2019
DOI: 10.21203/rs.2.13675/v1
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Metabolomic profiling of oral squamous cell carcinoma reveals glutaminolysis-related proteins: GLS1 and GLUD1 are potential diagnostic and prognostic factors

Abstract: It is essential to explore potential molecular involved in oral squamous cell carcinoma (OSCC) malignant transformation and progression. The purpose of this study was to delineate the metabolic characteristics of OSCC patients. We firstly report GC-MS based metabolic profiling of OSCC tissues from 8 patients, including tumor tissues and its matched normal tissues, then another 81 OSCC patients with prognostic information were used to verify metabolomics results by exam key enzymes expression. A panel including… Show more

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