Metabolomics in Human Milk Research

Slupsky, Carolyn M.

doi:10.1159/000490305

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…The postnatal period is a critical stage for infant’s physiology, accompanied by rapid changes in brain development, and in metabolic, immunologic, intestinal, and physiological systems [1]. Human milk undergoes dynamic changes in composition during lactation to provide all nutrients and other bioactive substrates for optimal infant growth and development, and exclusive breastfeeding (EBF) is recommended during the first 6 months of life [2].…”

Section: Introductionmentioning

confidence: 99%

“…The effects of human milk bioactives on early infant physiology and development are diverse; effects may reach the insulin signaling cascade, the hepatic mitochondrial system, and possibly the mechanistic target of rapamycin (mTOR) signaling pathway, vital to cell growth, protein and lipid synthesis, or lipid and adiposity accumulation and adipogenesis [1,19,20,21,22]. On the other hand, associations of human milk metabolites were also found with maternal phenotype and diet [22,23].…”

Section: Introductionmentioning

confidence: 99%

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Validation and Application of Biocrates AbsoluteIDQ® p180 Targeted Metabolomics Kit Using Human Milk

et al. 2019

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Human-milk-targeted metabolomics analysis offers novel insights into milk composition and relationships with maternal and infant phenotypes and nutritional status. The Biocrates AbsoluteIDQ® p180 kit, targeting 40 acylcarnitines, 42 amino acids/biogenic amines, 91 phospholipids, 15 sphingolipids, and sum of hexoses, was evaluated for human milk using the AB Sciex 5500 QTRAP mass-spectrometer in liquid chromatography-tandem mass-spectrometry (LC-MS/MS) and flow-injection analysis (FIA) mode. Milk (<6 months lactation) from (A) Bangladeshi apparently healthy mothers (body mass index (BMI) > 18.5; n = 12) and (B) Bangladeshi mothers of stunted infants (height-for-age Z (HAZ)-score <−2; n = 13) was analyzed. Overall, 123 of the possible 188 metabolites were detected in milk. New internal standards and adjusted calibrator levels were used for improved precision and concentration ranges for milk metabolites. Recoveries ranged between 43% and 120% (coefficient of variation (CV): 2.4%–24.1%, 6 replicates). Milk consumed by stunted infants vs. that from mothers with BMI > 18.5 was lower in 6 amino acids/biogenic amines but higher in isovalerylcarnitine, two phospholipids, and one sphingomyelin (p < 0.05 for all). Associations between milk metabolites differed between groups. The AbsoluteIDQ® p180 kit is a rapid analysis tool suitable for human milk analysis and reduces analytical bias by allowing the same technique for different specimens. More research is needed to examine milk metabolite relationships with maternal and infant phenotypes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Validation and Application of Biocrates AbsoluteIDQ® p180 Targeted Metabolomics Kit Using Human Milk

et al. 2019

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“…The composition of breast milk is not stable; on the contrary, it undergoes a series of transformations according to the biological age and physiological needs of the infant (5,29,30). It has even been shown that the external environment (geographical location), the internal environment (mode of delivery), the state of mind, and the dietary intake of the mothers can alter the composition of the milk (31)(32) (33).…”

Section: Analysis Of the Documentsmentioning

confidence: 99%

Systematic review and bibliometric analysis of the metabolome found in human breast milk from healthy and gestational diabetes mellitus mothers

Valencia,

Zuluaga,

Franco

et al. 2023

nova

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Introduction. Human breast milk is considered the gold standard of nutrition, giventhat thanks to the diversity in the metabolome it manages to meet the individual needs ofeach infant by providing essential metabolites that contribute to and intervene in optimalgrowth and development. Few factors can modify the composition of breast milk and,simultaneously, its benefits. However, the increase in maternal metabolic diseases such asgestational diabetes mellitus raises the question of whether it can be one of the factors thatcondition the quality and quantity of metabolites contained in breast milk. Objective. Toidentify the metabolome of breast milk from healthy mothers, its influence on the growth and development of the infant, and to recognize those that are altered because of gestatio-nal diabetes mellitus. Methodology. A systematic review was carried out using multiple databases. For the bibliometric analysis, we used the results of Web of Science and Scopusand the Tree of Science and Bibliometrix software.

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“…The first 1000 days of life (from conception to 2 years of age) are extremely important for the proper development and prevention of diseases in the context of metabolic programming [32]. Metabolomics may be a tool that can help to understand the early health programming of infants from birth [37]. The metabolome of human milk is subject to changes depending on various factors.…”

Section: Introductionmentioning

confidence: 99%

Human milk metabolome: Impact of gestational age, lactational stage and maternal diet

Wojcik

Mojska

2022

Rocz Panstw Zakl Hig

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Human breast milk due to its unique composition and the ability to adapt to the needs of the infant, is referred to as the "gold standard". Exclusive breastfeeding is recommended for the first 6 months of a inflant's life. The composition of breast milk and its metabolites is not constant and varies depending on the influence of various factors. Its analysis allows for rational management of infant nutrition. Intermediate and final metabolites of human milk are formed as a result of various metabolic processes in the mammary gland, and their role and the influence of various factors on them are not fully determined in the context of the proper development of infants. Metabolomic studies can be used to identify intermediate and terminal metabolites in breast milk. The aim of the study was to review the current literature on the variability of human milk metabolome depending on factors such as gestational age, lactation stage and mother's diet. A review of current research shows that the composition of human milk metabolome varies depending on various factors. Better understanding of metabolome of breast milk could be crucial in the future programming of metabolic processes in infants, which is crucial in preventing many diseases and maintaining health.

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Metabolomics in Human Milk Research

Cited by 7 publications

References 42 publications

Validation and Application of Biocrates AbsoluteIDQ® p180 Targeted Metabolomics Kit Using Human Milk

Validation and Application of Biocrates AbsoluteIDQ® p180 Targeted Metabolomics Kit Using Human Milk

Systematic review and bibliometric analysis of the metabolome found in human breast milk from healthy and gestational diabetes mellitus mothers

Human milk metabolome: Impact of gestational age, lactational stage and maternal diet

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