Metabolomic analysis reveals the impact of ketoprofen on carbon and nitrogen metabolism in rice (Oryza sativa L.) seedling leaves

Wang, Huan; Li, Zhiheng; Chen, Hanmei; Jin, Jiaojun; Zhang, Ping; Shen, Luoqin; Hu, Shuhao; Liu, Huijun

doi:10.1007/s11356-022-23716-z

Cited by 6 publications

(4 citation statements)

References 56 publications

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“…It resulted in changes in photosynthetic pigment content, altered expression of genes related to chlorophyll synthesis and the photosynthetic electron transport chain, hindered growth, and caused damage to the root system. Subsequent metabolomic analysis revealed that KTP negatively impacted the respiration rate, ATP synthesis, and disrupted carbon and nitrogen metabolism, leading to changes in key enzymes involved in these processes ( Wang et al, 2023 ). In another study, KTP and a mixture of KTP and ibuprofen had significant effects on spring barley ( Hordeum vulgare L.), namely reduced growth potential, root length, fresh weight yield, altered levels of chlorophylls and carotenoids, and induced oxidative stress ( Pawłowska et al, 2023 ).…”

Section: Ecotoxic Effects Of Ketoprofenmentioning

confidence: 99%

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Tyumina,

Subbotina,

Polygalov

et al. 2023

Front. Microbiol.

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Ketoprofen, a bicyclic non-steroidal anti-inflammatory drug commonly used in human and veterinary medicine, has recently been cited as an environmental contaminant that raises concerns for ecological well-being. It poses a growing threat due to its racemic mixture, enantiomers, and transformation products, which have ecotoxicological effects on various organisms, including invertebrates, vertebrates, plants, and microorganisms. Furthermore, ketoprofen is bioaccumulated and biomagnified throughout the food chain, threatening the ecosystem function. Surprisingly, despite these concerns, ketoprofen is not currently considered a priority substance. While targeted eco-pharmacovigilance for ketoprofen has been proposed, data on ketoprofen as a pharmaceutical contaminant are limited and incomplete. This review aims to provide a comprehensive summary of the most recent findings (from 2017 to March 2023) regarding the global distribution of ketoprofen in the environment, its ecotoxicity towards aquatic animals and plants, and available removal methods. Special emphasis is placed on understanding how ketoprofen affects microorganisms that play a pivotal role in Earth’s ecosystems. The review broadly covers various approaches to ketoprofen biodegradation, including whole-cell fungal and bacterial systems as well as enzyme biocatalysts. Additionally, it explores the potential of adsorption by algae and phytoremediation for removing ketoprofen. This review will be of interest to a wide range of readers, including ecologists, microbiologists, policymakers, and those concerned about pharmaceutical pollution.

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Section: Ecotoxic Effects Of Ketoprofenmentioning

confidence: 99%

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Tyumina,

Subbotina,

Polygalov

et al. 2023

Front. Microbiol.

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“…Soluble carbohydrate content is an important indicator of carbon conversion and accumulation in plants [ 7 ], which strongly influences plant resistance to abiotic stresses, provides essential energy and carbon skeletons for plant nitrogen metabolism, and provides essential energy for plant growth and metabolism [ 36 ]. Our results indicate that different genotypes of maize seedlings showed significant differences in carbon metabolism during Mn deficiency, with the tolerant genotype maintaining a higher level of carbon metabolism as Mn deficiency stress increased, compared to the sensitive genotype.…”

Section: Discussionmentioning

confidence: 99%

“…Nitrogen assimilation requires reduced ferredoxin, ATP, and NADH produced by photoreaction, as well as the synthesis of amino acids using keto acids synthesized by carbon metabolism as carbon skeletons ( Figure 9 ). Concurrently, carbon metabolism requires nitrogen assimilation to provide the necessary organic substances such as enzymes and proteins [ 38 ]; for example, Rubisco activity and chlorophyll content are closely related to nitrogen assimilation [ 36 ]. In this study, the C/N of the tolerant genotype increased significantly during Mn deficiency, whereas that of the sensitive genotype showed an increase and then a decrease; the root C/N showed a significant increase, and the sensitive genotype presented a greater degree of increase.…”

Section: Discussionmentioning

confidence: 99%

Effect of Mn Deficiency on Carbon and Nitrogen Metabolism of Different Genotypes Seedlings in Maize (Zea mays L.)

Tao

Liu

Piao

et al. 2023

Plants

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Manganese deficiency critically impairs the function and stability of photosystem II (PSII) and negatively impacts crop growth and yield. However, the response mechanisms of carbon and nitrogen metabolism to Mn deficiency in different genotypes of maize and the differences in Mn deficiency tolerance are unclear. Herein, three different genotypes of maize seedlings (sensitive genotype: Mo17, tolerant genotype: B73, and B73 × Mo17) were exposed to Mn deficiency treatment for 16 days using liquid culture with different concentrations of MnSO4 [0.00, 2.23, 11.65, and 22.30 mg/L (control)]. We found that complete Mn deficiency significantly reduced maize seedling biomass; negatively affected the photosynthetic and chlorophyll fluorescence parameters; and depressed nitrate reductase, glutamine synthetase, and glutamate synthase activity. This resulted in reduced leaf and root nitrogen uptake, with Mo17 being most severely inhibited. B73 and B73 × Mo17 maintained higher sucrose phosphate synthase and sucrose synthase activities and lower neutral convertase activity compared to Mo17, which resulted in higher accumulation of soluble sugars and sucrose and maintenance of the osmoregulation capacity of leaves, which helped mitigate damage caused by Mn deficiency. The findings revealed the physiological regulation mechanism of carbon and nitrogen metabolism in different genotypes of maize seedlings that resist Mn deficiency stress, providing a theoretical basis for developing high yield and quality.

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“…Nanoplastics have been found to be associated with overproduction of reactive oxygen species in cells. NPs inside cells induced changes in different metabolic activities such as the TCA cycle, oxidative phosphorylation, degradation of fatty acid, metabolism related to amino acids and carbon [ 22 , 23 ]. Various metabolic pathways involving enzymes and proteins, biomarkers in the TCA cycle, amino acid, lipid, and nucleotide metabolism are either downregulated or upregulated depending on the concentrations and interaction with NPs [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoplastics Toxicity Specific to Liver in Inducing Metabolic Dysfunction—A Comprehensive Review

Haldar

Yhome

Muralidaran

et al. 2023

Genes

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Plastic pollution in the world is widespread and growing. The environment is swamped with nanoplastics (<100 nm), and the health consequences of these less visible pollutants are unknown. Furthermore, there is evidence that microplastics can release nanoplastics by digestive disintegration, implying that macroplastic exposure can cause direct and indirect disease via nanoplastics. The existence and impact of nanoplastics in numerous tissues from invertebrates to larger vertebrates that consume significant amounts of plastics were investigated, and histopathological techniques were utilized to determine physiological reactions and inflammation from the plastics. Nanoplastics enters an organism through the respiratory and gastro-intestinal tract where they accumulate into the liver through blood circulation via absorption, or epidermal infiltration. It is stated that macroplastics can cause damage directly at the site of exposure, whereas nanoplastics can influence the liver, causing subsequent damage to other organs. Multi-organ dysfunction is brought on by liver changes, and nanoplastics can readily enter the gut-liver axis and disturb the gut microflora. By exploring the literature and summarizing the research that has been published to date, this review article reveals the deleterious effect and mechanisms of nanoplastics on the pathophysiological functions of the hepatic system.

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Metabolomic analysis reveals the impact of ketoprofen on carbon and nitrogen metabolism in rice (Oryza sativa L.) seedling leaves

Cited by 6 publications

References 56 publications

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Effect of Mn Deficiency on Carbon and Nitrogen Metabolism of Different Genotypes Seedlings in Maize (Zea mays L.)

Nanoplastics Toxicity Specific to Liver in Inducing Metabolic Dysfunction—A Comprehensive Review

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