2020
DOI: 10.1016/j.cardfail.2020.07.010
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Metabolomic Profile in HFpEF vs HFrEF Patients

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Cited by 63 publications
(58 citation statements)
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“…For example, the biological processes of MLYCD , FKBP5 , PRKCD , and GDA were associated with energy metabolism and immune response, while those of SERPINE1 were associated with the inflammatory response. This was consistent with the pathological phenotypes, including immune dysregulation, metabolic dysfunction, and activation of chronic inflammation, of various tissues in patients with HFpEF ( Hage et al, 2020 ; Sava et al, 2020 ; Schiattarella et al, 2021 ).…”
Section: Resultssupporting
confidence: 87%
“…For example, the biological processes of MLYCD , FKBP5 , PRKCD , and GDA were associated with energy metabolism and immune response, while those of SERPINE1 were associated with the inflammatory response. This was consistent with the pathological phenotypes, including immune dysregulation, metabolic dysfunction, and activation of chronic inflammation, of various tissues in patients with HFpEF ( Hage et al, 2020 ; Sava et al, 2020 ; Schiattarella et al, 2021 ).…”
Section: Resultssupporting
confidence: 87%
“…Our findings are consistent with a study in a murine HFpEF model of metabolic disorder, in which researchers found that β-hydroxybutyrate was an effective treatment, as it targets the acetyl-CoA pool and mitochondrial acetylation ( 32 ). Furthermore, a clinical study including 46 patients with new-onset HFpEF and 75 patients with new-onset HFrEF revealed 11 plasma metabolites that differed between the two groups, and proposed that the hearts of patients with HFpEF tended to show increased rates of fibrosis, oxidative stress, and inflammation compared with those of patients with HFrEF ( 33 ). Together, these results suggested that metabolic pathways could be effective targets for HFpEF therapy.…”
Section: Discussionmentioning
confidence: 99%
“…Non‐cardiac comorbidities are frequently present in elderly HF patients, and the comorbidities including metabolic disorders such as cachexia have profound impacts on plasma metabolites. 12 , 13 , 19 Although plasma metabolites in cancer patients with cachexia were analysed in several earlier studies, the association of plasma amino acids with cachexia in HF patients has not been examined. An attempt to examine the association may lead to the development of a plasma marker of cachexia.…”
Section: Introductionmentioning
confidence: 99%