2024
DOI: 10.1186/s12951-024-03057-4
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Metabolizable alloy clusters assemble nanoinhibitor for enhanced radiotherapy of tumor by hypoxia alleviation and intracellular PD-L1 restraint

Guanwen Ding,
Shengnan Liu,
Xiangshan Yang
et al.

Abstract: Background Cancer radiotherapy (RT) still has limited clinical success because of the obstacles including radioresistance of hypoxic tumors, high-dose X-ray–induced damage to adjacent healthy tissue, and DNA-damage repair by intracellular PD-L1 in tumor. Results Therefore, to overcome these obstacles multifunctional core–shell BMS@Pt 2 Au 4 nanoparticles (NPs) are prepared using nanoprecipitation followed by electros… Show more

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