Metabolomics—a powerful tool in livestock research

Ashokan, M; Rana, Ekta; Sneha, K.; Namith, C; Kumar, G. S. Naveen; Nizamuddin, Azharuddin; Elango, K.; Jeyakumar, Sakthivel; Ramesha, K. P.

doi:10.1080/10495398.2022.2128814

Cited by 4 publications

(2 citation statements)

References 108 publications

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“…Different from other large animal species [65][66][67], few studies have been performed on the effects of nutrition on metabolomic status in horses using 1 H-NMR [68,69] (Table 5).…”

Section: Metabolomics In Nutritionmentioning

confidence: 99%

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Laus,

Bazzano,

Spaterna

et al. 2024

Metabolites

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Metabolomics can allow for the comprehensive identification of metabolites within biological systems, at given time points, in physiological and pathological conditions. In the last few years, metabolomic analysis has gained popularity both in human and in veterinary medicine, showing great potential for novel applications in clinical activity. The aim of applying metabolomics in clinical practice is understanding the mechanisms underlying pathological conditions and the influence of certain stimuli (i.e., drugs, nutrition, exercise) on body systems, in the attempt of identifying biomarkers that can help in the diagnosis of diseases. Proton Nuclear Magnetic Resonance spectroscopy (1H-NMR) is well tailored to be used as an analytical platform for metabolites’ detection at the base of metabolomics studies, due to minimal sample preparation and high reproducibility. In this mini-review article, the scientific production of NMR metabolomic applications to equine medicine is examined. The research works are very different in methodology and difficult to compare. Studies are mainly focused on exercise, reproduction, and nutrition, other than respiratory and musculoskeletal diseases. The available information on this topic is still scant, but a greater collection of data could allow researchers to define new reliable markers to be used in clinical practice for diagnostic and therapeutical purposes.

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“…Different from other large animal species [65][66][67], few studies have been performed on the effects of nutrition on metabolomic status in horses using 1 H-NMR [68,69] (Table 5).…”

Section: Metabolomics In Nutritionmentioning

confidence: 99%

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Laus,

Bazzano,

Spaterna

et al. 2024

Metabolites

View full text Add to dashboard Cite

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“…However, they cannot reveal the metabolic changes induced after transcription [12]. On the other hand, metabolomics can quantify all small molecule metabolites in an organism [13]. Therefore, the combination of transcriptomics and metabolomics technologies will enable analysis of the molecular regulatory mechanisms of the photocatalytic treatment of bacteria in a more complete way.…”

Section: Introductionmentioning

confidence: 99%

Multi-Omics Study on Molecular Mechanisms of Single-Atom Fe-Doped Two-Dimensional Conjugated Phthalocyanine Framework for Photocatalytic Antibacterial Performance

Diao,

Duan,

Wang

et al. 2024

Molecules

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Currently, photocatalysis of the two-dimensional (2D) conjugated phthalocyanine framework with a single Fe atom (CPF-Fe) has shown efficient photocatalytic activities for the removal of harmful effluents and antibacterial activity. Their photocatalytic mechanisms are dependent on the redox reaction—which is led by the active species generated from the photocatalytic process. Nevertheless, the molecular mechanism of CPF-Fe antimicrobial activity has not been sufficiently explored. In this study, we successfully synthesized CPF-Fe with great broad-spectrum antibacterial properties under visible light and used it as an antibacterial agent. The molecular mechanism of CPF-Fe against Escherichia coli and Salmonella enteritidis was explored through multi-omics analyses (transcriptomics and metabolomics correlation analyses). The results showed that CPF-Fe not only led to the oxidative stress of bacteria by generating large amounts of h+ and ROS but also caused failure in the synthesis of bacterial cell wall components as well as an osmotic pressure imbalance by disrupting glycolysis, oxidative phosphorylation, and TCA cycle pathways. More surprisingly, CPF-Fe could disrupt the metabolism of amino acids and nucleic acids, as well as inhibit their energy metabolism, resulting in the death of bacterial cells. The research further revealed the antibacterial mechanism of CPF-Fe from a molecular perspective, providing a theoretical basis for the application of CPF-Fe photocatalytic antibacterial nanomaterials.

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Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Zheng,

Zhang,

Tang

et al. 2024

Animal Research and One Health

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Rapid body weight gain in broilers overloads the metabolic system of the organism, resulting in leg abnormalities, which seriously affects animal welfare and industry economics. In this study, broilers with normal and deformed leg bones were examined. Serum biochemical indices showed that the serum calcium to phosphorus ratio was extremely decreased in leg deformed group. In addition, abnormal serum lipid levels suggested a disruption in lipid metabolism. Based on widely targeted metabonomic analysis of serum and cartilage tissues, a total of nine differential metabolites (DMs) significantly associated with leg abnormalities and serum calcium and phosphorus levels were screened, including carnitine C16:0, carnitine C18:1, 3‐hydroxymethyl‐L‐tyrosine, cis‐4‐hydroxy‐D‐proline, cis‐L‐3‐hydroxyproline, trans‐4‐hydroxy‐L‐proline, and so on. Pathway analysis revealed that fatty acid degradation and arachidonic acid metabolism were enriched. Analysis of DMs in these two pathways showed that prostaglandin D2, prostaglandin J2, prostaglandin A2, 15‐keto prostaglandin F2α, and Δ12‐prostaglandin J2 significantly differed between the normal and abnormal groups. It was hypothesized that these important metabolic pathways and metabolites were involved in the metabolic regulation of leg abnormalities.

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Metabolomics—a powerful tool in livestock research

Cited by 4 publications

References 108 publications

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Multi-Omics Study on Molecular Mechanisms of Single-Atom Fe-Doped Two-Dimensional Conjugated Phthalocyanine Framework for Photocatalytic Antibacterial Performance

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

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