Metabolomics analysis of an AAA-ATPase Cdc48-deficient yeast strain

Kawarasaki, Tomoyuki; Nakatsukasa, Kunio

doi:10.1016/j.heliyon.2023.e13219

Cited by 2 publications

(1 citation statement)

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“…In budding yeast, CDC48 is an essential gene [ 15 , 16 ]. Under non-permissive conditions, conditional mutants display diverse phenotypes [ 17 – 20 ]. They include cell cycle arrest, dysfunctional ubiquitin-dependent proteolysis, impaired ER membrane fusion and ERAD, abnormal cell morphology, aberrant spindles, aggregation of mitochondria, altered sensitivity to oxidative stress, and changes in the metabolome [ 21 , 22 ].…”

Section: Main Textmentioning

confidence: 99%

Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases

Chu,

Xie,

Payan

et al. 2023

Mol Neurodegeneration

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The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ homeostasis, especially in cells of the nervous system. As part of a large network, VCP collaborates with many cofactors to ensure proteostasis under normal, stress, and disease conditions. A large number of mutations have revealed the importance of VCP for human health. In particular, VCP facilitates the dismantling of protein aggregates and the removal of dysfunctional organelles. These are critical events to prevent malfunction of the brain and other parts of the nervous system. In line with this idea, VCP mutants are linked to the onset and progression of neurodegeneration and other diseases. The intricate molecular mechanisms that connect VCP mutations to distinct brain pathologies continue to be uncovered. Emerging evidence supports the model that VCP controls cellular functions on multiple levels and in a cell type specific fashion. Accordingly, VCP mutants derail cellular homeostasis through several mechanisms that can instigate disease. Our review focuses on the association between VCP malfunction and neurodegeneration. We discuss the latest insights in the field, emphasize open questions, and speculate on the potential of VCP as a drug target for some of the most devastating forms of neurodegeneration.

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