Metabolomic signature of amino acids and polyamines in the serum of osteoarthritis patients

Tootsi, Kaspar; Vilba, Kadri; Märtson, Aare; Kals, Jaak; Paapstel, Kaido; Zilmer, Mihkel

doi:10.1016/j.joca.2021.02.484

Cited by 2 publications

(9 citation statements)

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“…Of the remaining 44 studies, 1 was excluded due to incomplete information, 3 were excluded due to no access to the full text, and 27 were not eligible according to our criteria. At last, 13 studies [38][39][40][41][42][43][44][45][46][47][48][49][50] were included for qualitative synthesis. Of those 13 studies, 4 studies [38,44,47,48] with 495 participant (242 in OA group, 253 in healthy control group) were recruited into the meta-analysis.…”

Section: Literature Searchmentioning

confidence: 99%

“…At last, 13 studies [38][39][40][41][42][43][44][45][46][47][48][49][50] were included for qualitative synthesis. Of those 13 studies, 4 studies [38,44,47,48] with 495 participant (242 in OA group, 253 in healthy control group) were recruited into the meta-analysis. The flow chart is shown in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

“…All of the included studies were published between 2009 and 2022 and designed as case-control studies. Eight studies [43][44][45][46][47][48][49][50] were reported in English and five studies [38][39][40][41][42] in Chinese. The participants were recruited from Spain [46], the UK [43], Estonia [47], Canada [44] and China [38][39][40][41][42]45,[48][49][50].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Eight studies [43][44][45][46][47][48][49][50] were reported in English and five studies [38][39][40][41][42] in Chinese. The participants were recruited from Spain [46], the UK [43], Estonia [47], Canada [44] and China [38][39][40][41][42]45,[48][49][50]. All studies were well-matched by age and sex, except one study [45] that failed to report the age information.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…A total of 39 differential small molecule metabolites were extracted from four studies, of which 17 were reported with accurate concentrations in at least two studies, which enabled a meta-analysis. In the four studies, the concentration information was directly obtained in three articles [38,47,48] and extracted from the box plots by software in one [44]. These metabolites were measured in blood samples, with a concentration unit of µmol/L.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Differential Metabolites in Osteoarthritis: A Systematic Review and Meta-Analysis

Liao,

Han,

Wang

et al. 2023

Nutrients

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(1) Many studies have attempted to utilize metabolomic approaches to explore potential biomarkers for the early detection of osteoarthritis (OA), but consistent and high-level evidence is still lacking. In this study, we performed a systematic review and meta-analysis of differential small molecule metabolites between OA patients and healthy individuals to screen promising candidates from a large number of samples with the aim of informing future prospective studies. (2) Methods: We searched the EMBASE, the Cochrane Library, PubMed, Web of Science, Wan Fang Data, VIP Date, and CNKI up to 11 August 2022, and selected relevant records based on inclusion criteria. The risk of bias was assessed using the Newcastle–Ottawa quality assessment scale. We performed qualitative synthesis by counting the frequencies of changing directions and conducted meta-analyses using the random effects model and the fixed-effects model to calculate the mean difference and 95% confidence interval. (3) Results: A total of 3798 records were identified and 13 studies with 495 participants were included. In the 13 studies, 132 kinds of small molecule differential metabolites were extracted, 58 increased, 57 decreased and 17 had direction conflicts. Among them, 37 metabolites appeared more than twice. The results of meta-analyses among four studies showed that three metabolites increased, and eight metabolites decreased compared to healthy controls (HC). (4) Conclusions: The main differential metabolites between OA and healthy subjects were amino acids (AAs) and their derivatives, including tryptophan, lysine, leucine, proline, phenylalanine, glutamine, dimethylglycine, citrulline, asparagine, acetylcarnitine and creatinine (muscle metabolic products), which could be potential biomarkers for predicting OA.

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Section: Literature Searchmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Differential Metabolites in Osteoarthritis: A Systematic Review and Meta-Analysis

Liao,

Han,

Wang

et al. 2023

Nutrients

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The Molecular Role of Polyamines in Age-Related Diseases: An Update

Jimenez Gutierrez,

Borbolla Jiménez,

Muñoz

et al. 2023

IJMS

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Polyamines (Pas) are short molecules that exhibit two or three amine groups that are positively charged at a physiological pH. These small molecules are present in high concentrations in a wide variety of organisms and tissues, suggesting that they play an important role in cellular physiology. Polyamines include spermine, spermidine, and putrescine, which play important roles in age-related diseases that have not been completely elucidated. Aging is a natural process, defined as the time-related deterioration of the physiological functions; it is considered a risk factor for degenerative diseases such as cardiovascular, neurodegenerative, and musculoskeletal diseases; arthritis; and even cancer. In this review, we provide a new perspective on the participation of Pas in the cellular and molecular processes related to age-related diseases, focusing our attention on important degenerative diseases such as Alzheimerߣs disease, Parkinsonߣs disease, osteoarthritis, sarcopenia, and osteoporosis. This new perspective leads us to propose that Pas function as novel biomarkers for age-related diseases, with the main purpose of achieving new molecular alternatives for healthier aging.

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Metabolomic signature of amino acids and polyamines in the serum of osteoarthritis patients

Cited by 2 publications

References 0 publications

Differential Metabolites in Osteoarthritis: A Systematic Review and Meta-Analysis

Differential Metabolites in Osteoarthritis: A Systematic Review and Meta-Analysis

The Molecular Role of Polyamines in Age-Related Diseases: An Update

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