Metabolites of Eurotium Species, Their Antioxidative Properties and Synergism with Tocopherol

Ishikawa, Yukihiro; Morimoto, Kyozo; Hamasaki, Takashi

doi:10.1111/j.1365-2621.1985.tb10579.x

Cited by 16 publications

(13 citation statements)

References 11 publications

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“…FG and its related compounds were found to be synergistic agents of the -tocopherol antioxidant in an assay of lipid peroxidation, using the active oxygen method (AOM) and a substrate of lard. 24) However, the isolated antioxidants were shown not to have a synergistic effect, but rather an additive effect in the assay of present study (data not shown). We think that the isolated antioxidants may act in cooperation with -tocopherol, which is contained in arabushi, to inhibit lipid oxidation during the manufacture of karebushi, although the relationship between the antioxidative activity of the isolated antioxidants and -tocopherol in karebushi needs further research.…”

Section: Activity Of the Antioxidants Isolated From Filamentous Fungicontrasting

confidence: 46%

“…These compounds have also been isolated from extracts of fungi of E. chevalieri IFO4086 and E. repens IFO4041 which were not isolated from katsuobushi. 24) In the present study, they were found to be produced by Eurotium species which were isolated from katsuobushi such as E. chevalieri JCM23047, E. chevalieri NBRC4090, E. repens JCM23060, and E. repens KBN2062. For the first time, antioxidants were found to be abundantly produced from E. herbariorum NE-1 and NE-4 which have long been used to manufacture karebushi, a kind of katsuobushi.…”

Section: Identification Of the Antioxidants Produced By Filamentous Fmentioning

confidence: 52%

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Antioxidants Produced byEurotium herbariorumof Filamentous Fungi Used for the Manufacture of Karebushi, Dried Bonito (Katsuobushi)

Miyake

Ito

Itoigawa

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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Extracts prepared by culturing ten filamentous fungi from Aspergillus and Eurotium species isolated from dried bonito (katsuobushi) were examined for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity. The extracts prepared by culturing E. herbariorum NE-1 and NE-4, which are used in the molding process for the manufacture of karebushi (a kind of katsuobushi), were shown to have higher activity than the others. Five antioxidants were isolated from the extracts and identified as isodihydroauroglaucin (IDAG), auroglaucin (AG), dihydroauroglaucin (DAG), tetrahydroauroglaucin (TAG), and flavoglaucin (FG) by 1 H-NMR, 13 C-NMR, and EI-MS analyses. Compared with -tocopherol, the isolated antioxidants exhibited high antioxidative activity for the radical scavenging capacity of DPPH and superoxide, but low activity for inhibiting the autoxidation of docosahexaenoic acid (DHA). The isolated antioxidants were produced by the Eurotium species, but not by the Aspergillus species. DAG and TAG exhibited higher radical scavenging capacity than the other antioxidants and were abundantly contained in the extracts of E. herbariorum NE-1 and NE-4.

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Section: Activity Of the Antioxidants Isolated From Filamentous Fungicontrasting

confidence: 46%

Section: Identification Of the Antioxidants Produced By Filamentous Fmentioning

confidence: 52%

Antioxidants Produced byEurotium herbariorumof Filamentous Fungi Used for the Manufacture of Karebushi, Dried Bonito (Katsuobushi)

Miyake

Ito

Itoigawa

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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“…Aoyama et al (6) isolated the antioxidative phenolic compounds--citrinin, protocatechuic acid and curvulic acid--from fungi. We also have reported that some microbial metabolites are potent antioxidants and Toc synergists in several fat substrates with excellent activity compared to that of Toc alone (9)(10)(11)(12)(13)(14). We also have reported that some microbial metabolites are potent antioxidants and Toc synergists in several fat substrates with excellent activity compared to that of Toc alone (9)(10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

Atrovenetin as a potent antioxidant compound from penicillium species

Ishikawa

Morimoto²,

Iseki

1991

J Americ Oil Chem Soc

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We have established a program to screen large numbers of wild-type fungi isolated from soil for potential producers of antioxidants and synergists for tocopherol (Toc). An antioxidant and potent Toc synergist was isolated from mycelial mats of Penicillium paraherquei. It was one of the deoxyherqueinone-type phenalenones and has been identified as atrovenetin.Under autoxidation conditions, the induction periods of this compound (0.025%) tested by the active oxygen method were 571 and 171 hr in lard with and without Toc (0.04%), respectively. It was also capable of stabilizing vegetable oils such as soybean, rapeseed and palm oils.

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“…Antioxidative substances produced by bacteria, yeast and fungi may serve as antioxidants, synergists, scavengers or lipoxygenase inhibitors and they are also differ in nature. Ishikawa et al (1985) reported that the metabolites (flavoglaucin derivatives) from Eurotium spp. had different antioxidant activity and suggested that the number and the position of the double bond causes instability of each derivative.…”

Section: Antioxidant Activity Production Of Rumen Protozoa and Bacteriamentioning

confidence: 99%

Effects of protozoa on the antioxidant activity in the ruminal fluid and blood plasma of cattle

Gazi¹,

Yokota²,

Tanaka³

et al. 2007

Animal Science Journal

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The objective of this study was to investigate the antioxidant status in ruminal fluid and blood plasma among three faunated and two defaunated (protozoa‐free) cattle (average bodyweight of 225 kg), fed hay plus concentrate. The extra cellular antioxidant activity of the mixed protozoa and bacteria suspensions were also studied in vitro. The antioxidant activity was detected by means of the free radical scavenging ability. The activity (units/microbial nitrogen) of the protozoal suspension increased from 59 (0 h) to 318 (18 h), and decreased to 40 (24 h) during incubation. The activity of the bacterial suspension also increased from 111 (0 h) to 644 (18 h), and decreased to 533 (24 h). The antioxidant activity (units/mL, U/mL) in the ruminal fluid of faunated (ranging from 116 to 254) and defaunated (ranging from 66 to 110) cattle was increased after 2 h and decreased after 5 h of feeding, being significantly higher in the faunated cattle. The antioxidant activity of blood plasma (U/mL) ranged from 248 to 316 in the faunated and 121–170 in the defaunated cattle during 0–5 h after feeding, being significantly higher in the faunated cattle. Therefore, defaunation possibly causes a decrease in the antioxidant level in the ruminal fluid, and may impair the health and performance of ruminants through an oxidant–antioxidant imbalance.

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Metabolites of Eurotium Species, Their Antioxidative Properties and Synergism with Tocopherol

Cited by 16 publications

References 11 publications

Antioxidants Produced byEurotium herbariorumof Filamentous Fungi Used for the Manufacture of Karebushi, Dried Bonito (Katsuobushi)

Antioxidants Produced byEurotium herbariorumof Filamentous Fungi Used for the Manufacture of Karebushi, Dried Bonito (Katsuobushi)

Atrovenetin as a potent antioxidant compound from penicillium species

Effects of protozoa on the antioxidant activity in the ruminal fluid and blood plasma of cattle

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