Metabolite Profiling of <i>Justicia gendarussa</i> Herbal Drug Preparations

Ratih, Gusti Ayu Made; Imawati, Maria Fatmadewi; Purwanti, Diah Intan; Nugroho, Rendra Rizki; Wongso, Suwidji; Prajogo, Bambang; Indrayanto, Gunawan

doi:10.1177/1934578x19856252

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…100–1,000 Da) can be performed using software supplied with the LC-HRMS instrument. Data can be grouped automatically into buckets with R t -m/z pairs ( x minutes- a Da) with a mass tolerance of b Da ( Ratih et al, 2019 ). Detailed methods for processing and bucketing the raw LC-MS data have been discussed in a previous publication (Thiele et al).…”

Section: Applications Of Fingerprinting Methodsmentioning

confidence: 99%

Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines

2022

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Herbal drugs or herbal medicines (HMs) have a long-standing history as natural remedies for preventing and curing diseases. HMs have garnered greater interest during the past decades due to their broad, synergistic actions on the physiological systems and relatively lower incidence of adverse events, compared to synthetic drugs. However, assuring reproducible quality, efficacy, and safety from herbal drugs remains a challenging task. HMs typically consist of many constituents whose presence and quantity may vary among different sources of materials. Fingerprint analysis has emerged as a very useful technique to assess the quality of herbal drug materials and formulations for establishing standardized herbal products. Rather than using a single or two marker(s), fingerprinting techniques take great consideration of the complexity of herbal drugs by evaluating the whole chemical profile and extracting a common pattern to be set as a criterion for assessing the individual material or formulation. In this review, we described and assessed various fingerprinting techniques reported to date, which are applicable to the standardization and quality control of HMs. We also evaluated the application of multivariate data analysis or chemometrics in assisting the analysis of the complex datasets from the determination of HMs. To ensure that these methods yield reliable results, we reviewed the validation status of the methods and provided perspectives on those. Finally, we concluded by highlighting major accomplishments and presenting a gap analysis between the existing techniques and what is needed to continue moving forward.

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Section: Applications Of Fingerprinting Methodsmentioning

confidence: 99%

Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines

2022

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Productivity of Phenolic, Flavonoid, and Antioxidant in Justicia gendarussa Burm. f. by Different Shade and Dose of Nitrogen Fertilizer

Maulana,

Batubara,

Nurcholis

2024

YYU J AGR SCI

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Justicia gendarussa Burm.f., known as gendarussa, has been used as a traditional medicine to treat thrush, headaches, bronchitis, arthritis, jaundice, otalgia, indigestion, fever, cancer, male contraception, and UV protection. J. gendarussa can grow wild as a shrub, especially in forest areas and river embankments, which can make the production of secondary metabolites inconsistent, especially phenolics group, and change the biological activity. Therefore, the purpose of this study is to determine the optimal combination of shade and nitrogen fertilizer dose for maximizing phenolic, flavonoid, and antioxidant productivity in the aerial parts of J. gendarussa. This study employed a split-plot design, with shade (0, 25, and 50%) serving as the main plot and nitrogen fertilizer doses (0, 90, 180, and 270 kg ha-1) serving as subplots. The highest productivities of phenolics, flavonoids, antioxidants, and dry weight were observed in the treatment with a nitrogen fertilizer dose of 270 kg ha-1 and no shading treatment. The dry weight of the plant's harvested aerial parts was 10.9 g plant-1. The productivity of phenolics was 210 mg GAE plant-1, while the productivity of flavonoids was 112 mg QE plant-1. Using DPPH, ABTS, FRAP, and CUPRAC methods, antioxidant productivity was determined to be 63.5; 334; 171; and 525 mol TE plant-1, respectively. Pearson correlation indicates that phenolic and flavonoid productivity is highly correlated with antioxidant productivity. Considering the research parameters of shading and nitrogen fertilizer dosage, 270 kg ha-1 nitrogen fertilizer application without shading was the optimum cultivation practice combination.

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Metabolite Profiling of Justicia gendarussa Herbal Drug Preparations

Cited by 2 publications

References 4 publications

Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines

Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines

Productivity of Phenolic, Flavonoid, and Antioxidant in Justicia gendarussa Burm. f. by Different Shade and Dose of Nitrogen Fertilizer

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