispidula: An Underexplored Species from Algeria

Abstract

In the present study, two extracts from the aerial parts of the endemic species Satureja hispidula were analyzed for the first time by ultra-high-performance liquid chromatography coupled with a diode array detector and an electrospray mass spectrometer (UHPLC-DAD-ESI/MS) method in order to identify and quantify their phenolic compounds. These extracts’ antioxidant, α-glucosidase and α-amylase inhibitory activities were also evaluated. UHPLC-DAD-ESI/MS allowed the identification of 28 and 20 compounds in the ethanolic and aqueous extracts, respectively; among them, 5-O-caffeoylquinic acid was the most abundant in both extracts. The biological assay results indicate that the species S. hispidula, besides its high antioxidant power, is also potentially useful for inhibiting the α-glucosidase enzyme. In both antioxidant and α-glucosidase inhibitory assays, the aqueous extract exhibited the most promising results, significantly better than the standards used as positive controls.

Protaetia brevitarsis larvae extract ameliorated obesity in high fat diet-fed mice by modulating gut microbiota and lipid metabolism

“…On the other hand, P. brevitarsis extract was rich in natural amino acids, polyphenols, nitrogen compounds, and organic acids, such as L-carnitine, trans-ferulic acid, creatinine, etc., which had been proven in relevant studies to exhibit good ant-obesity and regulatory effects on oxidative stress in the body [39][40][41]. Meanwhile, compared with synthetic compounds, natural bioactive compounds might be a better choice for therapeutic efficacy, and composite components of bioactives might have better therapeutic effects than single components [42,43]. In conclusion, as rich in a variety of natural bioactive components, the P. brevitarsis extract could effectively regulate the levels of inflammatory factors and oxidative stress to inhibit the occurrence of obesity.…”

A Comparative Analysis between the Phenolic Content, Key Enzyme Inhibitory Potential, and Cytotoxic Activity of Arum italicum Miller in Two Different Organs

“…Besides apigenin derivatives, from which the apigenin 6-C-glucoside-7-O-glucoside (2) is the most abundant of all the quantified compounds and corresponds to 11.38 ± 1.63 µg/mg of the A. italicum leaf extract, kaempferol 3-O-glucoside (11), myricetin (13), chryseriol (14), and trimethyl myricetin (15) were also found. This group of compounds is essential because several pharmacological effects, including antiviral, antimicrobial, anticancer, anti-inflammatory, antidiabetic, antioxidant, and cardioprotective abilities, have been attributed to them [30].…”

“…Although this previous report describes the anticancer properties of A. italicum [12], this still needs to be explored, and further studies are required. In addition, some species growing in Algeria showed interesting activity in inhibiting enzymes linked to hyperglycemia [13,14].…”