Metabolomics, stunting and neurodevelopment

Heuvel, Meta van den

doi:10.1016/j.ebiom.2019.05.067

Cited by 2 publications

(3 citation statements)

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“…Although several earlier trials have studied the impact of maternal antenatal infection control interventions on birth size, [10][11][12] there are no publications on the impact of these interventions on subsequent child growth. For child development, there are data from the ORACLE trial (antibiotics for preterm, prelabour rupture of membranes and preterm labour) from England, in which women experiencing either preterm premature rupture of membranes (PPROM) or spontaneous preterm labour (SPL) were prescribed either erythromycin, amoxycillinclavulanate, both, or neither.…”

Section: Discussionmentioning

confidence: 99%

“…10 There is evidence that adding maternal azithromycin (AZI) treatment during pregnancy reduces the prevalence of preterm birth and fetal and neonatal growth faltering in malaria-endemic areas. 11 12 The impact of these interventions on child development remains unclear. 13 In a trial in Malawi, we showed that intensified antenatal infection control can reduce stunting in infancy and early childhood and improve cognitive development by 5 years of age.…”

Section: Introductionmentioning

confidence: 99%

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Child growth and neurodevelopment after maternal antenatal antibiotic treatment

et al. 2021

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ObjectiveTo assess whether intermittent preventive treatment of pregnant women (IPTp) with sulfadoxine-pyrimethamine (SP) and azithromycin (AZI) in a malaria-endemic area leads to sustained gains in linear growth and development in their offspring.DesignFollow-up study of a randomised trial.SettingMangochi District in rural southern Malawi.Participants1320 pregnant women and their offspring.InterventionsIPTp monthly with SP and twice with AZI (AZI-SP group), monthly with SP but no AZI (monthly SP), or twice with SP (control). No intervention was given to children.Main outcome measuresCognitive performance using Raven’s Coloured Progressive Matrices (CPM) at 13 years of age; mean height and height-for-age Z-score (HAZ), cumulative incidence and prevalence of stunting (HAZ <−2); weight, body mass index, mid-upper-arm circumference and head circumference.ResultsAt approximately 13 years of age, the mean CPM score was 14.3 (SD 3.8, range 6–29, maximum 36), with no differences between groups. Children in the AZI-SP group were on average 0.4 cm (95% CI −0.9 to 1.7, p=0.6) taller than those in the control group. For cumulative incidence of stunting, the HR in the AZI-SP group was 0.72 (95% CI 0.61 to 0.84, p<0.001) compared with the control and 0.76 (95% CI 0.65 to 0.90, p<0.001) compared with the monthly SP groups. There was no intergroup difference in stunting prevalence or anthropometric measurements.ConclusionsIn rural Malawi, maternal intensified infection control during pregnancy reduces offspring’s cumulative incidence of ever being stunted by 13 years of age. In this study, there was no evidence of a positive impact on cognitive performance.Trial registration numberNCT00131235.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Child growth and neurodevelopment after maternal antenatal antibiotic treatment

et al. 2021

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“…The early childhood development (ECD) impacts long-term individual and population health outcomes, including the ability to learn, achievements in school and later life, citizenship, involvement in community activities, and overall quality of life (van den Heuvel, 2019). An estimated 250 million children under five years old in low-income and middle-income countries are at risk of not attaining their developmental potential, leading to an average deficit of 19.8% in adult annual income (Black et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

Padilha,

Keller,

Normando

et al. 2024

Preprint

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Background:The role of circulating metabolites on child development is understudied. We investigated associations between children’s serum metabolome and early childhood development (ECD).Methods:Untargeted metabolomics was performed on serum samples of 5,004 children aged 6-59 months, a subset of participants from the Brazilian National Survey on Child Nutrition (ENANI-2019). ECD was assessed using the Survey of Well-being of Young Children’s milestones questionnaire. The graded response model was used to estimate developmental age. Developmental quotient (DQ) was calculated as the developmental age divided by chronological age. Partial least square regression was used to select metabolites with a variable importance projection ≥ 1.Results:Twenty-eight top-ranked metabolites were included in linear regression models adjusted for child’s nutritional status, diet quality and age. Interaction between these metabolites and child age was tested. Cresol sulfate (β = -0.07; adjusted-p < 0.001), hippuric acid (β = -0.06; adjusted-p < 0.001), phenylacetylglutamine (β = -0.06; adjusted-p < 0.001), and trimethylamine-N-oxide (β = -0.05; adjusted-p = 0.002) showed inverse associations with DQ. We observed opposite directions in the association of DQ for creatinine (for children aged -1 SD: β = -0.05; p =0.01; +1 SD: β = 0.05; p =0.02) and methylhistidine (-1 SD: β = - 0.04; p =0.04; +1 SD: β = 0.04; p =0.03).Conclusion:Serum biomarkers, including dietary and microbial derived metabolites involved in the gut-brain axis, may potentially be used to track children at risk for developmental delays.Funding:Supported by the Brazilian Ministry of Health and Brazilian National Research Council.

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Metabolomics, stunting and neurodevelopment

Cited by 2 publications

References 9 publications

Child growth and neurodevelopment after maternal antenatal antibiotic treatment

Child growth and neurodevelopment after maternal antenatal antibiotic treatment

Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

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