Metabolomics reveals that sulfotransferase 1 may regulate colchicine-induced liver injury

Huang, Ruoyue; Wang, Chunyan; Wu, Zhanxuan E.; Zhao, Qi; Duan, Jingyi; Huang, Wen; Cheng, Yan; Zhu, Beiwei; Li, Fei

doi:10.1016/j.cbi.2023.110776

Cited by 2 publications

(1 citation statement)

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“…SCXK (Sichuan) 2020-034). All animals were acclimated to the experimental environment for 1 week, and finally, the animals were anesthetized with CO 2 and killed [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity

Huang,

Duan,

Huang

et al. 2024

Toxins

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Colchicine, a natural compound extracted from Colchicum autumnale, is a phytotoxin, but interestingly, it also has multiple pharmacological activities. Clinically, colchicine is widely used for the treatment of gouty arthritis, familial Mediterranean fever, cardiovascular dysfunction and new coronary pneumonia. However, overdose intake of colchicine could cause lethal liver damage, which is a limitation of its application. Therefore, exploring the potential mechanism of colchicine-induced hepatotoxicity is meaningful. Interestingly, it was found that CYP1A1 played an important role in the hepatotoxicity of colchicine, while it might also participate in its metabolism. Inhibition of CYP1A1 could alleviate oxidative stress and pyroptosis in the liver upon colchicine treatment. By regulating CYP1A1 through the CASPASE-1-GSDMD pathway, colchicine-induced liver injury was effectively relieved in a mouse model. In summary, we concluded that CYP1A1 may be a potential target, and the inhibition of CYP1A1 alleviates colchicine-induced liver injury through pyroptosis regulated by the CASPASE-1-GSDMD pathway.

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“…SCXK (Sichuan) 2020-034). All animals were acclimated to the experimental environment for 1 week, and finally, the animals were anesthetized with CO 2 and killed [ 38 ].…”

Section: Methodsmentioning

confidence: 99%