2023
DOI: 10.1101/2023.12.06.570507
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Metabolomics of Mouse Embryonic CSF Following Maternal Immune Activation

Boryana Petrova,
Tiara E Lacey,
Andrew J Culhane
et al.

Abstract: The cerebrospinal fluid (CSF) serves various roles in the developing central nervous system (CNS), from neurogenesis to lifelong cognitive functions. Changes in CSF composition due to inflammation can impact brain function. We recently identified an abnormal cytokine signature in embryonic CSF (eCSF) following maternal immune activation (MIA), a mouse model of autism spectrum disorder (ASD). We hypothesized that MIA leads to other alterations in eCSF composition and employed untargeted metabolomics to profile … Show more

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