Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers

Wen, Weihua; Wen, Jia; Lü, Lin; Liu, Hua; Yang, Jun; Cheng, Huirong; Che, Wangjun; Li, Liang; Zhang, Guanbei

doi:10.1016/j.taap.2011.04.013

Cited by 31 publications

(27 citation statements)

References 37 publications

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“…The concentration of urinary As had a geometric mean of 9.13 µg/g creatinine (8.39 µg/L) in the exposed groups of this study. Even when the study subjects were residents living near the smelter, the levels of As in the present study were lower than those reported in other heavily contaminated areas, such as Bangladesh, 20.77 μg/L ( 9 ); China, 28.30 μg/L ( 10 ); Taiwan 20.71 μg/g creatinine ( 11 ), but higher than that of the general population in Korea, 7.10 μg/L ( 12 ). Although urinary As did not show a decrease according to the distance from the smelter using univariate analysis, which may be due to the element’s short metabolic half-life, multiple linear regression models showed that urinary As levels were significantly inversely associated with the distance from the smelter.…”

Section: Discussioncontrasting

confidence: 86%

Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea

et al. 2016

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Concentrations of heavy metals exceed safety thresholds in the soil near Janghang Copper Refinery, a smelter in Korea that operated from 1936 to 1989. This study was conducted to evaluate the level of exposure to toxic metals and the potential effect on health in people living near the smelter. The study included 572 adults living within 4 km of the smelter and compared them with 413 controls group of people living similar lifestyles in a rural area approximately 15 km from the smelter. Urinary arsenic (As) level did not decrease according to the distance from the smelter, regardless of gender and working history in smelters and mines. However, in subjects who had no occupational exposure to toxic metals, blood lead (Pb) and cadmium (Cd) and urinary Cd decreased according to the distance from the smelter, both in men and women. Additionally, the distance from the smelter was a determinant factor for a decrease of As, Pb, and Cd in multiple regression models, respectively. On the other hands, urinary Cd was a risk factor for renal tubular dysfunction in populations living near the smelter. These results suggest that Janghang copper smelter was a main contamination source of As, Pb, and Cd, and populations living near the smelter suffered some adverse health effects as a consequence. The local population should be advised to make efforts to reduce exposure to environmental contaminants, in order to minimize potential health effects, and to pay close attention to any health problems possibly related to toxic metal exposure.

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Section: Discussioncontrasting

confidence: 86%

Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea

et al. 2016

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“…The geometric mean concentration of As in urine was determined at 7.10 μg/L (male 7.63 μg/L, female 6.75 μg/ L) in Korean adults. The urine As level observed in Korean adults was lower than those reported in other Asian countries [Bangladesh, 20.77 μg/L (16) ; China, 28.30 μg/L (17) ; Taiwan 20.71 μg/g creatinine (18) ], but was similar or higher than western countries [Spain, 1.14 μg/L (19) ; Italy, 7.8 μg/L (20) ]. However, urine As from this study was similar level with previous report by the same method in Korea [8.47 μg/g creatinine (21) ].…”

Section: Discussioncontrasting

confidence: 63%

Urinary Arsenic Concentrations and their Associated Factors in Korean Adults

Bae¹,

Ryu²,

Choi³

et al. 2013

Toxicological Research

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Arsenic (As) is a well-known human carcinogen and its dietary exposure has been found to be the major route of entry into general population. This study was performed to assess the body levels of As and their associated factors in Korean adults by analyzing total As in urine. Urine and blood samples were collected from 580 adults aged 20 years and older, who had not been exposed to As occupationally. Demographic information was collected with the help of a standard questionnaire, including age, smoking, alcohol intake, job profiles, and diet consumed in the last 24 hrs of the study. Total As, sum of As(III), As(V), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), in urine was determined using atomic absorption spectrometer involving hydride generation method. The geometric mean concentration of total As in urine was 7.10 μg/L. Urine As was significantly higher in men (7.63 μg/L) than in women (6.75 μg/ L). Age, smoking, alcohol consumption, and job profiles of study subjects did not significantly affect the concentration of As in urine. No significant relationship was observed between body mass index (BMI), Fe, and total cholesterol in serum and urinary As. Urine As level was positively correlated with seaweeds, fishes & shellfishes, and grain intake. A negative correlation between urinary As level and HDL-cholesterol in serum and meat intake was observed. Overall, these results suggest that urinary As concentration could be affected by seafood consumption. Therefore, people who frequently consume seafood and grain need to be monitored for chronic dietary As exposure.

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“…Another study by Eom et al [ 57 ] reported an average concentration of 8.47 μg/L using the same methods. In a high-risk area for arsenic exposure in Bangladesh, the total urine arsenic concentration was 20.77 μg/L on average [ 58 ], which is lower than that in China (28.30 μg/L) [ 59 ] and Taiwan (20.71 μg/L) [ 60 ], but higher than that in Spain (1.14 μg/L). However, these findings cannot be generalized to the South Korean population; thus, further studies regarding arsenic exposure level using representative data in South Korea are needed.…”

Section: Level Of Human Exposure To Arsenicmentioning

confidence: 99%

Health Effects of Chronic Arsenic Exposure

Hong

Song

Chung

2014

J Prev Med Public Health

386

146

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Arsenic is a unique element with distinct physical characteristics and toxicity whose importance in public health is well recognized. The toxicity of arsenic varies across its different forms. While the carcinogenicity of arsenic has been confirmed, the mechanisms behind the diseases occurring after acute or chronic exposure to arsenic are not well understood. Inorganic arsenic has been confirmed as a human carcinogen that can induce skin, lung, and bladder cancer. There are also reports of its significant association to liver, prostate, and bladder cancer. Recent studies have also suggested a relationship with diabetes, neurological effects, cardiac disorders, and reproductive organs, but further studies are required to confirm these associations. The majority of research to date has examined cancer incidence after a high exposure to high concentrations of arsenic. However, numerous studies have reported various health effects caused by chronic exposure to low concentrations of arsenic. An assessment of the health effects to arsenic exposure has never been performed in the South Korean population; thus, objective estimates of exposure levels are needed. Data should be collected on the biological exposure level for the total arsenic concentration, and individual arsenic concentration by species. In South Korea, we believe that biological exposure assessment should be the first step, followed by regular health effect assessments.

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Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers

Cited by 31 publications

References 37 publications

Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea

Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea

Urinary Arsenic Concentrations and their Associated Factors in Korean Adults

Health Effects of Chronic Arsenic Exposure

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