Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B

Lu, Yonghai; Zheng, Yue; Liu, Xinru; Liang, Xin; Ngai, Sai-Ming; Li, Tiejun; Zhang, Wei‐Dong

doi:10.1186/1749-8546-7-6

Cited by 16 publications

(14 citation statements)

References 28 publications

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“…Protective effects of Sal-B against MI and I/R injury Similarly to Sal-A, Sal-B has demonstrated cardioprotective effects on cardiac ischemic injury [187,[280][281][282] and reperfusion injury [283][284][285][286][287][288] .…”

Section: Salvianolic Acid Bmentioning

confidence: 99%

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

2018

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Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses broad cardiovascular and cerebrovascular protective actions and has been used in Asian countries for many centuries. Accumulating evidence suggests that Danshen and its components prevent vascular diseases, in particular, atherosclerosis and cardiac diseases, including myocardial infarction, myocardial ischemia/reperfusion injury, arrhythmia, cardiac hypertrophy and cardiac fibrosis. The published literature indicates that lipophilic constituents (tanshinone I, tanshinone IIa, tanshinone IIb, cryptotanshinone, dihydrotanshinone, etc) as well as hydrophilic constituents (danshensu, salvianolic acid A and B, protocatechuic aldehyde, etc) contribute to the cardiovascular protective actions of Danshen, suggesting a potential synergism among these constituents. Herein, we provide a systematic up-to-date review on the cardiovascular actions and therapeutic potential of major pharmacologically active constituents of Danshen. These bioactive compounds will serve as excellent drug candidates in small-molecule cardiovascular drug discovery. This article also provides a scientific rationale for understanding the traditional use of Danshen in cardiovascular therapeutics.

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Section: Salvianolic Acid Bmentioning

confidence: 99%

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

2018

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“…Salvianolic acid B treatment (0.001, 0.01 and 0.1 mg/mL for 2 h) decreased Ca 2+ and cAMP, and inhibited PKA in H9C2 cell (a myogenic cell line derived from embryonic rat heart ventricle) [79]. …”

Section: Effects Of S Miltiorrhiza and Its Isolated Compounds On Thementioning

confidence: 99%

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

Wang

Liu

et al. 2017

CPD

197

125

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Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases (CVD) in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine (TCM) interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since 2000, 39 clinical trials have been identified that used S. miltiorrhiza in TCM prescriptions alone or with other herbs for the treatment of patients with CVD. More than 200 individual compounds have been isolated and characterized from S. miltiorrhiza, which exhibited various pharmacological activities targeting different pathways for the treatment of CVD in various animal and cell models. The isolated compounds may provide new perspectives in alternative treatment regimes and reveal novel chemical scaffolds for the development of anti-CVD drugs. Meanwhile, there are also some rising concerns of the potential side effects and drug-drug interactions of this plant. The insights gained from this study will help us to better understanding of the actions of this herb for management of cardiovascular disorders. As an herb of red root, S. miltiorrhiza will act as a potential red light to prevent the development of CVD.

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“…Then, adenylate cyclase is activated by Gs, which turns adenosine triphosphate (ATP) to cAMP. The cAMP in turn activates PKA and increases intracellular Ca 2 + concentrations, thereby activating CaM/CaMKII (Lu et al, 2012). In this study, the results indicated that the reduction of CaMKII levels is a negative feedback regulator of cellular Ca 2 + overload, which could reduce the extent of ischemic myocardial injury.…”

Section: Discussionmentioning

confidence: 62%

Dynamic Alterations in the Ca_V1.2/CaM/CaMKII Signaling Pathway in the Left Ventricular Myocardium of Ischemic Rat Hearts

Zhao

Sun

et al. 2014

DNA and Cell Biology

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Cardiac L-type calcium channel (Ca V 1.2), calmodulin (CaM), and Ca 2 + /calmodulin-dependent protein kinase II (CaMKII) form the Ca V 1.2/CaM/CaMKII signaling pathway, which plays an important role in maintaining intracellular Ca 2 + homeostasis. The roles of CaM and CaMKII in the regulation of Ca V 1.2 in Ca 2 + -dependent inactivation and facilitation have been reported; however, alterations in this signaling pathway in the heart after myocardial ischemia (MI) had not been well characterized. In this study, we investigated the dynamic changes in Ca V 1.2, CaM, and CaMKII mRNA and protein expression levels in the left ventricles of the heart following MI in rats. The MI model was induced by ligating the left anterior descending coronary artery; the rats were divided into the following five groups: the 6 h post-MI group (MI-6h), 24 h post-MI group (MI-24h), 1 week post-MI group (MI-1w), 2 weeks post-MI group (MI-2w), and the sham group. The mRNA levels were measured by quantitative real-time polymerase chain reaction and the protein expression was determined by western blotting and immunohistochemistry. There were no observable differences in the Ca V 1.2 mRNA and protein levels at the early stages of MI, but these levels decreased at MI-2w. Both the mRNA and protein levels of CaM increased at MI-6h, peaked at MI-24h, and then reduced to normal levels at MI-2w. CaMKII mRNA and protein levels decreased at MI-6h and reached their lowest level at MI-24h. Taken together, these data demonstrate that there are dynamic changes in the Ca V 1.2/CaM/CaMKII signaling pathway following MI injuries, which suggests that different therapeutic regimens should be used at different time points after MI injuries.

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Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B

Cited by 16 publications

References 28 publications

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

Dynamic Alterations in the Ca_V1.2/CaM/CaMKII Signaling Pathway in the Left Ventricular Myocardium of Ischemic Rat Hearts

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Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B

Cited by 16 publications

References 28 publications

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

Dynamic Alterations in the CaV1.2/CaM/CaMKII Signaling Pathway in the Left Ventricular Myocardium of Ischemic Rat Hearts

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Dynamic Alterations in the Ca_V1.2/CaM/CaMKII Signaling Pathway in the Left Ventricular Myocardium of Ischemic Rat Hearts