Metabolomics of testosterone enanthate administration during severe-energy deficit

Stein, Jesse A.; Karl, J Philip; Berryman, Claire E.; Harris, Melissa; Rood, Jennifer; Pasiakos, Stefan M.; Lieberman, Harris R.

doi:10.1007/s11306-022-01955-y

Cited by 4 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data were then exported into MetaboAnalyst (Version 5.0) for analysis (Pang et al, 2021 ). Analyzed baseline samples ( N = 747) containing 1026 compounds (144 or 14% unknown compounds) underwent data processing as previously described (Stein et al, 2022 ). Metabolic features were removed if not detected in > 20% of samples and any remaining missing data were imputed using 1/5 of the minimum value for that feature across all samples.…”

Section: Methodsmentioning

confidence: 99%

Biomarkers of oxidative stress, diet and exercise distinguish soldiers selected and non-selected for special forces training

et al. 2023

Self Cite

View full text Add to dashboard Cite

Introduction The metabolomic profiles of Soldiers entering the U.S. Special Forces Assessment and Selection course (SFAS) have not been evaluated. Objectives To compare pre-SFAS blood metabolomes of Soldiers selected during SFAS versus those not selected, and explore the relationships between the metabolome, physical performance, and diet quality. Methods Fasted blood samples and food frequency questionnaires were collected from 761 Soldiers prior to entering SFAS to assess metabolomic profiles and diet quality, respectively. Physical performance was assessed throughout SFAS. Results Between-group differences (False Discovery Rate < 0.05) in 108 metabolites were detected. Selected candidates had higher levels of compounds within xenobiotic, pentose phosphate, and corticosteroid metabolic pathways, while non-selected candidates had higher levels of compounds potentially indicative of oxidative stress (i.e., sphingomyelins, acylcarnitines, glutathione, amino acids). Multiple compounds higher in non-selected versus selected candidates included: 1-carboxyethylphenylalanine; 4-hydroxy-nonenal-glutathione; α-hydroxyisocaproate; hexanoylcarnitine; sphingomyelin and were associated with lower diet quality and worse physical performance. Conclusion Candidates selected during SFAS had higher pre-SFAS levels of circulating metabolites that were associated with resistance to oxidative stress, higher physical performance and higher diet quality. In contrast, non-selected candidates had higher levels of metabolites potentially indicating elevated oxidative stress. These findings indicate that Soldiers who were selected for continued Special Forces training enter the SFAS course with metabolites associated with healthier diets and better physical performance. Additionally, the non-selected candidates had higher levels of metabolites that may indicate elevated oxidative stress, which could result from poor nutrition, non-functional overreaching/overtraining, or incomplete recovery from previous physical activity.

show abstract

Section: Methodsmentioning

confidence: 99%

Biomarkers of oxidative stress, diet and exercise distinguish soldiers selected and non-selected for special forces training

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation

Lieberman,

Caldwell,

Vartanian

et al. 2023

Psychopharmacology

View full text Add to dashboard Cite

Rationale Behavioral effects of testosterone depend on dose, acute versus sustained formulation, duration of administration, personality, genetics, and endogenous levels of testosterone. There are also considerable differences between effects of endogenous and exogenous testosterone. Objectives This study was the secondary behavioral arm of a registered clinical trial designed to determine if testosterone protects against loss of lean body mass and lower-body muscle function induced by a severe energy deficit typical of sustained military operations. Methods Behavioral effects of repeated doses of testosterone on healthy young men whose testosterone was reduced by severe energy deficit were examined. This was a double-blind, placebo-controlled, between-group study. Effects of four weekly intramuscular injections of testosterone enanthate (200 mg/week, N = 24) or matching placebo (N = 26) were evaluated. Determination of sample size was based on changes in lean body mass. Tasks assessing aggression, risk-taking, competition, social cognition, vigilance, memory, executive function, and mood were repeatedly administered. Results During a period of artificially induced, low testosterone levels, consistent behavioral effects of administration of exogenous testosterone were not observed. Conclusions Exogeneous testosterone enanthate (200 mg/week) during severe energy restriction did not reliably alter the measures of cognition. Study limitations include the relatively small sample size compared to many studies of acute testosterone administration. The findings are specific to healthy males experiencing severe energy deficit and should not be generalized to effects of other doses, formulations, or acute administration of endogenous testosterone or studies conducted with larger samples using tests of cognitive function designed to detect specific effects of testosterone.

show abstract

The “crosstalk” between gut microbiota, metabolites and genes in diet-induced hepatic steatosis mice intervened with Cordyceps guangdongensis polysaccharides

Wang,

Xie,

Yang

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Metabolomics of testosterone enanthate administration during severe-energy deficit

Cited by 4 publications

References 45 publications

Biomarkers of oxidative stress, diet and exercise distinguish soldiers selected and non-selected for special forces training

Biomarkers of oxidative stress, diet and exercise distinguish soldiers selected and non-selected for special forces training

Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation

The “crosstalk” between gut microbiota, metabolites and genes in diet-induced hepatic steatosis mice intervened with Cordyceps guangdongensis polysaccharides

Contact Info

Product

Resources

About