Metabolites of medicine food homology-derived endophytic fungi and their activities

Zhang, Jun; Zhu, Yan; Si, Jinping; Wu, Ling-Shang

doi:10.1016/j.crfs.2022.10.006

Cited by 15 publications

(5 citation statements)

References 169 publications

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“…The concept of medicine and food homology is based on the advantage of boosting one's immunity, thus achieving the effect of preventing and treating diseases [132,133]. PRA has a long history of medicinal use, and as a dual-purpose herb, it has great development and application value in clinical application, health food and diet [134].…”

Section: Discussionmentioning

confidence: 99%

The Role and Mechanism of Paeoniae Radix Alba in Tumor Therapy

Yang,

Yuan,

Wang

et al. 2024

Molecules

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Tumors have a huge impact on human life and are now the main cause of disease-related deaths. The main means of treatment are surgery and radiotherapy, but they are more damaging to the organism and have a poor postoperative prognosis. Therefore, we urgently need safe and effective drugs to treat tumors. In recent years, Chinese herbal medicines have been widely used in tumor therapy as complementary and alternative therapies. Medicinal and edible herbs are popular and have become a hot topic of research, which not only have excellent pharmacological effects and activities, but also have almost no side effects. Therefore, as a typical medicine and food homology, some components of Paeoniae Radix Alba (PRA, called Baishao in China) have been shown to have good efficacy and safety against cancer. Numerous studies have also shown that Paeoniae Radix Alba and its active ingredients treat cancer through various pathways and are also one of the important components of many antitumor herbal compound formulas. In this paper, we reviewed the literature on the intervention of Paeoniae Radix Alba in tumors and its mechanism of action in recent years and found that there is a large amount of literature on its effect on total glucosides of paeony (TGP) and paeoniflorin (PF), as well as an in-depth discussion of the mechanism of action of Paeoniae Radix Alba and its main constituents, with a view to promote the clinical development and application of Paeoniae Radix Alba in the field of antitumor management.

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Section: Discussionmentioning

confidence: 99%

The Role and Mechanism of Paeoniae Radix Alba in Tumor Therapy

Yang,

Yuan,

Wang

et al. 2024

Molecules

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“…The concept of MFH initially emerged in the Huangdi Neijing (475–221 BC) (Gong et al., 2020). To date, numerous researchers from various countries have investigated MFH (Table 1) (Khan, Huang, et al., 2018; Pinela et al., 2017; Shingnaisui et al., 2018; Xie et al., 2022), which has proven to be an effective means of regulating human health owing to its rich content of natural active ingredients, such as polyphenols, flavonoids, polysaccharides, saponins, alkaloids, and essential oils (Garayev et al., 2018; Lu et al., 2022; Mdkhana et al., 2021; Pan et al., 2021; Zacchino et al., 2017; Zhang, Zhu, et al., 2022). The development of probiotics (Table 2) in recent years has opened up opportunities for MFH, and probiotic‐driven fermentation provides a novel approach to the high‐value and industrialization of MFH, addressing the limitations of its application, such as certain side‐effects, lack of in‐depth studies on its efficacy, low oral bioavailability, and poor flavor (Bohn et al., 2015; Leonard et al., 2021; Lu et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Probiotic‐fermented edible herbs as functional foods: A review of current status, challenges, and strategies

Cui,

Zhang,

Pan

et al. 2024

Comp Rev Food Sci Food Safe

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Recently, consumers have become increasingly interested in natural, health‐promoting, and chronic disease‐preventing medicine and food homology (MFH). There has been accumulating evidence that many herbal medicines, including MFH, are biologically active due to their biotransformation through the intestinal microbiota. The emphasis of scientific investigation has moved from the functionally active role of MFH to the more subtle role of biotransformation of the active ingredients in probiotic‐fermented MFH and their health benefits. This review provides an overview of the current status of research on probiotic‐fermented MFH. Probiotics degrade toxins and anti‐nutritional factors in MFH, improve the flavor of MFH, and increase its bioactive components through their transformative effects. Moreover, MFH can provide a material base for the growth of probiotics and promote the production of their metabolites. In addition, the health benefits of probiotic‐fermented MFH in recent years, including antimicrobial, antioxidant, anti‐inflammatory, anti‐neurodegenerative, skin‐protective, and gut microbiome‐modulating effects, are summarized, and the health risks associated with them are also described. Finally, the future development of probiotic‐fermented MFH is prospected in combination with modern development technologies, such as high‐throughput screening technology, synthetic biology technology, and database construction technology. Overall, probiotic‐fermented MFH has the potential to be used in functional food for preventing and improving people's health. In the future, personalized functional foods can be expected based on synthetic biology technology and a database on the functional role of probiotic‐fermented MFH.

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“…At the same time, the same active components as that of host plants can be obtained from endophytic fungi, such as the vitexin-producing Cajanus cajan, rhein-producing Rheum palmatum L, and huperzine A-producing Huperzia serrata [ [9] , [10] , [11] ]. Therefore, secondary metabolites of endophytic fungi have potential nutritional and medicinal value and may play an important role in pharmaceutical engineering and clinical practice [ 12 ]. However, there is little information on the metabolic communication between endophytic fungi and host plants, and their regulatory mechanisms remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analysis revealing the effect of Bupleurum scorzonerifolium Willd association with endophytic fungi CHS3 on the production of saikosaponin D

Liu,

et al. 2024

Heliyon

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Metabolites of medicine food homology-derived endophytic fungi and their activities

Cited by 15 publications

References 169 publications

The Role and Mechanism of Paeoniae Radix Alba in Tumor Therapy

The Role and Mechanism of Paeoniae Radix Alba in Tumor Therapy

Probiotic‐fermented edible herbs as functional foods: A review of current status, challenges, and strategies

Transcriptome analysis revealing the effect of Bupleurum scorzonerifolium Willd association with endophytic fungi CHS3 on the production of saikosaponin D

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