Metabolomic signature of the postprandial experience

Malagelada, Carolina; Pribić, Teodora; Ciccantelli, Barbara; Cañellas, Nicolau; Gómez, Josep; Amigó, Núria; Accarino, Anna; Correig, X.; Azpiroz, Fernando

doi:10.1111/nmo.13447

Cited by 8 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As in previous studies, meal ingestion affected the profile of circulating metabolites [10,11]. The increase in GLP-1 was of similar magnitude as previously observed [10], but the increase was not statistically significant, probably due to the large inter-individual variability.…”

Section: Discussionsupporting

confidence: 83%

“…The rest of the scales were scored: (a) at 5 min intervals 10 min before the meal, (b) at the end of each ingestion step, (c) at 5 min intervals during the first 20 min after ingestion, and (d) at 10 min intervals up to 60 min after finishing the probe meal (Figure 1). It has been previously shown that these scales detect consistent and reproducible differences in post-prandial sensations induced by various conditioning factors [3,4,5,6,7,8,9], and that perception measurements correlate with changes in circulating metabolites [10,11] and with some objective parameters of brain function measured by functional magnetic resonance [12].…”

Section: Methodsmentioning

confidence: 99%

“…The metabolomic analysis was performed using nuclear magnetic resonance (NMR), as previously described [10,11]. In brief, the concentration of the three different classes of lipoproteins (VLDL, LDL, and HDL), and their composition (content of cholesterol, triglycerides and large, medium and small particles) were determined [13].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Meal Enjoyment and Tolerance in Women and Men

et al. 2019

Self Cite

View full text Add to dashboard Cite

Various conditioning factors influence the sensory response to a meal (inducible factors). We hypothesized that inherent characteristics of the eater (constitutive factors) also play a role. The aim of this proof-of-concept study was to determine the role of gender, as an individual constitutive factor, on the meal-related experience. Randomized parallel trial in 10 women and 10 men, comparing the sensations before, during, and after stepwise ingestion of a comfort meal up to full satiation. Comparisons were performed by repeated Analysis of Covariance (ANCOVA) measures. During stepwise ingestion, satisfaction initially increased up to a peak, and later decreased down to a nadir at the point of full satiation. Interestingly, the amount of food consumed at the well-being peak was lower, and induced significantly less fullness in women than in men. Hence, men required a larger meal load and stronger homeostatic sensations to achieve satisfaction. The same pattern was observed at the level of full satiation: men ate more and still experienced positive well-being, whereas in women, well-being scores dropped below pre-meal level. The effect of gender on the ingestion experience suggests that other constitutive factors of the eater may also influence responses to meals.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Meal Enjoyment and Tolerance in Women and Men

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Biological Response to Meal Ingestion: Gender Differences

et al. 2019

Self Cite

View full text Add to dashboard Cite

In a previous study, we demonstrated that women enjoyed and tolerated lower meal loads than men. Hence, we hypothesized that with the same meal load, their postprandial response is more pronounced than in men. We performed a randomized parallel trial in 12 women and 12 men comparing the postprandial responses to a palatable comfort meal. We measured homeostatic sensations (hunger/satiety, fullness) and hedonic sensations (digestive well-being, mood) on 10 cm scales, vagal tone by heart ratio variability and the metabolomic profile before and after meal ingestion. Gender differences were analyzed by repeated measures ANCOVA. Overall (n = 24), ingestion of the probe meal induced satiation, fullness, digestive well-being and improved mood (main time-effect p ≤ 0.005 for all). Women exhibited a more intense sensory experience, specially more postprandial fullness, than men [main gender-effect F (1, 21) = 7.14; p = 0.014]; hedonic responses in women also tended to be stronger than in men. Women exhibited more pronounced effects on vagal tone [main gender-effect F (1, 21) = 5.5; p = 0.029] and a different lipoprotein response than men. In conclusion, our data indicate that gender influences the responses to meal ingestion, and these differences may explain the predisposition and higher incidence in women of meal-related functional disorders.

show abstract

“…For example, studies combining measurement of sensations and brain activity show that specific changes in brain activity are selectively related to homeostatic or hedonic sensations [3][4][5]. Some of the changes in blood levels of compounds that originate from the food (e.g., glucose, lipids), from the subject (e.g., gut hormones) or from the microbiota metabolism of meal residues are selectively related to specific postprandial sensations [6,7].…”

Section: Meal Ingestion and Digestive Sensationsmentioning

confidence: 99%

Gastrointestinal Contributions to the Postprandial Experience

Livovsky

Azpiroz

2021

Nutrients

Self Cite

View full text Add to dashboard Cite

Foodingestion induces homeostatic sensations (satiety, fullness) with a hedonic dimension (satisfaction, changes in mood) that characterize the postprandial experience. Both types of sensation are secondary to intraluminal stimuli produced by the food itself, as well as to the activity of the digestive tract. Postprandial sensations also depend on the nutrient composition of the meal and on colonic fermentation of non-absorbed residues. Gastrointestinal function and the sensitivity of the digestive tract, i.e., perception of gut stimuli, are determined by inherent individual factors, e.g., sex, and can be modulated by different conditioning mechanisms. This narrative review examines the factors that determine perception of digestive stimuli and the postprandial experience.

show abstract

Metabolomic signature of the postprandial experience

Abstract: Metabolomic changes in the response to a meal may provide an objective index of the postprandial experience, which may have clinical implications in the management of patients with poor meal tolerance or meal-related symptoms.

Cited by 8 publications

References 38 publications

Meal Enjoyment and Tolerance in Women and Men

Meal Enjoyment and Tolerance in Women and Men

Biological Response to Meal Ingestion: Gender Differences

Gastrointestinal Contributions to the Postprandial Experience

Contact Info

Product

Resources

About