Metabolomic fingerprinting and genetic discrimination of four Hypericum taxa from Greece

Ζέλιου, Κωνσταντίνα; Koui, Eirini-Maria; Papaioannou, Charikleia; Koulakiotis, Nikolaos Stavros; Iatroú, Gregoris; Tsarbopoulos, Anthony; Papasotiropoulos, Vasileios; Lamari, Fotini N.

doi:10.1016/j.phytochem.2020.112290

Cited by 21 publications

(12 citation statements)

References 72 publications

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“…depilatum [29,30], H. empetrifolium ssp. empetrifolium [31], H. reflexum, H. canariense and H. grandifolium [32], H. asperulum [33], H. gaiti [34], H. pruinatum [30], H. origanifolium [35], H. laricifolium [36], H. japonicum [37], H aegypticum subdp. webii [38], H. amblyocalyx and H. jovis [39], H. hemsleyanum [40], H. hookerianum and H. bellum [24], H. rochelii and H. umbellatum [41], and H. hyssopifolium ssp.…”

Section: Resultsmentioning

confidence: 99%

“…H. perforatum ssp. veronense oil from Croatia showed αpinene and n-nonane as the major constituents [49], while the oil from Greece yielded high amounts of selinenes [31]. Some homogeneity is reported for the composition of the EO of H. scabrum from different collection sites, showing that α-pinene is the most represented compound (Table 1).…”

Section: Chemical Constituents Of Hypericum Spp Eosmentioning

confidence: 95%

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Hypericum Essential Oils—Composition and Bioactivities: An Update (2012–2022)

et al. 2022

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Hypericum genus, considered to comprise over 500 species that exhibit cosmopolitan distribution, has attracted human interest since ancient times. The present review aims to provide and summarize the recent literature (2012–2022) on the essential oils of the title genus. Research articles were collected from various scientific databases such as PubMed, ScienceDirect, Reaxys, and Google Scholar. Scientific reports related to the chemical composition, as well as the in vitro and in vivo pharmacological activities, are presented, also including a brief outlook of the potential relationship between traditional uses and Hypericum essential oils bioactivity.

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Section: Resultsmentioning

confidence: 99%

Section: Chemical Constituents Of Hypericum Spp Eosmentioning

confidence: 95%

Hypericum Essential Oils—Composition and Bioactivities: An Update (2012–2022)

et al. 2022

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“…Although the chemical composition of H. perforatum essential oils has been reported previously in several publications [9,11,[32][33][34][35][36][37][38][39], there is a wide variation in the reported levels of secondary metabolites from different H. perforatum plant samples (see Table 1 for a summary of results from recent studies since 2010). This variability can impact the specific pharmacological activity of essential oils/extracts [40,41].…”

Section: Essential Oil Compositionmentioning

confidence: 99%

Chemical Composition and Immunomodulatory Activity of Hypericum perforatum Essential Oils

Schepetkin

Özek

et al. 2020

Biomolecules

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Hypericum L. (Hypericaceae) extracts have been used for their therapeutic effects; however, not much is known about the immunomodulatory activity of essential oils extracted from this plant. We isolated essential oils from the flowers and leaves of H. perforatum and analyzed their chemical composition and innate immunomodulatory activity. Analysis of flower (HEOFl) versus leaf (HEOLv) essential oils using gas chromatography–mass spectrometry revealed that HEOFl was comprised mainly of monoterpenes (52.8%), with an abundance of oxygenated monoterpenes, including cis-p-menth-3-en-1,2-diol (9.1%), α-terpineol (6.1%), terpinen-4-ol (7.4%), and limonen-4-ol (3.2%), whereas the sesquiterpenes were found in trace amounts. In contrast, HEOLv was primarily composed of sesquiterpenes (63.2%), including germacrene D (25.7%) and β-caryophyllene (9.5%). HEOLv also contained oxygenated monoterpenes, including terpinen-4-ol (2.6%), while monoterpene hydrocarbons were found in trace amounts. Both HEOFl and HEOLv inhibited neutrophil Ca2+ mobilization, chemotaxis, and reactive oxygen species (ROS) production, with HEOLv being much more active than HEOFl. Furthermore, the pure sesquiterpenes germacrene D, β-caryophyllene, and α-humulene also inhibited these neutrophil responses, suggesting that these compounds represented the active components of HEOLv. Although reverse pharmacophore mapping suggested that potential protein targets of germacrene D, β-caryophyllene, bicyclogermacrene, and α-humulene could be PIM1 and mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MAPKAK2), a kinase binding affinity assay did not support this finding, implying that other biological targets are involved. Our results provide a cellular and molecular basis to explain at least part of the beneficial immunotherapeutic properties of the H. perforatum essential oils.

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“…Thus, it should be stabilized during and after the extraction by the addition of ascorbic palmitate or a mixture of ascorbic and citric acids, via transformation to weak salt by dicyclohexylamine base, or through transfer to methanol [ 164 ]. Moreover, it is unstable under heat, air, and light, indicating ambient temperature, absence of light and air as the best extraction and storage conditions, and as necessary precautions of analysis [ 159 , 165 , 167 ]. Furthermore, a 20% loss of the compound was observed when exposing the plant flowers to light for 2 h, while drying under dark had no effect [ 167 ].…”

Section: St John’s Wortmentioning

confidence: 99%

Six Common Herbs with Distinctive Bioactive, Antioxidant Components. A Review of Their Separation Techniques

et al. 2021

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Rosemary, oregano, pink savory, lemon balm, St. John’s wort, and saffron are common herbs wildly grown and easily cultivated in many countries. All of them are rich in antioxidant compounds that exhibit several biological and health activities. They are commercialized as spices, traditional medicines, or raw materials for the production of essential oils. The whole herbs or the residues of their current use are potential sources for the recovery of natural antioxidant extracts. Finding effective and feasible extraction and purification methods is a major challenge for the industrial production of natural antioxidant extracts. In this respect, the present paper is an extensive literature review of the solvents and extraction methods that have been tested on these herbs. Green solvents and novel extraction methods that can be easily scaled up for industrial application are critically discussed.

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Metabolomic fingerprinting and genetic discrimination of four Hypericum taxa from Greece

Cited by 21 publications

References 72 publications

Hypericum Essential Oils—Composition and Bioactivities: An Update (2012–2022)

Hypericum Essential Oils—Composition and Bioactivities: An Update (2012–2022)

Chemical Composition and Immunomodulatory Activity of Hypericum perforatum Essential Oils

Six Common Herbs with Distinctive Bioactive, Antioxidant Components. A Review of Their Separation Techniques

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