Metabolomics of Oral/Head and Neck Cancer

Yin, Gaofei; Huang, Jun; Guo, Wei; Huang, Zhigang

doi:10.1007/978-3-030-51652-9_19

Cited by 2 publications

(2 citation statements)

References 88 publications

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“…Metabolic pathway analysis can be performed with benefiting mechanistic explanations of therapeutic targets for metabolism-related diseases. 582 – 584 The altered metabolites are significantly correlated with metabolic pathways and biological processes involved in the disease progression. In addition, the differential metabolites are likely to be one of the most important information to explain the pathogenesis mechanism.…”

Section: Metabolic Pathwaysmentioning

confidence: 99%

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu

Cai

et al. 2023

Sig Transduct Target Ther

228

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Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeutic potentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathways changes as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists have established a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutic target exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-molecule candidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening and treatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.

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Section: Metabolic Pathwaysmentioning

confidence: 99%

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu

Cai

et al. 2023

Sig Transduct Target Ther

228

View full text Add to dashboard Cite

show abstract

“…Metabolomics is a powerful platform that reflects the effects of disease or damage in cells, tissues, or biological fluids since the metabolic phenotype is the interaction of multiple environmental factors in combination with genetic factors [17][18][19][20]. Small changes in gene expression or protein levels are magnified at the metabolite level, which suggests that changes in metabolite levels may provide a clearer reflection of an organism's phenotype compared to changes at the gene and protein level [21]. Metabolomics has been used to identify mechanisms underlying the radiation-damage response in multiple tissue types.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics analysis of pathways underlying radiation-induced salivary gland dysfunction stages

Buss,

De Oliveira Pessoa,

Snider

et al. 2023

PLoS ONE

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Salivary gland hypofunction is an adverse side effect associated with radiotherapy for head and neck cancer patients. This study delineated metabolic changes at acute, intermediate, and chronic radiation damage response stages in mouse salivary glands following a single 5 Gy dose. Ultra-high performance liquid chromatography-mass spectrometry was performed on parotid salivary gland tissue collected at 3, 14, and 30 days following radiation (IR). Pathway enrichment analysis, network analysis based on metabolite structural similarity, and network analysis based on metabolite abundance correlations were used to incorporate both metabolite levels and structural annotation. The greatest number of enriched pathways are observed at 3 days and the lowest at 30 days following radiation. Amino acid metabolism pathways, glutathione metabolism, and central carbon metabolism in cancer are enriched at all radiation time points across different analytical methods. This study suggests that glutathione and central carbon metabolism in cancer may be important pathways in the unresolved effect of radiation treatment.

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Metabolomics of Oral/Head and Neck Cancer

Cited by 2 publications

References 88 publications

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Metabolomics analysis of pathways underlying radiation-induced salivary gland dysfunction stages

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