2024
DOI: 10.1002/jssc.202400164
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Metabolomics analysis reveals characteristic metabolites in different levels of oxaliplatin‐induced neurotoxicity

Yujiao Hua,
Rong Wang,
Yankui Liu
et al.

Abstract: Oxaliplatin (L‐OHP), a third‐generation platinum‐based anti‐tumor drug, finds widespread application in the first‐line treatment of metastatic colorectal cancer. Despite its efficacy, the drug's usage is curtailed by a litany of side effects, with L‐OHP‐induced peripheral neuropathy (OIPN) being the most debilitating. This condition can be classified into varying degrees of severity. Employing serum metabolomics, a high‐sensitivity, high‐throughput technique, holds promise as a method to identify biomarkers fo… Show more

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