2013
DOI: 10.1371/journal.pone.0078281
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Metabolomic Analysis of Anti-Hypoxia and Anti-anxiety Effects of Fu Fang Jin Jing Oral Liquid

Abstract: BackgroundHerba Rhodiolae is a traditional Chinese medicine used by the Tibetan people for treating hypoxia related diseases such as anxiety. Based on the previous work, we developed and patented an anti-anxiety herbal formula Fu Fang Jin Jing Oral Liquid (FJJOL) with Herba Rhodiolae as a chief ingredient. In this study, the anti-hypoxia and anti-anxiety effects of FJJOL in a high altitude forced-swimming mouse model with anxiety symptoms will be elucidated by NMR-based metabolomics.MethodsIn our experiments, … Show more

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Cited by 31 publications
(23 citation statements)
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“…The antifatigue activities of PHC were detected via forced swimming, forced running and rotating rod assessments. Similar to previous findings in Herba rhodiolae (19), PHC treatment significantly enhanced swimming duration, with a maximum recording of 8.26 min, compared with the duration of 3.01 min in the control group (P<0.001; Fig. 2A).…”
Section: Effects Of Phc On Autonomic Activitysupporting
confidence: 90%
See 1 more Smart Citation
“…The antifatigue activities of PHC were detected via forced swimming, forced running and rotating rod assessments. Similar to previous findings in Herba rhodiolae (19), PHC treatment significantly enhanced swimming duration, with a maximum recording of 8.26 min, compared with the duration of 3.01 min in the control group (P<0.001; Fig. 2A).…”
Section: Effects Of Phc On Autonomic Activitysupporting
confidence: 90%
“…The prevalence of potential alternative medicines derived from herbs have been increasing worldwide, which can be used not only for medicinal purposes, but also for food preservation, as dietary supplements or functional foods, and in cosmetics (17). Herba rhodiolae, a traditional Chinese herb, is commonly used by the Tibetan population for the treatment of hypoxia (19), which also leads to the enhancement of fatigue-associated movements and levels of key metabolites of glycolysis, including ATP (20). Based on previous evidence, the present study hypothesized that PHC-enriched extraction may possess antifatigue and antihypoxic activities.…”
Section: Introductionmentioning
confidence: 99%
“…14 Owing to its high chromatographic resolution, high sensitivity, and rapid separation, ultra-performance liquid chromatography (UPLC) coupled with mass spectrometry (MS) has been used widely in the systematic characterisation of drug targets, thereby helping to reduce the typically high attrition rates in discovery projects. [15][16][17][18][19][20][21] It is a more effective approach by computational integration of different knowledge sources and unprecedent opportunities are provided by plentiful metabolomic data for drug target identification. 22 The core idea of metabolomics is to determine the metabolites of relatively low molecular weight, then to transform the data of metabolic profiles into useful information by pattern recognition tools, and to reveal the essence of diseases and assess therapeutic effects of drug.…”
Section: Introductionmentioning
confidence: 99%
“…Metabolic profiles of animal models were used to reveal changes in energy metabolism with the use of an anti-anxiety herb formula (Liu et al, 2013) and were also used to establish a model to assess neonatal hypoxic injury (Skappak et al, 2013). Comparisons of metabolic profiles of human biofluids from diseased and control patients showed that metabolic profiles can be used in the discovery of biomarkers of disease (Luo et al, 2012) and metabolic profiles of healthy human subjects subjected to 8 h of 12% oxygenation were observed to find the changes relative to HIF-1 and oxidative pressure (Tissot van Patot et al, 2009).…”
Section: Introductionmentioning
confidence: 99%