Metabolomic Profiling of Different Antrodia cinnamomea Phenotypes

Abstract

Antrodia cinnamomea (AC) is a precious medicinal fungus with numerous therapeutic benefits. Based on the color appearance of its fruiting bodies, AC can be divided into red AC (RAC), yellow AC (YAC), and white AC (WAC); however, the differences in their metabolomic profiles remain unknown. This study aimed to analyze the metabolomic profiles of three different AC phenotypes and examine their relationship to the color appearance of fruiting bodies. The results showed that although RAC, YAC, and WAC appear to have a relatively similar profile of index triterpenoids, their total triterpenoid contents were significantly different. Among the annotated triterpenoids, many of them were highly present in RAC but not in YAC and WAC, and the relative contents of the four ergostanes (antcamphin F, antcamphin L, antcin B, and antcin K) and one lanostane (versisponic acid D) were found to be significantly different among AC phenotypes. The metabolomic profiles of the AC fruiting bodies demonstrated a total of 140 metabolites, and 41 of them were very different among AC phenotypes. This study indicates that red, yellow, and white AC can biosynthesize the diverse structures of triterpenoids, and RAC possesses a relatively higher contents of triterpenoids and diverse unannotated metabolites than YAC and WAC.

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

“…The appearance of fruiting bodies is generally red-orange, but in certain regions of Taiwan, rarely yellow and white variants also occur. Metabolomic Profiling indicated that red AC possesses relatively higher contents of triterpenoids and diverse metabolites than yellow AC and white AC ( Su et al, 2023 ).…”

Extraction, isolation, identification, and bioactivity of polysaccharides from Antrodia cinnamomea

“…It features a sporangium on the surface of the fruiting body that contains spores, an uneven surface, and a safrole odor. Based on the color of fruiting bodies, the fungi are classified as red, yellow, and white A. cinnamomea (Su, et al, 2023). Triterpenoids and polysaccharides are the primary active components of A. cinnamomea (He et al, 2019;Liu et al, 2004).…”