Metabolomics and fluxomics studies in the medicinal plant Catharanthus roseus

Barrales-Cureño, Hebert Jair; Montiel-Montoya, Jorge; Espinoza-Pérez, José; Cortez-Ruiz, Juan Antonio; Lucho-Constantino, Gonzalo Guillermo; Zaragoza-Martínez, Fabiola; Salazar-Magallón, Jesús Antonio; Reyes, César; Lorenzo-Laureano, José; López-Valdez, Luis Germán

doi:10.1016/b978-0-12-819590-1.00003-3

Cited by 6 publications

(4 citation statements)

References 122 publications

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“…This medicinal and ornamental plant is a member of Apocynaceae family and commonly known as pink periwinkle or Madagascar periwinkle [ 54 ]. V. rosea is rich in alkaloids with wide-ranging biological activities and use in treatment of several types of cancers, such as lung, breast, leukemia, acute lymphoblastic leukemia, testicular germ cell tumor, Kaposi sarcoma, Hodgkin's lymphoma follicular lymphoma, ovarian germ cell tumor, retinoblastoma, Ewing sarcoma, and rhabdomyosarcoma [ 54 , 55 ]. Furthermore, V. rosea contains Vinca alkaloids: that are vindesine, vincristine, vinorelbine, and vinblastine [ 56 , 57 ].…”

Section: Major Medicinal Plants With Anticancer Activities and Possib...mentioning

confidence: 99%

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Siddiqui

Jahan

Singh

et al. 2022

BioMed Research International

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Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years. Plants and microbes are the primary and potential sources of natural compounds to fight against cancer. Moreover, researches in the field of plant-based natural compounds have moved towards advanced and molecular level understandings from the last few decades, leading to the development of potent anticancer agents. Also, plants have been accepted as abundant and prosperous sources for the development of novel therapeutic agents for the management and prevention of different cancer types. The high toxicity of some cancer chemotherapy drugs, as well as their unfavorable side effects and drugs resistance, drives up the demand for natural compounds as new anticancer drugs. In this detailed evidence-based mechanistic review, facts and information about various medicinal plants, their bioactive compounds with their potent anticancer activities against different cancers have been gathered, with further approach to represent the molecular mechanism behind the anticancer activity of these plants. This review will be beneficial for investigators/scientists globally involved in the development of natural, safe, effective, and economical therapeutic agents/drugs against various cancers. This might be an important contribution in the field of drug discovery, where drugs can be used alone or in combination to increase the efficacy of newly synthesized drugs.

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Section: Major Medicinal Plants With Anticancer Activities and Possib...mentioning

confidence: 99%

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Siddiqui

Jahan

Singh

et al. 2022

BioMed Research International

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“…In addition, the absorption band observed at 3357 cm −1 suggested the presence of stretching vibrations of the N-H/C-H/O-H bonds of amines, amides, and alcohols. The stretch of bands between 3000 and 3500 cm −1 , in which 3357 cm −1 demonstrated a sharp peak, could mean that the functional groups of flavonoids, caffeic acid, and cinnamic acid and its derivatives in the leaf extract of C. roseus were involved in the creation of the nanoparticles [41,42]. Furthermore, the absorbance band at 728 cm −1 depicted the presence of aromatic monosubstituted groups.…”

Section: Uv-vis Studies Of Synthesised Nanoparticlesmentioning

confidence: 99%

Bio-Fabrication of Cu/Ag/Zn Nanoparticles and Their Antioxidant and Dye Degradation Activities

et al. 2023

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The biological synthesis of nanoparticles with copper, silver, and zinc (Cu, Ag, Zn) is reported in this study, adopting a greener, safe, reliable, and eco-friendly approach by using an aqueous leaf extract of Catharanthus roseus. The synthesised trimetallic nanoparticles were characterised using different characterisation techniques. The UV–visible spectroscopic technique was initially used to assess nanoparticle formation, in which absorption bands were observed at 220, 270, and 370 nm for Cu, Zn, and Ag nanocomposites, respectively. XRD revealed that the average crystalline size of the nanocomposites was 34.67 nm. The roles of reducing and capping/stabilising agents in the synthesis of Cu/Ag/Zn nanoparticles were confirmed by FTIR analysis, and the successful biosynthesis of the same was also confirmed by X-ray energy-dispersive spectroscopy (EDX) analysis. Potential applications of these synthesised trimetallic nanoparticles were evaluated by assessing their antioxidant and catalytic dye degradation activities. The antioxidant activity of the synthesised nanomaterial was studied using the DPPH assay. The catalytic breakdown of the harmful dyes phenol red and eosin yellow was examined using NaBH4 as a reducing agent. The results showed that the nanomaterial’s radical scavenging capacity at 1000 ug/mL was 75.76% and the degradation of these dyes was up to 78% in the presence of NaBH4. Furthermore, the biogenic trimetallic nanomaterial exhibited effective catalytic degradation activity against methyl red and phenol red dyes.

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“…It is important in the body's defense system because it acts as an antioxidant against reactive oxygen species (ROS) [7]. Alkaloids and phenolic compounds are the most important chemical compounds biosynthesized by C. roseus, and the presence of several chemical groups such as polyphenols, alkaloids, steroids, flavonoid glycosides, anthocyanins, and iridoid glycosides is normally found in several plant structures [4,8]. The previous study also tested the antioxidant activity of C. roseus at various concentrations (200, 400, 600, 800, and 1000 g) [2].…”

Section: Anti-agingmentioning

confidence: 99%

"Anti-Aging Potential of Catharanthus Roseus: Literature Review"

Budianto¹

2021

BJSTR

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Catharanthus roseus, also known as Vinca rosea, is a member of the Apocynaceae family. C. roseus parts are used for a variety of medical purposes. Aging is a natural human "aging mosaic" that manifests and follows different trajectories in various organs, tissues, and cells over time. Previous study showed that C. roseus also has a high antioxidant capacity. Antioxidants are free radical scavengers that protect the human body from free radicals by suppressing oxidative chain reactions. Aging is a natural human "aging mosaic" that manifests and follows different trajectories in various organs, tissues, and cells over time Thus, C. roseus could be used as anti-aging properties.

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Metabolomics and fluxomics studies in the medicinal plant Catharanthus roseus

Cited by 6 publications

References 122 publications

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Bio-Fabrication of Cu/Ag/Zn Nanoparticles and Their Antioxidant and Dye Degradation Activities

"Anti-Aging Potential of Catharanthus Roseus: Literature Review"

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