Metabolomic analysis of Scenedesmus obliquus reveals new insights into the phytotoxicity of imidazolium nitrate ionic liquids

Li, Zhiheng; Chen, Jiazheng; Chen, Jie; Jin, Jiaojun; Chen, Hanmei; Liu, Huijun

doi:10.1016/j.scitotenv.2022.154070

Cited by 14 publications

(11 citation statements)

References 51 publications

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“…Quinolone antibiotics are a class of synthetic antibiotics that can inhibit DNA synthesis by complexing with DNA ligases and synthases [31]. Quinolone antibiotics constituted 13% of the Chinese antibiotic market share in 2017 and have been detected in various environmental media and biological tissues [30]. However, because of their persistence and bioaccumulation, it is difficult and inefficient to remove these pollutants via engineering disposition methods, making it easy for them to be released into aquatic environments and exert toxic effects on aquatic ecosystems [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

“…Wollenberger et al (2000) found that the EC 50 values of penicillin and chlortetracycline for Microcystis were 6 µg/L and 50 µg/L, respectively [35]. Wan et al (1998) compared the effects of moxifloxacin stress and gatifloxacin stress on the growth of Microcystis aeruginosa and found that the 96 h EC 50 values of the two antibiotics were 60.34 and 25.30 µg/L, respectively [30]. These results suggest that microalgae are strongly affected by antibiotics, despite being non-target organisms.…”

Section: Discussionmentioning

confidence: 99%

“…The biomass of the algal cells was calculated using the relationship between the algal cell density and the absorbance obtained from Section 2.3.1. The growth inhibition rate (GIR) was calculated using Equation (1), and the concentration for 50% effect (EC 50 ) was calculated by fitting the Logistic model [30].…”

Section: Determination Of the Growth Inhibition Rate And Ec 50mentioning

confidence: 99%

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Photosynthetic Toxicity of Enrofloxacin on Scenedesmus obliquus in an Aquatic Environment

Zhang

Fang

et al. 2022

IJERPH

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Aquaculture facilities are a potential source of antibiotics in aquatic environments, having adverse effects on the algae species. In this study, the toxicity induced by enrofloxacin (ENR) on the algae Scenedesmus obliquus was evaluated. The uptake of ENR and the change in the growth and photosynthesis of algae were analyzed. At the exposure doses of 10–300 μg/L, the accumulated levels of ENR in algae were 10.61–18.22 μg/g and 12.09–18.34 μg/g after 48 h and 96 h of treatment, respectively. ENR inhibited the growth of algae, with a concentration for 50% effect of 119.74 μg/L, 53.09 μg/L, 64.37 μg/L, and 52.64 μg/L after 24 h, 48 h, 72 h and 96 h of treatment, respectively, indicating the self-protection and repair ability of algae in a short period of time. Furthermore, the chlorophyll contents decreased in all treatment groups, and the photosynthetic system Ⅱ parameters decreased in a dose-dependent manner under ENR stress, suggesting that ENR caused a disorder in the electron transport of the photosynthesis of algae, and the carbon fixation and assimilation processes were thus damaged. These results indicate that ENR poses a considerable risk to aquatic environments, affects the carbon sinks, and even has an adverse effect on human health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Determination Of the Growth Inhibition Rate And Ec 50mentioning

confidence: 99%

See 1 more Smart Citation

Photosynthetic Toxicity of Enrofloxacin on Scenedesmus obliquus in an Aquatic Environment

Zhang

Fang

et al. 2022

IJERPH

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“…The growth inhibition of S. obliuus increased with elongation of alkyl chain length from C 10 to C 12 . Maximum growth inhibition of 94.61 % and 97.34 % occurred when 4 mg L −1 and 8 mg L −1 of concentration of [C 10 mm][NO 3 ] and [C 12 mm][NO 3 ] were used respectively 90. It was reported that the inhibitory concentration (IC 50 ) for [C 10 mm][NO 3 ] was 10‐fold greater than the IC 50 for [C 12 mm][NO 3 ].…”

Section: Structure and Toxicity Correlation Of Ionic Liquidsmentioning

confidence: 99%

“…This was attributed to the removal of magnesium from the chlorophyll, which can affect the process of photosynthesis 111. A decrease in chlorophyll contents in Scenedesmus obliquss was observed when treated with [C 10 mmim][NO 3 ] and [C 12 mmim][NO 3 ] 90.…”

Section: Effect Of Ionic Liquids On the Morphology Of Plantsmentioning

confidence: 99%

An Overview on Phytotoxic Perspective of Ionic Liquids and Deep Eutectic Solvents: The Role of Chemical Structure in the Phytotoxicity

et al. 2023

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Ionic liquids (ILs) and deep eutectic solvents (DESs) are designable solvents having widespread applications. They have gained tremendous attention in the last few decades due to their inherent physicochemical properties, making them distinctive solvents from technological point of view. There are a large number of research articles published on physicochemical properties and applications of ILs and DESs, however, limited research work is available on the phytotoxic effect of ILs and DESs. They are considered as environmentally friendly greener solvents, however, during experimental work, it has been found that they are not always as green as desired. It has been reported that ILs and DESs have phytotoxic properties and effect both aquatic and terrestrial plants. Here the phototoxic problems of ILs and DESs are reviewed. Similar to the traditional solvents, the aforementioned solvents are not safe, and it is important to determine their phytotoxicity prior to highlighting their potential applications. This review will help researchers to design new eco‐friendly ILs and DESs, which can fulfil the twelve principles of green chemistry.

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Ligand‐Independent Activation of Aryl Hydrocarbon Receptor and Attenuation of Glutamine Levels by Natural Deep Eutectic Solvent

Denis,

Toledo,

Hakim

et al. 2023

ChemBioChem

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Natural deep eutectic solvents (NADESs) are emerging sustainable alternatives to conventional organic solvents. Beyond their role as laboratory solvents, NADESs are increasingly explored in drug delivery and as therapeutics. Their increasing applications notwithstanding, our understanding of how they interact with biomolecules at multiple levels – metabolome, proteome, and transcriptome – within human cell remain poor. Here, we deploy integrated metabolomics, proteomics, and transcriptomics to probe how NADESs perturb the molecular landscape of human cells. In a human cell line model, we found that an archetypal NADES derived from choline and geranic acid (CAGE) significantly altered the metabolome, proteome, and transcriptome. CAGE upregulated indole‐3‐lactic acid and 4‐hydroxyphenyllactic acid levels, resulting in ligand‐independent activation of aryl hydrocarbon receptor to signal the transcription of genes with implications for inflammation, immunomodulation, cell development, and chemical detoxification. Further, treating the cell line with CAGE downregulated glutamine biosynthesis, a nutrient rapidly proliferating cancer cells require. The ability of CAGE to attenuate glutamine levels is potentially relevant for cancer treatment. These findings suggest that NADESs, even when derived from natural components like choline, can indirectly modulate cell biology at multiple levels, expanding their applications beyond chemistry to biomedicine and biotechnology.

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Metabolomic analysis of Scenedesmus obliquus reveals new insights into the phytotoxicity of imidazolium nitrate ionic liquids

Cited by 14 publications

References 51 publications

Photosynthetic Toxicity of Enrofloxacin on Scenedesmus obliquus in an Aquatic Environment

Photosynthetic Toxicity of Enrofloxacin on Scenedesmus obliquus in an Aquatic Environment

An Overview on Phytotoxic Perspective of Ionic Liquids and Deep Eutectic Solvents: The Role of Chemical Structure in the Phytotoxicity

Ligand‐Independent Activation of Aryl Hydrocarbon Receptor and Attenuation of Glutamine Levels by Natural Deep Eutectic Solvent

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