Metabolite profiling using liquid chromatography/quadrupole time‐of‐flight mass spectrometry for the identification of a suitable marker and target matrix of griseofulvin use in bovines

Tarbin, J. A.; Fussell, Richard J.

doi:10.1002/rcm.6574

Cited by 1 publication

(2 citation statements)

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“…The extraction method was based on the acetonitrile water extraction method described elsewhere . Briefly, cryogenically milled analytical portions (5 g) of the samples were spiked with 12 available deuterated/ 13 C-labeled analogues.…”

Section: Methodsmentioning

confidence: 99%

“…The extraction method was based on the acetonitrile water extraction method described elsewhere. 20 Briefly, cryogenically milled analytical portions (5 g) of the samples were spiked with 12 available deuterated/ 13 C-labeled analogues. Water (2−5 mL depending on the sample) was added and the extraction performed using 1% oxalic acid in acetonitrile (15 mL).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Investigation into the Occurrence in Food of Veterinary Medicines, Pharmaceuticals, and Chemicals Used in Personal Care Products

Fussell

López

Mortimer

et al. 2014

J. Agric. Food Chem.

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Human exposure to emerging contaminants by indirect routes is of increasing interest. This study assessed the contamination of food by chemicals used in human pharmaceuticals (HPs), veterinary medicines (VMs), and personal care products (PCPs). A prioritization study was undertaken to identify the chemicals and food-producing scenarios most likely to result in contamination of food. Around 400 samples of mushrooms, vegetables, aquaculture products, and animal tissues were collected from sites in the United Kingdom, along with aquaculture products imported from Southeast Asia. A number of multianalyte methods were developed and validated for the analysis of the prioritized compounds in these samples. The analysis of all sample-method combinations required approximately 18000 determinations. Around 325 individual residues, including parabens, musk compounds, and antibiotics, were detected in 118 individual samples, but mostly at low nanograms per gram concentrations. Results suggest that the limited contamination of target chemicals occurred in the realistic food-producing scenarios investigated.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Investigation into the Occurrence in Food of Veterinary Medicines, Pharmaceuticals, and Chemicals Used in Personal Care Products

Fussell

López

Mortimer

et al. 2014

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Metabolite profiling using liquid chromatography/quadrupole time‐of‐flight mass spectrometry for the identification of a suitable marker and target matrix of griseofulvin use in bovines

Abstract: 4-Demethyl- and 6-demethylgriseofulvin have been identified as potential marker compounds of griseofulvin use in cattle. Liver was identified as the target matrix. Hair was shown to have potential for non-invasive testing.

Cited by 1 publication

References 5 publications

Investigation into the Occurrence in Food of Veterinary Medicines, Pharmaceuticals, and Chemicals Used in Personal Care Products

Investigation into the Occurrence in Food of Veterinary Medicines, Pharmaceuticals, and Chemicals Used in Personal Care Products

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