Metabolites from specific intestinal bacteria in vivo fermenting Lycium barbarum polysaccharide improve collagenous arthritis in rats

Liu, Yanghanxiu; Liu, Liu; Luo, Jing; Peng, Xichun

doi:10.1016/j.ijbiomac.2022.11.257

Cited by 14 publications

(3 citation statements)

References 52 publications

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“…Lachnospiraceae related metabolic pathways are known to affect homeostasis implying proinflammatory cytokines ( Vacca et al, 2020 ). Our results are partly consistent with the research across the globe, precisely with the results of recent ( Liu et al, 2023 ) animal model study, which demonstrated the increase of Lachnospiraceae , and Shi et al (2019) also demonstrated the relation of this taxon to atherosclerosis in RA. Abundance of Dorea was previously associated with the most autoimmune disorders such as Hashimoto disease ( Zhao et al, 2018 ), type 1 diabetes mellitus ( Liu et al, 2021 ) and multiple sclerosis ( Bonnechère, Amin & van Duijn, 2022 ).…”

Section: Discussionsupporting

confidence: 93%

Gut microbiome-immune interactions and their role in rheumatoid arthritis development

Nurgaziyev,

Issilbayeva,

Bersimbaev

et al. 2024

PeerJ

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Objective The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on the development of rheumatoid arthritis. Methods This study was performed in Astana, Kazakhstan, and included 77 Kazakh female patients older than 18 years, who met the American College of Rheumatology 2010 classification criteria for rheumatoid arthritis (RA), and 113 healthy controls. The DNA was extracted from fecal samples obtained from all study participants for subsequent sequencing at the 16S rRNA gene V1-V3 locus, facilitating the analysis of the gut microbiome. The Multiplex immunoassay was employed to measure the concentrations of inflammatory cytokines, chemokines, and immunoglobulins in both fecal and plasma samples. Results Our taxonomic analysis revealed significant differences in the composition of the gut microbiota between the healthy control cohort and the cohort with rheumatoid arthritis RA. Alpha diversity was significantly lower in the RA group. Lachnospiraceae were the most abundant taxon and found to be crucial, showing correlations with immunological markers such as IL5. Additionally, Lachnospiraceae and Oscillospiraceae exhibited the most predictable power and distinguished the composition of both study groups. Conclusion Our study identifies key differences in the gut microbiome of RA patients, revealing distinct microbial patterns and specific taxa abundance. We highlight potential biomarkers in immunological and bacterial pathways, offering insights into RA development and indicating possibilities for personalized treatment.

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Section: Discussionsupporting

confidence: 93%

Gut microbiome-immune interactions and their role in rheumatoid arthritis development

Nurgaziyev,

Issilbayeva,

Bersimbaev

et al. 2024

PeerJ

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“…Recent studies have shown that the intestinal ora produces some metabolites with weight loss effects in the process of fermenting polysaccharides [51,52]. Li et al found that Clostridium leptum can alleviate obesity by fermenting metabolites produced by FP [53]. Obesity is considered one of the risk factors for ESCA [54,55].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota, human blood metabolites and esophageal cancer: a Mendelian randomization study

LI,

Xu,

Yang

et al. 2024

Preprint

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Background: Unbalances in the gut microbiota have been proposed as a possible cause of esophageal cancer, yet the exact causal relationship remains unclear. Objectives: To investigate the potential causal relationship between the gut microbiota and esophageal cancer with Mendelian randomization (MR) analysis. Methods: Genome-wide association studies (GWAS) of 207 gut microbial taxa (5 phyla, 10 classes, 13 orders, 26 families, 48 genera, and 105 species) and 205 gut microbiota metabolic pathways conducted by the Dutch Microbiome Project (DMP) and a FinnGen cohort GWASs of esophageal specified the summary statistics. To investigate the possibility of a mediation effect between the gut microbiota and esophageal cancer, mediation MR analyses were performed for 1,091 blood metabolites and 309 metabolite ratios. Results: MR analysis indicated that the relative abundance of 10 gut microbial taxa was associated with esophageal cancer but all the 12 gut microbiota metabolic pathways with esophageal cancer indicated no statistically significant association existing. Two blood metabolites and a metabolite ratio were discovered to be mediating factors in the pathway from gut microbiota to esophageal cancer. Conclusion: This research indicated the potential mediating effects of blood metabolites and offered genetic evidence in favor of a causal correlation between gut microbiota and esophageal cancer.

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“…Moreover, the abundance of specific flora increased in Complete Freund’s adjuvant (CFA) rats after LBP intervention. In rats, LBP intervention inhibited the pro-inflammatory cytokines IL-1α, IL-1β, TNF-α, and IL-6, thereby alleviating RA ( 54 ). Thirdly, the amino acid disorder could be improved.…”

Section: The Mechanism Of Traditional Chinese Medicine In Preventing ...mentioning

confidence: 99%

Prevention and treatment of rheumatoid arthritis through traditional Chinese medicine: role of the gut microbiota

Liang,

Liu,

Cheng

et al. 2023

Front. Immunol.

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Recently, despite the increasing availability of treatments for Rheumatoid arthritis (RA), the incidence of RA and associated disability-adjusted life years have been on the rise globally in the late decades. At present, accumulating evidence has been advanced that RA is related to the gut microbiota, therefore, the therapeutic approaches for RA by regulating the gut microbiota are anticipated to become a new means of treatment. Traditional Chinese medicine (TCM) can regulate immunity, reduce inflammation and improve quality of life in various ways. Moreover, it can treat diseases by affecting the gut microbiota, which is a good way to treat RA. In this review, we mainly explore the relationship between TCM and gut microbiota regarding the perspective of treating RA. Moreover, we comprehensively summarize the roles of gut microbiota in the onset, development, progression, and prognosis of RA. Additionally, we elucidate the mechanism of TCM prevention and treatment of RA by the role of microbiota. Finally, we provide an evidence-based rationale for further investigation of microbiota-targeted intervention by TCM.

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Metabolites from specific intestinal bacteria in vivo fermenting Lycium barbarum polysaccharide improve collagenous arthritis in rats

Cited by 14 publications

References 52 publications

Gut microbiome-immune interactions and their role in rheumatoid arthritis development

Gut microbiome-immune interactions and their role in rheumatoid arthritis development

Gut microbiota, human blood metabolites and esophageal cancer: a Mendelian randomization study

Prevention and treatment of rheumatoid arthritis through traditional Chinese medicine: role of the gut microbiota

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