Metabolite profiling of polyphenols in Vaccinium berries and determination of their chemopreventive properties

Prencipe, Francesco Pio; Bruni, Renato; Guerrini, Alessandra; Rossi, Damiano; Benvenuti, Stefania; Pellati, Federica

doi:10.1016/j.jpba.2013.11.016

Cited by 60 publications

(69 citation statements)

References 41 publications

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“…As example, Santos et al (2013) using hydro-alcoholic mixtures found 6.41 mg/g dw, meanwhile Vieira et al (2017) achieved a maximum of 10.7 mg/g dw. In other natural sources such as in Vaccinium floribundum Kunth berries were found 0.015 mg/g dw (Prencipe et al, 2014), 0.76 and 0.89 mg/g dw in Lonicera japonica Thunb. flowers and 17.2 mg/ g dw on Solanum betaceum skin extract (Orqueda et al, 2017).…”

Section: Comparison With Other Responses Reported Using Non-desmentioning

confidence: 93%

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Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

Vieira

Prieto

Barros

et al. 2018

Industrial Crops and Products

115

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A B S T R A C TThe extraction of phenolic compounds from walnut leaves (Juglans regia L.) was optimized using heat-assisted extraction and deep eutectic solvents based on choline chloride and carboxylic acids. A preliminary solvent screening was performed using a selected group of carboxylic acids as hydrogen bond donors, showing that the highest extraction yield of phenolic compounds was obtained using choline chloride mixtures with butyric or phenylpropionic acid at a mole ratio 1:2, with 20% of water (w/w). The extraction conditions (time, temperature and water proportion) were then optimized by an experimental design, assisted by response surface methodology. To evaluate the response, the three most abundant compounds identified by HPLC (neochlorogenic acid, quercetin 3-O-glucoside and quercetin O-pentoside) were quantified. Additionally, the solid/liquid ratio effect at the optimal conditions, in dose-response format, was studied in view of its upscale, not showing any significant decrease until 140 g/L. The results here presented provide valuable information towards the design of a process in a pre-industrial form for the extraction of phenolic compounds from J. regia leaves using deep eutectic solvents.

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Section: Comparison With Other Responses Reported Using Non-desmentioning

confidence: 93%

“…Lower amounts were recovered from other material sources such as 0.0133 mg/g dw on Rosa canina hips (Cunja et al, 2015) and 0.101 mg/g fw in V. floribundum berries (Prencipe et al, 2014).…”

Section: Comparison With Other Responses Reported Using Non-desmentioning

confidence: 94%

Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

Vieira

Prieto

Barros

et al. 2018

Industrial Crops and Products

115

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“…Fifteen anthocyanins were assessed through their major fragment ions at m/z 303, 287, 317, 301, and 331, which are characteristic of the aglycones delphinidin, cyanidin, petunidin, peonidin, and malvidin, respectively (Table 5, Supplementary material). Delphinidin-3-O-galactoside and delphinidin-3-O-glucoside are predominant anthocyanins in fruit extracts (Može et al, 2011;Prencipe, Bruni, Guerrini, Benvenuti, & Pellati, 2014).…”

Section: Anthocyaninsmentioning

confidence: 99%

Seasonal variations of the phenolic constituents in bilberry ( Vaccinium myrtillus L.) leaves, stems and fruits, and their antioxidant activity

et al. 2016

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The seasonal variations of the content and diversity of phenolic compounds, as well as the antioxidant activity of leaves, stems and fruits of bilberry collected in May, July and September, were evaluated for two consecutive years. UPLC/MS(n) analyses showed the predominance of anthocyanins in fruits, caffeic acid derivatives in leaves whereas flavanol oligomers represented more than half of the phenolic compounds in stems. Thioacidolysis revealed degrees of polymerization between 2 and 4 and (-)-epicatechin as the main flavanol unit. The sum of the phenolic compounds by UPLC was highly correlated with the total polyphenol content and the antioxidant activity in the DPPH test for all the extracts except for May leaves. The latter were relatively rich in p-coumaric acid derivatives. Seasonal effects were more marked for leaves, which exhibited higher antioxidant activities and phenolic contents in July and September when these parameters were at their highest in July for stems.

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“…It has been reported that anthocyanin galactosides elute before their equivalent glucosides in reversed-phase columns (Santos-Buelga, García-Viguera, & Tomás-Barberán, 2003). Further comparison with extracts obtained from Coriaria myrtifolia fruits and V. myrtillus berries, which are known to contain both the 3-Ogalactosides and 3-O-glucosides (as well as 3-O-arabinosides in the case of V. myrtillus) of delphinidin, cyanidin, petunidin, peonidin and malvidin (Baj, Bombardelli, Gabetta, & Martinelli, 1983;Escribano-Bailón, Santos-Buelga, Alonso, & Salinas, 2002;Latti, Riihinen, & Kainulainen, 2008;Prencipe et al, 2014), allowed assigning the peaks 1, 3, 6, 8 and 10 as the respective 3-O-galactosides of the indicated anthocyanidins.…”

Section: Analysis Of Phenolic Compounds By Hplc-dad-msmentioning

confidence: 99%

Anthocyanin and phenolic characterization, chemical composition and antioxidant activity of chagalapoli (Ardisia compressa K.) fruit: A tropical source of natural pigments

Joaquín-Cruz

Dueñas

García‐Cruz

et al. 2015

Food Research International

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Metabolite profiling of polyphenols in Vaccinium berries and determination of their chemopreventive properties

Cited by 60 publications

References 41 publications

Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

Seasonal variations of the phenolic constituents in bilberry ( Vaccinium myrtillus L.) leaves, stems and fruits, and their antioxidant activity

Anthocyanin and phenolic characterization, chemical composition and antioxidant activity of chagalapoli (Ardisia compressa K.) fruit: A tropical source of natural pigments

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