Metabolomics analysis of the potential anticancer mechanism of annonaceous acetogenins on a multidrug resistant mammary adenocarcinoma cell

Ma, Chengyao; Li, Yue; Wu, Han‐Qing; Ji, Junyang; Sun, Qianqian; Song, Yilin; Wang, Shen; Li, Xiang; Chen, Yong; Chen, Jianwei

doi:10.1016/j.ab.2018.04.022

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…Phenolic compounds (Jiménez, Gruschwitz, Schweiggert, Carle, & Esquivel, ; Silva et al., ), vitamin C, carotenoids (Almeida et al., ; Sousa, Vieira, da Silva, & de Lima, ), and annonaceous acetogenins (Bermejo et al., ) have been associated with antineoplastic, antiparasitic, cytotoxic, immunoressive, neurotoxic, and pesticidal effects. All these compounds have been identified as the major bioactive metabolites from soursop, present mainly in the leaves and peels of the fruit (Table ) (Ma et al., ; Solís‐Fuentes, Hernández‐Medel, & Durán‐de‐Bazúa, ). Besides bioactive compounds, soursop bagasse is rich in sodium and cesium, while rather low concentrations of chromium, scandium, bromine, and calcium were detected (de Matuoka e Chiocchetti et al., ).…”

Section: Wastes and Byproducts From Tropical Fruits And Their Currentmentioning

confidence: 99%

Valorization of byproducts from tropical fruits: Extraction methodologies, applications, environmental, and economic assessment: A review (Part 1: General overview of the byproducts, traditional biorefinery practices, and possible applications)

Villacís-Chiriboga

Elst

Camp

et al. 2020

Comp Rev Food Sci Food Safe

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Tropical fruits represent one of the most important crops in the world. The continuously growing global market for the main tropical fruits is currently estimated at 84 million tons, of which approximately half is lost or wasted throughout the whole processing chain. Developing novel processes for the conversion of these byproducts into value‐added products could provide a viable way to manage this waste problem, aiming at the same time to create a sustainable economic growth within a bio‐economy perspective. Given the ever‐increasing concern about sustainability, complete valorization through a bio‐refinery approach, that is, zero waste concept, as well as the use of green techniques is therefore of utmost importance. This paper aims to report the status on the valorization of tropical fruit byproducts within a bio‐refinery frame, via the application of traditional methodologies, and with specific attention to the extraction of phenolics and carotenoids as bioactive compounds. The different types of byproducts, and their content of bioactives is reviewed, with a special emphasis on the lesser‐known tropical fruits. Moreover, the bioactivity of the different types of extracts and their possible application as a resource for different sectors (food, pharmaceutical, and environmental sciences) is discussed. Consequently, this review presents the concepts of tropical fruit biorefineries, and the potential applications of the isolated fractions.

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Section: Wastes and Byproducts From Tropical Fruits And Their Currentmentioning

confidence: 99%

Valorization of byproducts from tropical fruits: Extraction methodologies, applications, environmental, and economic assessment: A review (Part 1: General overview of the byproducts, traditional biorefinery practices, and possible applications)

Villacís-Chiriboga

Elst

Camp

et al. 2020

Comp Rev Food Sci Food Safe

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“…Annonaceous acetogenins (ACGs) are a series of polyketides commonly derived from Annonaceae plants with a broad range of biological activities. Cellular metabolic profiling of adriamycin resistant human mammary adenocarcinoma cells revealed that ACGs could enhance the therapeutic effectiveness of adriamycin on mammary adenocarcinoma by influencing multiple metabolic pathways, including glycerophospholipid, proline, arginine, hypotaurine, taurine, glutamate, glutamine, aspartate, and alanine metabolisms [86]. Dietary catechols could overcome the chemoresistance of melanoma A375 cells to cisplatin via inhibiting GST [87].…”

Section: Amino Acid Metabolismmentioning

confidence: 99%

Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines

Guo

Tan

Chen

et al. 2020

Cancers

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Cancer is a common and complex disease with high incidence and mortality rates, which causes a severe public health problem worldwide. As one of the standard therapeutic approaches for cancer therapy, the prognosis and outcome of chemotherapy are still far from satisfactory due to the severe side effects and increasingly acquired resistance. The development of novel and effective treatment strategies to overcome chemoresistance is urgent for cancer therapy. Metabolic reprogramming is one of the hallmarks of cancer. Cancer cells could rewire metabolic pathways to facilitate tumorigenesis, tumor progression, and metastasis, as well as chemoresistance. The metabolic reprogramming may serve as a promising therapeutic strategy and rekindle the research enthusiasm for overcoming chemoresistance. This review focuses on emerging mechanisms underlying rewired metabolic pathways for cancer chemoresistance in terms of glucose and energy, lipid, amino acid, and nucleotide metabolisms, as well as other related metabolisms. In particular, we highlight the potential of traditional Chinese medicine as a chemosensitizer for cancer chemotherapy from the metabolic perspective. The perspectives of metabolic targeting to chemoresistance are also discussed. In conclusion, the elucidation of the underlying metabolic reprogramming mechanisms by which cancer cells develop chemoresistance and traditional Chinese medicines resensitize chemotherapy would provide us a new insight into developing promising therapeutics and scientific evidence for clinical use of traditional Chinese medicine as a chemosensitizer for cancer therapy.

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“…Metabolomics, a rapidly emerging eld in the omics area, is focused on the qualitative and quantitative analysis of lowmolecular weight metabolites in biouids, tissues, and cells at a specied time in specic environmental conditions. 13 It has become a complementary method to genomics and proteomics, and provides valuable information on small-molecule metabolites and the signaling pathways in various biological processes. 14 Metabolomic approaches have been applied to lung cancer to identify cancer biomarkers and metabolic pathways associated with tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Discovery of potential therapeutic targets for non-small cell lung cancer using high-throughput metabolomics analysis based on liquid chromatography coupled with tandem mass spectrometry

Luo

Lin

et al. 2019

RSC Adv.

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Metabolomics analysis of the potential anticancer mechanism of annonaceous acetogenins on a multidrug resistant mammary adenocarcinoma cell

Cited by 8 publications

References 25 publications

Valorization of byproducts from tropical fruits: Extraction methodologies, applications, environmental, and economic assessment: A review (Part 1: General overview of the byproducts, traditional biorefinery practices, and possible applications)

Valorization of byproducts from tropical fruits: Extraction methodologies, applications, environmental, and economic assessment: A review (Part 1: General overview of the byproducts, traditional biorefinery practices, and possible applications)

Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines

Discovery of potential therapeutic targets for non-small cell lung cancer using high-throughput metabolomics analysis based on liquid chromatography coupled with tandem mass spectrometry

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