2016
DOI: 10.1039/c5mb00637f
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Metabolomic analysis of survival in carbohydrate pre-fed pigs subjected to shock and polytrauma

Abstract: Hemorrhagic shock, a result of extensive blood loss, is a dominant factor in battlefield morbidity and mortality. Early rodent studies in hemorrhagic shock reported carbohydrate feeding prior to the induction of hemorrhagic shock decreased mortality. When repeated in our laboratory with a porcine model, carbohydrate pre-feed resulted in a 60% increase in death rate following hemorrhagic shock with trauma when compared to fasted animals (15/32 or 47% vs 9/32 or 28%). In an attempt to explain the unexpected deat… Show more

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Cited by 2 publications
(3 citation statements)
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“…Furthermore, decreased lipid synthesis and urea cycle activity in the liver as well as increased hyperglycemia and lactic- and keto-acidosis have been shown to occur after injury (21, 90). These have been noted in fasting and fed states (24, 91, 92). Clinical care can both affect the metabolic response after trauma and be informed by changes in metabolic profiles.…”
Section: Clinical Applications Of Metabolomics In Trauma Researchmentioning
confidence: 77%
See 1 more Smart Citation
“…Furthermore, decreased lipid synthesis and urea cycle activity in the liver as well as increased hyperglycemia and lactic- and keto-acidosis have been shown to occur after injury (21, 90). These have been noted in fasting and fed states (24, 91, 92). Clinical care can both affect the metabolic response after trauma and be informed by changes in metabolic profiles.…”
Section: Clinical Applications Of Metabolomics In Trauma Researchmentioning
confidence: 77%
“…Traditionally, high-field NMR has been the method of choice in metabolomic investigations (2123). In fact, most of the published investigations involving the metabolic studies of trauma have relied on 1 H NMR (2124). NMR is highly quantitative which allows the acquired data to be extremely reproducible.…”
Section: Metabolomics and Data Acquisitionmentioning
confidence: 99%
“…Lacking specific therapies for traumatic injury, early treatment is a key to improving survival. Metabolomics has already been successfully used to identify succinate, an objective biomarker of mortality, to improve triage [20][21][22]. However, new technology needs to be developed to bring succinate detection and quantification to the clinic.…”
Section: Pc2 and Pc3 Show A Clear Separation Between Samples From Tramentioning
confidence: 99%