Metabolomic and biotechnological approaches to determine therapeutic potential of Withania somnifera (L.) Dunal: A review

Discrimination of Different Parts of Saffron by Metabolomic‐Based Ultra‐Performance Liquid Chromatography Coupled with High‐Definition Mass Spectrometry

“…Metabolomics (or metabonomics) belong to one of component of systems biology. Recent technological advances have enabled rapid and systematic identification of a large myriad of metabolites or compounds by using sensitive and high‐throughput metabolomic techniques . Metabolomics has the potential to facilitate an understanding and illuminating of the action mechanisms of TCM .…”

“…Recent technological advances have enabled rapid and systematic identification of a large myriad of metabolites or compounds by using sensitive and high-throughput metabolomic techniques. [19][20][21][22][23][24] Metabolomics has the potential to facilitate an understanding and illuminating of the action mechanisms of TCM. [25] Although various mass spectrometry platforms could be used for metabolomics, ultra-performance liquid chromatography coupled with high-definition mass spectrometry (UPLC-HDMS) has been considered to be more suitable for analyzing the metabolite profiling and metabolite identification due to its enhanced reproducibility of retention time.…”

Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis

“…Ashwagandha (Withania somnifera) is a plant in the Solanaceae family. The extract of the Ashwagandha root has many biological implications due to its diverse phytochemicals [11], so it has been used, singly or in combination with other natural plants, in many research studies for its properties: anti-diabetic [12], anti-inflammatory [13], anti-microbial [14], anti-tumor [15], anti-stress [16], cardioprotective [17], or neuroprotective [18]. It also displays enhanced endothelial function [11], reduces reactive oxygen species [13], regulates apoptosis [19], and modulates mitochondrial function [11], showing to be effective to treat aging effects [20], anxiety and stress [21], arthritis [22], cognitive functions and memory [23], diabetes [12], epilepsy [24], fatigue [25], neurodegenerative diseases [26], pain [27], thyroid function [28], and skin diseases [29].…”

Neuroprotective Effect of CR-777, a Glutathione Derivative of Withaferin A, Obtained through the Bioconversion of Withania somnifera (L.) Dunal Extract by the Fungus Beauveria bassiana

“…Beyond neuroprotection [6,7], many activities were reported for Withania somnifera extracts or pure compounds, including antibacterial, anticancer, antidiabetic, cardioprotective, and anti-inflammatory properties [5]. Several patents on different compositions of plant extracts have been filed [8]; however, no single pharmacological compound has been developed to date.…”

“…However, in neurodifferentiation, neuroprotection, and neuroregeneration, withaferin A is not the most active constituent compared to withanolide A and withanoside IV ( Figure 1) [4]. patents on different compositions of plant extracts have been filed [8]; however, no single pharmacological compound has been developed to date. Since many side and adverse effects are suspected for Whitania extracts, and considering the widespread use of the plant in traditional medicine, extensive studies were undertaken to regulate the traditional use of the plant.…”