Metabolomics and fetal alcohol spectrum disorder

Goldberg, Erin; Aliani, Michel

doi:10.1139/bcb-2017-0080

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…In the literature, there are few studies focusing on the differences in the brain metabolite composition in children exposed to alcohol during the fetal period [32]. Some of the reports were consistent with the current findings.…”

Section: H Mrs Examinationsupporting

confidence: 88%

Assessment of the Central Nervous System in Children with Fetal Alcohol Spectrum Disorder (FASD) Using Magnetic Resonance (MR) Techniques

Urbanik

Nardzewska-Szczepanik

Jadczak-Szumiło³

et al. 2023

Applied Sciences

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The study aimed to assess central nervous systems in children diagnosed with Fetal Alcohol Spectrum Disorder (FASD), using the techniques of magnetic resonance (MRI). The analyses considered 200 children, both female and male, aged 6–17 years, diagnosed with FASD, as well as 32 healthy children of both sexes, aged 6–16 years. Brain anomalies as well as linear and surface area measurements of the brain and corpus callosum were assessed. 1H MRS and DWI signals were evaluated in the frontal lobes, basal ganglia, hippocampi, and cerebellum. Several brain anomalies were found in children with FASD. Qualitative assessment showed the thinning of the corpus callosum in 40% of the cases and cerebral ventricular asymmetry in 32% of the children. The mean thickness of the corpus callosum isthmus and the mean length of the corpus callosum were statistically lower in children with FASD. Higher Lip/Cr concentration and DWI values as well as lower NAA/Cr, Cho/Cr, and mI/Cr concentrations were found in multiple studied brain regions. The analysis of the present findings in the study group showed that brain MRI examinations of children with FASD more often identified a decreased corpus callosum and 1H MRS and DWI abnormalities, particularly in the region of basal ganglia.

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Section: H Mrs Examinationsupporting

confidence: 88%

Assessment of the Central Nervous System in Children with Fetal Alcohol Spectrum Disorder (FASD) Using Magnetic Resonance (MR) Techniques

Urbanik

Nardzewska-Szczepanik

Jadczak-Szumiło³

et al. 2023

Applied Sciences

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“…Goldberg et al reviewed the metabolomics studies in FASD and recommends putting more emphasis on omics data profiles, e.g., biological pathways, instead of single metabolite markers. Specific patterns were found for both human (placenta samples) and animals in fatty acid/sphingolipid and amino acid metabolism (namely Tyrosine and Tryptophan) [32]. Bahkireva et al summarized the different biomarkers and their temporal window of detectability [31].…”

Section: Elucidating the Downstream Effects Of Etoh Exposurementioning

confidence: 99%

Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disorders

et al. 2018

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Alcohol exposure during pregnancy affects the development of the fetus in various ways and may lead to Fetal Alcohol Spectrum Disorders (FASD). FASD is one of the leading preventable forms of neurodevelopmental disorders. In the light of prevention and early intervention, knowledge on how ethanol exposure induces fetal damage is urgently needed. Besides direct ethanol and acetaldehyde toxicity, alcohol increases oxidative stress, and subsequent general effects (e.g., epigenetic imprinting, gene expression, and metabolite levels). The current review provides an overview of the existing knowledge about specific downstream pathways for FASD that affects e.g., the SHH pathway, cholesterol homeostasis, neurotransmitter signaling, and effects on the cytoskeleton. Available human data vary greatly, while animal studies with controlled ethanol exposition are only to a certain limit transferable to humans. The main deficits in knowledge about FASD are the lack of pathophysiological understanding and dose-response relationships, together with the lack of reliable biomarkers for either FASD detection or estimation of susceptibility. In addition to single outcome experiments, omics data should be generated to overcome this problem. Therefore, for future studies we recommend holistic data driven analysis, which allows integrative analyses over multiple levels of genetic variation, transcriptomics and metabolomics data to investigate the whole image of FASD development and to provide insight in potential drug targets for intervention.

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“…This metabolism causes levels of acetaldehyde and hydroxyl radicals to increase in tissues where acetaldehyde can be further oxidized to acetate by acetaldehyde dehydro genase. This results in an increase in the respiratory chain's activity, which produces high levels of ROS, which can cause cell damage, lipid peroxidation, and alcohol-mediated in hibition of cell adhesion and can also disrupt growth factors (growth hormone, growth factor insulin-1) [34,35].…”

Section: Metabolism Of Alcoholmentioning

confidence: 99%

Oxidative Effects in Early Stages of Embryo Development Due to Alcohol Consumption

González-Flores,

Márquez,

Casimiro

2024

IJMS

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Alcohol, a widely consumed drug, exerts significant toxic effects on the human organism. This review focuses on its impact during fetal development, when it leads to a spectrum of disorders collectively termed Fetal Alcohol Spectrum Disorders (FASD). Children afflicted by FASD exhibit distinct clinical manifestations, including facial dysmorphism, delayed growth, and neurological and behavioral disorders. These behavioral issues encompass diminished intellectual capacity, memory impairment, and heightened impulsiveness. While the precise mechanisms underlying alcohol-induced fetal damage remain incompletely understood, research indicates a pivotal role for reactive oxygen species (ROS) that are released during alcohol metabolism, inciting inflammation at the cerebral level. Ethanol metabolism amplifies the generation of oxidant molecules, inducing through alterations in enzymatic and non-enzymatic systems responsible for cellular homeostasis. Alcohol consumption disrupts endogenous enzyme activity and fosters lipid peroxidation in consumers, potentially affecting the developing fetus. Addressing this concern, administration of metformin during the prenatal period, corresponding to the third trimester of human pregnancy, emerges as a potential therapeutic intervention for mitigating FASD. This proposed approach holds promise for ameliorating the adverse effects of alcohol exposure on fetal development and warrants further investigation.

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Metabolomics and fetal alcohol spectrum disorder

Cited by 7 publications

References 35 publications

Assessment of the Central Nervous System in Children with Fetal Alcohol Spectrum Disorder (FASD) Using Magnetic Resonance (MR) Techniques

Assessment of the Central Nervous System in Children with Fetal Alcohol Spectrum Disorder (FASD) Using Magnetic Resonance (MR) Techniques

Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disorders

Oxidative Effects in Early Stages of Embryo Development Due to Alcohol Consumption

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