Metabolomic profile of term infants of gestational diabetic mothers

Dani, Carlo; Bresci, Cecilia; Berti, Elettra; Ottanelli, Serena; Mello, Giorgio; Mecacci, Federico; Breschi, Rita; Hu, Xiaoyu; Tenori, Leonardo; Luchinat, Claudio

doi:10.3109/14767058.2013.823941

Cited by 52 publications

(88 citation statements)

References 28 publications

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“…The increasing risks of perinatal morbidity and mortality, and maternal obstetric complications with a gestational age beyond 38-39 weeks make the management of the post-term pregnancy an important issue in obstetrics [1,2,3,4]. Post-term pregnancy, by definition, refers to a pregnancy that has extended to or beyond 42 weeks of gestation.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Cesarean Delivery after Induction of Labor in Nulliparous Women with an Unfavorable Cervix at or beyond 41 Weeks of Gestation

Son

Kim

Kwon

et al. 2013

Gynecol Obstet Invest

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Aims: To investigate risk factors for cesarean section (CS) following labor induction in nulliparas with an unfavorable cervix at or beyond 41 weeks of gestation. Methods: In this retrospective cohort study, a total of 276 nulliparas with an unfavorable cervix (Bishop score ≤6) who underwent labor induction for prolonged pregnancies were included out of a total of 646 patients who delivered ≥41 weeks (2002-2011). Results: 82 (29.7%) patients of the 276 delivered by CS. The patients who underwent CS had less cervical dilatation and a lower Bishop score on admission than those patients who delivered vaginally (0.76 ± 0.47 vs. 0.92 ± 0.58 cm, p = 0.03 and 1.16 ± 1.25 vs. 1.51 ± 1.34, p = 0.04, respectively). Neonatal birth weight and biparietal diameter (BPD) were significantly smaller in the vaginal delivery group (3,414.93 ± 361.37 vs. 3,534.81 ± 383.05 g, p = 0.01 and 9.43 ± 0.35 vs. 9.65 ± 0.42 cm, p < 0.01). After multiple logistic regression analysis, maternal height, BPD, and early rupture of membranes (ROM) were independently related with CS. Early ROM was defined as spontaneous ROM that occurred before the onset of the active phase of labor. Conclusion: Maternal height, BPD, and early ROM were risk factors for CS following labor induction in nulliparas at or beyond 41 weeks of gestation.

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Section: Introductionmentioning

confidence: 99%

Risk Factors for Cesarean Delivery after Induction of Labor in Nulliparous Women with an Unfavorable Cervix at or beyond 41 Weeks of Gestation

Son

Kim

Kwon

et al. 2013

Gynecol Obstet Invest

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“…Fetal age was determined from crown-rump length measurements made before 12 weeks, MA, as previously described [12] or from a composite of the BPD, HC, AC and FDL measurements obtained before 16 weeks, MA [6]. …”

Section: Methodsmentioning

confidence: 99%

“…Fetal weights were estimated primarily using the four parameters (BPD, HC, AC and FDL] method of Hadlock et al [14]. However, in cases with abnormal second trimester growth velocities [6], other Hadlock weight estimation functions with parameters having normal velocities or the method of Deter et al [15], utilizing the head and abnorminal cubes (Hcube, Acube) estimated from conventional biometric measurements [16], were used. Only 17/184 (9.2%) required alternative weight estimation procedures.…”

Section: Methodsmentioning

confidence: 99%

“…These growth velocities specify Rossavik size models that provide individualized third trimester size standards and predicted birth characteristics (eliminating most between-individual variability) for up to 13 size parameters [6,7]. IGA also permits direct comparisons of fetal and neonatal growth outcome assessments on a personalized basis.…”

Section: Introductionmentioning

confidence: 99%

“…Percent Deviations (%Dev), the difference between expected and measured values (expressed as a percentage of the expected value (Figure 1)) are used in these comparisons [6]. Age-specific reference ranges, determined by measurement errors, modeling errors and the biological variability associated with following a predicted growth trajectory, have been established for thirteen anatomical parameters [6]. Growth pathology is then quantified by measuring the component of %Dev outside the appropriate reference range (Figure 1), called the pathological Percent Deviation (%Dev p ) [8].…”

Section: Introductionmentioning

confidence: 99%

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Fetal growth pathology score: a novel ultrasound parameter for individualized assessment of third trimester growth abnormalities

Deter

Lee

Kingdom

et al. 2017

The Journal of Maternal-Fetal & Neonatal Medicine

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Objectives To study fetal growth in pregnancies at risk for growth restriction (GR) using, for the first time, the fetal growth pathology score (FGPS1). Methods A retrospective cohort study of GR was carried out in 184 selected SGA singletons using a novel, composite measure of growth abnormalities termed the FGPS1. Serial fetal biometry was used to establish second trimester Rossavik size models and determine FGPS1 values prior to delivery. FGPS1 data were compared to neonatal growth outcomes assessed using growth potential realization index (GPRI) values (average negative pathological GPRI (av – pGPRI)). Growth at the end of pregnancy was evaluated from differences in negative, individual composite prenatal growth assessment scores (-icPGAS) measured at the last two ultrasound scans. The FGPS1 and av – pGPRI values were used to classify fetal growth and neonatal growth outcomes, respectively, as Normal (N) or Abnormal (A). Results The risk of neonatal GR (based on birth weight (BW)) was moderate (MR: between 5th and10th percentiles (n=113)) or significant (SR:<5th percentile) (n=71)). Individual pregnancies were grouped into four categories, two representing agreement (N–N (29%), A–A (40%)) and two representing discordance (N–A (11%), A–N (20%)). In the largest and most variable subgroup (A–A,<5%tile, n=49), there was a statistically significant correlation (0.63, p<.0001) between the FGPS1 and av – pGPRI. In N–A, all 20 cases (100%) had long last-scan-to-delivery intervals (1.9 weeks or greater), suggesting late development of the growth abnormality. For A–N, in approximately equal proportions, GR was improving, progressing or unclassifiable at the end of pregnancy. Conclusions Significant agreement between prenatal and postnatal growth assessments was found using a novel approach for quantifying fetal growth pathology (FGPS1). Discordances appear to be due to lack of appropriate prenatal scans or an inadequate set of neonatal measurements. Evidence for a quantitative relationship between assessment methods was seen in the largest and most variable subgroup. The FGPS1 has the potential for characterizing GR in the third trimester and may provide a means for predicting the severity of corresponding abnormal neonatal growth outcomes.

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Hochdurchsatz‐Metabolomik mit 1D‐NMR

et al. 2018

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Metabolomik befasst sich mit der Gesamtheit aller Metabolite, dem Metabolom. Als eine der “Omics”‐Wissenschaften hat sie Querbeziehungen zur Biologie, Physiologie, Pathologie und Medizin; andererseits sind Metabolite chemische Verbindungen, kleine organische Moleküle oder anorganische Ionen. Ihre korrekte Identifizierung und Quantifizierung in komplexen biologischen Matrizen erfordert daher eine solide chemische Grundlage. Im Vergleich beispielsweise zu DNA unterliegen Metabolite sehr viel stärker der Oxidation oder dem enzymatischen Abbau: Wir können große Teile eines Mammut‐Genoms aus einer kleinen Probe rekonstruieren, sind aber nicht in der Lage, dasselbe mit seinem Metabolom zu tun, das innerhalb weniger Stunden nach dem Tod des Tieres wahrscheinlich weitgehend abgebaut war. Erforderlich sind daher Standardverfahren, gute chemische Fertigkeiten der Probenvorbereitung für die Lagerung und anschließende Analyse, genaue analytische Protokolle, eine umfangreiche Kenntnis der Chemometrie, erweiterte statistische Verfahren und fundiertes Wissen über mindestens eine der beiden Metabolomik‐typischen Verfahren, MS oder NMR. All diese Fertigkeiten besitzen traditionell die Chemiker. Entsprechend betrachten wir die Metabolomik aus chemischer Perspektive und beschränken uns auf NMR. Der Analytiker findet Argumente für und gegen NMR, jedoch bietet das Verfahren eine besondere ganzheitliche Perspektive, die für künftige Anwendungen als eine bevölkerungsweite Screeningtechnik für Reihenuntersuchungen sprechen.

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Metabolomic profile of term infants of gestational diabetic mothers

Abstract: Our results suggest that prolonged fetal exposure to hyperglycemia during pregnancy can change neonatal metabolomic profile at birth without affecting the clinical course.

Cited by 52 publications

References 28 publications

Risk Factors for Cesarean Delivery after Induction of Labor in Nulliparous Women with an Unfavorable Cervix at or beyond 41 Weeks of Gestation

Risk Factors for Cesarean Delivery after Induction of Labor in Nulliparous Women with an Unfavorable Cervix at or beyond 41 Weeks of Gestation

Fetal growth pathology score: a novel ultrasound parameter for individualized assessment of third trimester growth abnormalities

Hochdurchsatz‐Metabolomik mit 1D‐NMR

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