Metabolomic profiling of cancer cells to Aloe vera extract by 1HNMR spectroscopy

Noorolahi, Seyedeh Masoomeh; Sadeghi, Sedigheh; Mohammadi, Maryam; Azadi, Mahsa; Rahimi, Nowrooze Ali; Vahabi, Farideh; Arjmand, Mohammad; Hosseini, h; Mosallatpur, Samaneh; Zamani, Zahra

doi:10.7243/2059-0008-2-1

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…f., an anticancer and antitumorigenic plant. The metabolome influences the genome of hepatocellular carcinoma cells by escalating the gene expressions of p53 and Bcl-2 [ 164 ]. The metabolomic characterization of Panax ginseng C. A.…”

Section: Metabolomics In Medicinal Plantsmentioning

confidence: 99%

Crosstalk of Multi-Omics Platforms with Plants of Therapeutic Importance

Pandita¹,

Pandita²,

Wani

et al. 2021

Cells

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From time immemorial, humans have exploited plants as a source of food and medicines. The World Health Organization (WHO) has recorded 21,000 plants with medicinal value out of 300,000 species available worldwide. The promising modern “multi-omics” platforms and tools have been proven as functional platforms able to endow us with comprehensive knowledge of the proteome, genome, transcriptome, and metabolome of medicinal plant systems so as to reveal the novel connected genetic (gene) pathways, proteins, regulator sequences and secondary metabolite (molecule) biosynthetic pathways of various drug and protein molecules from a variety of plants with therapeutic significance. This review paper endeavors to abridge the contemporary advancements in research areas of multi-omics and the information involved in decoding its prospective relevance to the utilization of plants with medicinal value in the present global scenario. The crosstalk of medicinal plants with genomics, transcriptomics, proteomics, and metabolomics approaches will be discussed.

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Section: Metabolomics In Medicinal Plantsmentioning

confidence: 99%

Crosstalk of Multi-Omics Platforms with Plants of Therapeutic Importance

Pandita¹,

Pandita²,

Wani

et al. 2021

Cells

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“…A range of medical combinations may be required to treat patients whose tumors become resistant to chemotherapeutic treatments. Many technologies are presently being tested in clinical trials, particularly nanomedicines, which are also advancing the creation of biocompatible materials for use in cancer treatment and diagnosis, like the creation of novel medications that treat different forms of cancer by utilizing ethnomedicinal plants [10,11]. The use of natural, synthetic, or biological agents that can reverse, suppress, or prevent carcinogenesis or the progression of premalignant cells toward invasive tumors has made cancer chemoprevention an important therapeutic option that may help fight cancer [12,13].…”

Section: Introductionmentioning

confidence: 99%

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

Albahri,

Badran,

Abdel Baki

et al. 2024

Pharmaceuticals

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Globally, cancer is one of the primary causes of both morbidity and mortality. To prevent cancer from getting worse, more targeted and efficient treatment plans must be developed immediately. Recent research has demonstrated the benefits of natural products for several illnesses, and these products have played a significant role in the development of novel treatments whose bioactive components serve as both chemotherapeutic and chemo-preventive agents. Phytochemicals are naturally occurring molecules obtained from plants that have potential applications in both cancer therapy and the development of new medications. These phytochemicals function by regulating the molecular pathways connected to the onset and progression of cancer. Among the specific methods are immune system control, inducing cell cycle arrest and apoptosis, preventing proliferation, raising antioxidant status, and inactivating carcinogens. A thorough literature review was conducted using Google Scholar, PubMed, Scopus, Google Patent, Patent Scope, and US Patent to obtain the data. To provide an overview of the anticancer effects of several medicinal plants, including Annona muricata, Arctium lappa, Arum palaestinum, Cannabis sativa, Catharanthus roseus, Curcuma longa, Glycyrrhiza glabra, Hibiscus, Kalanchoe blossfeldiana, Moringa oleifera, Nerium oleander, Silybum marianum, Taraxacum officinale, Urtica dioica, Withania somnifera L., their availability, classification, active components, pharmacological activities, signaling mechanisms, and potential side effects against the most common cancer types were explored.

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“…Cancer is a leading cause of death worldwide, characterized by abnormal growth of cells which tend to proliferate in an uncontrolled way consequently progressing from a pre-cancerous lesion to a malignant state [ 1 ]. Nearly 2.6 million new cancer cases with 1.7 million deaths per year are projected by 2030.…”

Section: Introductionmentioning

confidence: 99%

“…Any of these Yasmin et al depends on the location, grade, stage as well as the general state of the patient's health. Chemotherapy and radiation therapy destroy normal cells besides killing cancerous cells [1]. Through surgery, solid tumors are removed from the patient's body but with a plethora of side effects which reduce the quality of life.…”

Section: Introductionmentioning

confidence: 99%

“…To meet the demand for anti-cancer drugs with fewer side effects, plants can be a promising source from the point of health perceptive in humans [8]. In addition to these, medicinal plants are widely available, and less expensive with negligible or no toxicity as compared to artificial chemotherapeutic drugs [1]. Several medicinal plants and herbal ingredients have been reported to have anti-cancer effects (Table 1) [9][10][11][12][13][14][15][16][17][18][19][20][21] and some phytochemicals isolated from these plants have been shown to decrease cancer cell proliferation, induce apoptosis, retard metastasis, and inhibit angiogenesis [22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects ofHibiscus sabdariffa: A Review

Yasmin,

Gogoi,

Bora

et al. 2023

J Cancer Prev

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A category of diseases known as cancer includes abnormal cell development and the ability to infiltrate or spread to other regions of the body, making them a major cause of mortality worldwide. Chemotherapy, radiation, the use of cytotoxic medicines, and surgery are the mainstays of cancer treatment today. Plants or products produced from them hold promise as a source of anti-cancer medications that have fewer adverse effects. Due to the presence of numerous phytochemicals that have been isolated from various parts of the Hibiscus sabdariffa (HS) plant, including anthocyanin, flavonoids, saponins, tannins, polyphenols, organic acids, caffeic acids, citric acids, protocatechuic acid, and others, extracts of this plant have been reported to have anti-cancer effects. These compounds have been shown to reduce cancer cell proliferation, induce apoptosis, and cause cell cycle arrest. They also increase the expression levels of the cell cycle inhibitors (p53, p21, and p27) and the pro-apoptotic proteins (BAD, Bax, caspase 3, caspase 7, caspase 8, and caspase 9). This review highlights various intracellular signalling pathways involved in cancer preventive potential of HS.

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Metabolomic profiling of cancer cells to Aloe vera extract by 1HNMR spectroscopy

Cited by 8 publications

References 24 publications

Crosstalk of Multi-Omics Platforms with Plants of Therapeutic Importance

Crosstalk of Multi-Omics Platforms with Plants of Therapeutic Importance

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects ofHibiscus sabdariffa: A Review

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