Metabolomic Profile in the Aqueous Humor of Congenital Ectopia Lentis

Abstract

N−stearoyl valine Eicosanoyl−EA Glabrol Phosphoglycolic acid O−Phospho−4−hydroxy−L−threonine 1−(Malonylamino)cyclopropanecarboxylic acid Phosphohydroxypyruvic acid Aspartyl−Histidine 2−Aminoethylphosphonic acid 2−Methoxybenzenethiol 3−Hydroxynitrazepam 2−Butanone, 4−[6−(sulfooxy)−2−naphthalenyl]− 2−[(Ethylthio)methyl]furan (R)−(+)−2−Pyrrolidone−5−carboxylic acid Oxoglutaric acid N−Acetyl−L−aspartic acid b−D−Glucopyranosiduronic acid Phenethylamine glucuronide S−Lactoylglutathione 2,7−Anhydro−alpha−N−acetylneuraminic acid Fructoselysine Voriconazole N−Desmethylzolmitriptan Streptamine phosphate N−(1−Deoxy−1−fructosyl)valine Hydroxypropionylcarnitine Mannopine N−(1−Deoxy−1−fructosyl)isoleucine N−(1−Deoxy−1−fructosyl)leucine hept−2−enedioic acid L−Ascorbic acid−2−glucoside Ethyl glucuronide 3−Hydroxyadipic acid Methyl5−(but−3−en−1−yl)amino−1,3,4−oxadiazole−2−carboxylate 3−Acrylamidopropyl trimethylammonium Alanyl−Arginine Mimosine 3−(1−Hydroxymethyl−1−propenyl)pentanedioic acid Diethyl Oxalpropionate Citrinin Graveolinine 1−(Indol−3−yl)propanol 3−phosphate Scandinone Monoglyceride citrate (R)−2−Hydroxybutane−1,2,4−tricarboxylate 4−Carboxy−4−hydroxy−2−oxoadipate Acetyl−D−carnitine Glycerol 1−propanoate diacetate N−(2−Hydroxyethyl)iminodiacetic acid Castanospermine Petunidin Pelargonidin SC−514 Flupyrsulfuron−methyl sodium 2−C−Methyl−D−erythritol 2,4−cyclodiphosphate erythro−8,10−Heptacosanediol OH−Diaponeurosporene glucoside ester PA(12:0/15:0) 4−Carboxy−4'−sulfoazobenzene Aminomalonic acid 3,5−DINITROCATECHOL (OR−486) N−Acetylaspartylglutamic acid 2−Aminoadenosine Ceriporic acid B 2−Fluorobenzoate Inosine Allopurinol−1−ribonucleoside Hypoxanthine gamma−Glutamyl−beta−aminopropiononitrile 1,5−Dibutyl methyl hydroxycitrate Ceriporic acid A 1−O−(2R−hydroxy−octadecyl)−sn−glycerol O−6−deoxy−a−L−galactopyranosyl−(1−>2)−O−b−D−galactopyranosyl−(1−>3)−2−(acetylamino)−1,5−anhydro−2−deoxy−D−arabino−Hex−1−enitol Bosentan N−methylundec−10−enamide (3R,6S)−3−Hydroxy−1,7−dioxaspiro[5.5]undecane Gabapentin 2−octenal 7−undecynoic acid 12−amino−dodecanoic acid 2−Dodecylbenzenesulfonic acid N−Undecylbenzenesulfonic acid Ro 31−7549 cis−Resveratrol 3−sulfate 9−B1−PhytoP Kynurenic acid Dibutyl phthalate Phthalic acid Uridine N−Methyl−4−pyridone−3−carboxamide dihydrocapsaicin Type IV cyanolipid 16:0 ester N−goshuyoyl lysine cis− and trans−5−Ethyl−4−methyl−2−(2−butyl)−thiazoline Ethyl 3−(N−butylacetamido)propionate 7−oxo−8−amino−nonanoic acid (E)−2−Butenyl−4−methyl−threonine PELLETIERINE Methylthiobenzoic acid Niacinamide (S,Z)−Lyratol acetate Coutaric acid Chrycolide Itaconic acid 4−(4−Deoxy−alpha−D−gluc−4−enuronosyl)−D−galacturonate 4−Nitroquinoline−1−oxide Leu−Leu−Tyr lipoamide Baclofen Propionylcarnitine 3,4−Dihydro−2H−1−benzopyran−2−one 3−(4−Methyl−3−pentenyl)thiophene L−Histidine D−(−)−Arabinose trans−2−[(Dimethylamino)methylimino]−5−[2−(5−nitro−2− furyl)−vinyl]−1,3,4−oxadiazole N−Acetylmuramoyl−Ala KINETIN RIBOSIDE (E)−C−HDMAPP Cystamine L−Acetylcarnitine DL−Acetylcarnitine Butyrylcarnitine 2−Carboxy−4−dodecanolide Chrycorin allopurin...

Critical Factors in Sample Collection and Preparation for Clinical Metabolomics of Underexplored Biological Specimens

“…The investigation of biomarkers from the AH and VH provides a deeper understanding of ocular diseases, including Glaucoma [ 50 ], Congenital Ectopia Lentis [ 51 ], and Diabetic Retinopathy [ 52 , 53 ]. Nonetheless, tears have been the non-invasive biological specimen of choice to find potential biomarkers in systemic diseases such as Type 2 diabetes mellitus (T2DM) [ 36 , 54 ], and ocular disorders (Keratoconjunctivitis [ 55 ] and Keratoconus [ 56 ]).…”