2019
DOI: 10.3390/metabo9030042
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Metabolomics and Communication Skills Development in Children; Evidence from the Ages and Stages Questionnaire

Abstract: We hypothesized metabolomic profiling could be utilized to identify children who scored poorly on the communication component of the Ages and Stages Questionnaire (ASQ); which assesses development in childhood, and to provide candidate biomarkers for autism spectrum disorders (ASD). In a population of three-year-old children, 15 plasma metabolites, were significantly (p < 0.05) different between children who were categorized as having communication skills that were “on schedule” (n = 365 (90.6%)) as compare… Show more

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Cited by 34 publications
(32 citation statements)
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“…Using a quantitative assay for a targeted panel of metabolites, we observed a high correlation between relative abundance and precise concentration (r 2~0 .97) for all tested metabolites except Nacetylserine (r 2 =0.63) ( Figure S1H). Overall, these data expand on previous evidence that the metabolomic profile of ASD and TD populations display differences not only in the gut compartment, but also in circulation, which may affect the levels of metabolites throughout the body, including the brain (46,47).…”
Section: J O U R N a L P R E -P R O O Fsupporting
confidence: 82%
“…Using a quantitative assay for a targeted panel of metabolites, we observed a high correlation between relative abundance and precise concentration (r 2~0 .97) for all tested metabolites except Nacetylserine (r 2 =0.63) ( Figure S1H). Overall, these data expand on previous evidence that the metabolomic profile of ASD and TD populations display differences not only in the gut compartment, but also in circulation, which may affect the levels of metabolites throughout the body, including the brain (46,47).…”
Section: J O U R N a L P R E -P R O O Fsupporting
confidence: 82%
“…Using a quantitative assay for a targeted panel of metabolites, we observed a high correlation between relative abundance and precise concentration ( Figure S2A). Overall, these data expand on previous evidence that the metabolomic profile of ASD and TD populations display differences not only in the gut compartment, but also in circulation, which may affect the levels of metabolites throughout the body, including the brain (44,45).…”
Section: Plasma and Fecal Metabolomes Differ Between Asd And Tdsupporting
confidence: 82%
“…Rachel S. Kelly et al highlighted differences in tyrosine metabolism, tryptophan biosynthesis and endocannabinoid metabolism in a cohort of children, 13% of whom had ASDs. In addition, they hypothesized that metabolomic biomarkers could help to identify children with poor communication skills [ 71 ].…”
Section: Metabolomicsmentioning
confidence: 99%