Metabolites from nematophagous fungi and nematicidal natural products from fungi as alternatives for biological control. Part II: metabolites from nematophagous basidiomycetes and non-nematophagous fungi

Degenkolb, Thomas; Vilcinskas, Andreas

doi:10.1007/s00253-015-7234-5

Cited by 84 publications

(33 citation statements)

References 72 publications

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“…There are few investments in the discovery of new drugs for the treatment of parasites. Considering that there are works in the literature relating nemathophagous fungi extracts with nematicidal activity and commercial products using nemathophagous fungi [7,18,19], we performed extraction of the P. chlamydosporia metabolites with an organic solvent; the extract was fractionated with solvents of different polarity scale and evaluated the compounds for nematicidal capacity. We observed that EtOAc was able to paralyze 84% of the C. elegans larvae at a concentration of 1,000 μg/mL, whereas CH 2 Cl 2…”

Section: Discussionmentioning

confidence: 99%

“…The administration of nematophagous fungi is considered a promising alternative in the prophylaxis of parasitic gastrointestinal helminthiasis [5]. Willcox and Tribe [6] reported the association between the fungus Pochonia chlamydosporia and the nematode Heterodera schachtii, as the primary and secondary metabolites of nematophagous fungi have been known to be involved in this interaction [5,7,8]. In the review presented by Li et al [9], 179 substances from fungi, including nematophagous, were reported as potential nematicidal drugs; therefore, these fungi can be considered an important source of new drugs.…”

Section: Introductionmentioning

confidence: 99%

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Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic?

Ferreira

Machado

Furtado

et al. 2020

Preprint

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Background: Infection by nematodes is a problem for human health, livestock, and agriculture, as it causes deficits in host health, increases production costs, and incurs less food supply. The control of these parasites is usually done using anthelmintics, which, in most cases, have not been fully effective. Therefore, the search for new molecules with anthelmintic potential is necessary. Methods: In the present study, we isolated and characterized molecules from the nematophagous fungus Pochonia chlamydosporia and tested these compounds on three nematodes: Caenorhabditis elegans, Ancylostoma ceylanicum, and Ascaris suum. Results: The ethyl acetate extract showed nematicidal activity on the nematode model C. elegans. We identified the major substance present in two subfractions of this extract as ketamine. Then, we tested this compound on C. elegans and the parasites A. ceylanicum and A. suum using hamsters and mice as hosts, respectively. We did not find a difference between the animal groups when considering the number of worms recovered from the intestines of animals treated with ketamine (6 mg) and albendazole (P > 0.05). The parasite burden of larvae recovered from the lungs of mice treated with ketamine was similar to those treated with ivermectin. Conclusion: These results presented here demonstrated the nematicidal activity of ketamine in vitro and in vivo. Thus, confirming the nematicidal potential of the molecule present in the fungus P. chlamydosporia may consist of a new method of controlling parasites.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic?

Ferreira

Machado

Furtado

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…In addition, in cattle, efficacy was impaired when high FEC coincided with dung pat degradation due to rainfall (Dimander, Höglund, Uggla, Spörndly, & Waller, ). Metabolites and other natural products from fungi may also serve as biological control agents, and, for example, substances of the oligosporon type have shown some in vitro activity against H. contortus (Degenkolb & Vilcinskas, ). However, several of these compounds are unstable in pure form, and at present, they have not been explored for use in livestock.…”

Section: Main Means Of Detection Prevention and Controlmentioning

confidence: 99%

Mind the gaps in research on the control of gastrointestinal nematodes of farmed ruminants and pigs

Charlier

Thamsborg

Bartley

et al. 2017

Transbound Emerg Dis

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Gastrointestinal (GI) nematode control has an important role to play in increasing livestock production from a limited natural resource base and to improve animal health and welfare. In this synthetic review, we identify key research priorities for GI nematode control in farmed ruminants and pigs, to support the development of roadmaps and strategic research agendas by governments, industry and policymakers. These priorities were derived from the DISCONTOOLS gap analysis for nematodes and follow-up discussions within the recently formed Livestock Helminth Research Alliance (LiHRA). In the face of ongoing spread of anthelmintic resistance (AR), we are increasingly faced with a failure of existing control methods against GI nematodes. Effective vaccines against GI nematodes are generally not available, and anthelmintic treatment will therefore remain a cornerstone for their effective control. At the same time, consumers and producers are increasingly concerned with environmental issues associated with chemical parasite control. To address current challenges in GI nematode control, it is crucial to deepen our insights into diverse aspects of epidemiology, AR, host immune mechanisms and the socio-psychological aspects of nematode control. This will enhance the development, and subsequent uptake, of the new diagnostics, vaccines, pharma-/nutraceuticals, control methods and decision support tools required to respond to the spread of AR and the shifting epidemiology of GI nematodes in response to climatic, land-use and farm husbandry changes. More emphasis needs to be placed on the upfront evaluation of the economic value of these innovations as well as the socio-psychological aspects to prioritize research and facilitate uptake of innovations in practice. Finally, targeted regulatory guidance is needed to create an innovation-supportive environment for industries and to accelerate the access to market of new control tools.

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“…Some of these include: the antimalarial properties of Cordyceps species 2 and Bulgaria inquinans, 3 and the amoebicidal 4 and anti-trypanosomiasis 5 properties of Pleurotus ostreatus. Other reported biological activities include nematicidal, 6 anti-inflammatory and immunomodulatory, 7 and anticancer 8,9 properties among others. As a follow up to earlier reports on the scientific validation of the health benefits and the characterization of bioactive secondary metabolites from indigenous edible mushrooms in Nigeria, [10][11][12][13] the present study aimed to determine the nutraceutical potentials of the n-hexane extract (NHE) of the fruiting bodies of the edible mushroom P. ostreatus in the management of malaria infections.…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial Activity of the n-Hexane Extract from <i>Pleurotus ostreatus</i> (Jacq. ex. Fr) P. Kumm.

Afieroho¹,

Siwe‐Noundou²,

Onyia³

et al. 2019

tjps

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Amaç: Bu tasarım çalışması "International Conference on Harmonization" rehberleri kapsamındaki tasarımda kalite yaklaşımı çerçevesinde uygulanmıştır. Yapay sinir ağları (ANN) kullanılarak ketiapin fumaratın değiştirilmiş salımlı tablet formülasyonunun kalitesi değerlendirilmiş ve referans ürüne benzer olan yeni bir formülasyon tespit edilmiştir. Gereç ve Yöntemler: On iki farklı formül üretilmiş ve test edilmiştir. Referans ürünün analiz sonuçları ve deneysel sonuçlarımız çıktı olarak Intelligensys Ltd. şirketine ait programlarında ANN'nin eğitimi için kullanılmıştır. Bulgular: INForm V.4 ANN programı tarafından önerilen yeni bir formülasyon (F13) ile gastrointestinal sistemdeki üç farklı pH da çözünme testleri yapılmıştır. Bu formülasyonun uygunluğu da f2 benzerlik testi sonuçları karşılaştırılarak doğrulanmıştır. Sonuç: Bu programların kullanılması, çoklu değerlendirme yöntemleri ve daha düşük maliyetle Ar-Ge süreçlerini desteklemekte ve alternatif formülasyonlar daha hızlı tespit edilebilmektedir. Anahtar kelimeler: Ketiapin fumarat, tasarımda kalite, yapay sinir ağları, bulanık mantık, uzatılmış salım tabletler, yaş granülasyon Objectives: This design study was implemented within the scope of the quality by design approach, which included the "International Conference on Harmonization" guidelines. We evaluated the quality of a modified-release tablet formulation of quetiapine fumarate, which was designed using artificial neural networks (ANN), and determined a new formulation that was similar to the reference product. Materials and Methods: Twelve different formulations were produced and tested. The reference product's results and our experimental results were used as outputs for the training of the ANN programs of Intelligensys Ltd. Results: Dissolution tests were performed with the new formulation (F13) suggested by the INForm V.4 ANN program in three different pHs of the gastrointestinal system. The compliance of this formulation was confirmed by comparing the results with an f2 similarity test. Conclusion: Use of these programs supports research and development processes with multiple evaluation methods and alternative formulations may be determined faster and at lower cost.

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Metabolites from nematophagous fungi and nematicidal natural products from fungi as alternatives for biological control. Part II: metabolites from nematophagous basidiomycetes and non-nematophagous fungi

Cited by 84 publications

References 72 publications

Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic?

Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic?

Mind the gaps in research on the control of gastrointestinal nematodes of farmed ruminants and pigs

Antiplasmodial Activity of the n-Hexane Extract from <i>Pleurotus ostreatus</i> (Jacq. ex. Fr) P. Kumm.

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