Metabolomics and Microbiomics: New Potential Strategies in Chronic Pain Syndrome

Piras, Cristina; Pintus, Bruno Maria; Noto, Antonio; Evangelista, Maurizio; Fanos, Vassilios; Musu, Mario; Atzori, Luigi; Sardo, Salvatore; Finco, Gabriele

doi:10.2147/jpr.s354516

Cited by 2 publications

(1 citation statement)

References 71 publications

(60 reference statements)

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“…A cluster of taxa represented by Bifidobacterium longum and Faecalibacterium prausnitzii was closely associated with those individuals reporting no pain at 12 weeks post-operation while Megamonas hypermegale , Bacteroides pectinophilus , Ruminococcus bromii, and Roseburia hominis clustered relatively closely in the group of patients fulfilling the criteria for persistent post-operative pain. A previous study has reported a lower relative abundance of Faecalibacterium prausnitzii in patients with fibromyalgia 69 . In agreement with our results, Bifidobacterium longum administration has been shown to reduce pain and inhibit pain behaviour in a rat model of osteroarthritis 70 .…”

Section: Discussionmentioning

confidence: 83%

The gut microbiota in persistent post-operative pain following breast cancer surgery

Masaud,

Collins,

Rubio

et al. 2024

Sci Rep

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Persistent post-surgical pain (PPSP) is defined as pain which continues after a surgical operation in a significant form for at least three months (and is not related to pre-existing painful conditions). PPSP is a common, under-recognised, and important clinical problem which affects millions of patients worldwide. Preventative measures which are currently available include the selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. More recently, a role for the gut microbiota in pain modulation has become increasingly apparent. This study aims to investigate any relationship between the gut microbiota and PPSP. A prospective observational study of 68 female adult patients undergoing surgery for management of breast cancer was carried out. Stool samples from 45 of these patients were obtained to analyse the composition of the gut microbiota. Measures of pain and state-trait anxiety were also taken to investigate further dimensions in any relationship between the gut microbiota and PPSP. At 12 weeks postoperatively, 21 patients (51.2%) did not have any pain and 20 patients (48.8%) reported feeling pain that persisted at that time. Analysis of the gut microbiota revealed significantly lower alpha diversity (using three measures) in those patients reporting severe pain at the 60 min post-operative and the 12 weeks post-operative timepoints. A cluster of taxa represented by Bifidobacterium longum, and Faecalibacterium prausnitzii was closely associated with those individuals reporting no pain at 12 weeks postoperatively, while Megamonas hypermegale, Bacteroides pectinophilus, Ruminococcus bromii, and Roseburia hominis clustered relatively closely in the group of patients fulfilling the criteria for persistent post-operative pain. We report for the first time specific associations between the gut microbiota composition and the presence or absence of PPSP. This may provide further insights into mechanisms behind the role of the gut microbiota in the development of PPSP and could inform future treatment strategies.

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Section: Discussionmentioning

confidence: 83%

The gut microbiota in persistent post-operative pain following breast cancer surgery

Masaud,

Collins,

Rubio

et al. 2024

Sci Rep

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The effects of stress on gut virome: Implications on infectious disease and systemic disorders

Talarico,

Tilocca,

Spagnuolo

et al. 2024

MicrobiologyOpen

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The role of gut microbiota in health and disease is being thoroughly examined in various contexts, with a specific focus on the bacterial fraction due to its significant abundance. However, despite their lower abundance, viruses within the gut microbiota are gaining recognition for their crucial role in shaping the structure and function of the intestinal microbiota, with significant effects on the host as a whole, particularly the immune system. Similarly, environmental factors such as stress are key in modulating the host immune system, which in turn influences the composition of the gut virome and neurological functions through the bidirectional communication of the gut–brain axis. In this context, alterations in the host immune system due to stress and/or dysbiosis of the gut virome are critical factors in the development of both infectious and noninfectious diseases. The molecular mechanisms and correlation patterns between microbial species are not yet fully understood. This literature review seeks to explore the interconnected relationship between stress and the gut virome, with a focus on how this interaction is influenced by the host's immune system. We also discuss how disturbances in this finely balanced system can lead to the onset and/or progression of diseases.

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Metabolomics and Microbiomics: New Potential Strategies in Chronic Pain Syndrome

Cited by 2 publications

References 71 publications

The gut microbiota in persistent post-operative pain following breast cancer surgery

The gut microbiota in persistent post-operative pain following breast cancer surgery

The effects of stress on gut virome: Implications on infectious disease and systemic disorders

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