Metabolites isolated from urine of rats fed photodieldrin

In vitro metabolism of carbon-14 photodieldrin by microsomal mixed-function oxidase of mouse, rat, and house flies

“…Although considerable attention has been paid to the studies of the metabolism of dieldrin in various animals (Matthews and Matsumura, 1969;Matthews et al, 1971; McKinney et al, 1972; Nelson and Matsumura, 1973) only a few reports are available on the metabolism of photodieldrin (Khan et al, 1969; Klein et al, 1970;Dailey et al, 1972). Recently, Klein et al (1970) showed the in vivo formation of ketodieldrin, "Klein's metabolite," in the male rat and of four unidentified polar metabolites in the female rat urine. In vivo metabolism of photodieldrin can be inhibited by an antioxidant synergist, sesamex (Khan et al, 1970).…”

Photochemical decomposition of heptachlor epoxide

“…The strain is probably caused by the carbonyl being incorporated into two fused five-membered rings, which indicates semicage structure II. Also the general appearance of the fingerprint region of the spectrum with many narrow sharp bands is like that of other semicage chlorinated pesticides such as photodieldrin (Klein et al, 1970).…”

Novel Dechlorane Analogues and Possible Sources in Peregrine Falcon Eggs and Shark Livers from the Western North Atlantic Regions

“…Photodieldrin has been reported as a main photoinduced isomerization product of dieldrin (see their structures in Figure S8), suggesting the likelihood of photo isomerization of Dec603 in the environment. Rat exposure studies demonstrate keto-photodieldrin as one of the principal metabolites of photodieldrin in urine. − On the basis of these studies, we suggest that other than the direct metabolism of Dec603, compound I may also be produced from metabolic transformation of Dec603’s photoisomer (compound II ), followed by oxidation to form U2. Therefore, we hypothesize that U2 is a metabolic transformation product of Dec603 or its photo intermediate.…”