Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12

Abstract

One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B–C (2,3) and three new α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound 1 had an unusual 5/10/5-fused tricyclic ring system. Compounds 1 and 4 showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC50 values of 21.5 and 12.5 μM, respectively.

Endophytic Fungi: An Effective Alternative Source of Plant-Derived Bioactive Compounds for Pharmacological Studies

“…QYM12. Compound 131 showed significant anti-inflammatory activity by inhibiting LPS-induced NO production in a mouse macrophage cell line RAW264.7, with an IC 50 value of 21.5 µM [75]. The pimarane-type diterpene Libertellenone M 132 (Figure 10) was isolated from the marine source endophytic fungus Phomopsis sp.…”

Secondary Metabolites from Fungi — Honour of Prof. Dr. Ji-Kai Liu's 60th Birthday

“…Three new cyclopiane diterpenes 13β-hydroxy conidiogenone C 18 and 12β-hydroxy conidiogenones C 19 and D 20 have been isolated and identified from a sea sedimentderived fungus Penicillium sp. TJ403-2 [75]. Their absolute configurations were further established by X-ray crystallography experiment.…”

“…An unusual type sesquiterpene 156 possessed an unusual 14(7-6)-cuparane scaffold (Scheme 5), and six rarely-encountered gymnomitrane-type sesquiterpenoids 157-162, were isolated from the medicinal mushroom Ganoderma lingzhi [75]. A new gymnomitrane-type sesquiterpenoid 163 was isolated from the fruiting body of Ganoderma lucidum [76].…”

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

“…Mangrove endophytic fungi, the second largest ecological group of marine fungi, have been reported to produce thousands of new metabolites until now ( Chen et al, 2021 ; Chen et al, 2022 ). Over the past 2 decades, our group continues to explore bioactive novel structures from mangrove endophytic fungi ( Huang et al, 2013 ; Xiao et al, 2013 ; Liu et al, 2016 ; Cui et al, 2017 ; Cai et al, 2019 ).…”