Metabolomics-derived biomarkers for biosafety assessment of Gd-based nanoparticle magnetic resonance imaging contrast agents

Abstract

With the rapid development of nanotechnology and biomedicine, numerous gadolinium (Gd)-based nanoparticle MRI contrast agents have been widely investigated. With the unique physicochemical properties of nanoparticles and the complexity of...

Lanthanide Inorganic Nanoparticles Enhance Semiconducting Polymer Nanoparticles Afterglow Luminescence for In Vivo Afterglow/Magnetic Resonance Imaging

“…High-field MRI images were subsequently obtained with a 7T MRI scanner. Figure a,b demonstrates that the r1 relaxivities initially increased with the concentration of the NaGdF 4 shell and then decreased, and it is probably seen due to the T2* effect and T1-saturation. − Notably, the assembly with 0.2 mmol of NaGdF 4 (Y@0.2 mmolGd) exhibited the highest r1 relaxivity, prompting its selection for further experimentation.…”

Employing antagonistic C-X-C motif chemokine receptor 4 antagonistic peptide functionalized NaGdF4 nanodots for magnetic resonance imaging-guided biotherapy of breast cancer

“…For instance, one iron oxide nanoparticle (commercial name, Ferumoxytol) has been approved for clinical application by Food and Drug Administration (FDA) USA, and a certain number of nanomedicines (i.e., nanomaterial-based theranostics) are currently under investigation in pre-clinical and/or clinical trial stages 13 . However, there are continuous biosafety concerns on the nanomedicines because many promising nanomedicines are derived from nonbiodegradable inorganic nanoparticles with large size (> 10 nm in diameter), and can retain in body for long time significantly (even more than months) through interactions with mononuclear phagocyte system (MPS) cells (e.g., Kupffer cells) in spleen and liver 21 – 27 . This drawback can be overcome by the development of nanomedicines with renal clearance pathway since they exhibit chemical medicine-like pharmacokinetic profiles (e.g., totally excreted from body within a relatively short period (several hours to several days)), resulting in minimizing uptaken in MPS cells 11 – 13 , 21 , 22 .…”