Metabolomics: Towards Understanding Traditional Chinese Medicine

Zhang, Aihua; Sun, Hui; Zhi-gang, Wang; Sun, Wenjun; Wang, Ping; Wang, Xijun

doi:10.1055/s-0030-1250542

Cited by 228 publications

(141 citation statements)

References 88 publications

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“…Using a systemic approach, it applies a "top down" strategy to study the functions and perturbations of a biological system, from the end products of the metabolic network. This endows metabonomics with a holistic view, making it closer to TCM thinking and particularly fit to study pharmacological and toxicological effects of CHM (Lao et al, 2009;Wang et al, 2005Wang et al, , 2011aZhang et al, 2010). Used with a holistic approach, metabonomics has been also exploited to study and characterise Chinese medicine syndromes in several experimental models, recently reviewed (Wang et al, 2011a,b,c;Zhang et al, 2010).…”

Section: Metabolomics and Metabonomicsmentioning

confidence: 99%

“…This endows metabonomics with a holistic view, making it closer to TCM thinking and particularly fit to study pharmacological and toxicological effects of CHM (Lao et al, 2009;Wang et al, 2005Wang et al, , 2011aZhang et al, 2010). Used with a holistic approach, metabonomics has been also exploited to study and characterise Chinese medicine syndromes in several experimental models, recently reviewed (Wang et al, 2011a,b,c;Zhang et al, 2010). Metabonomics involves global low molecular weight metabolite profiling in complex biological fluids or tissues to study downstream homoeostatic perturbations in biochemical pathways.…”

Section: Metabolomics and Metabonomicsmentioning

confidence: 99%

“…Combination of UPLC/MS is often used to obtain the largest possible biochemical profile. All metabolomic and metabonomic studies result in complex multivariate datasets that need computer programmes for visualisation and chemometric as well as bioinformatic methods for interpretation (Zhang et al, 2010). The therapeutic activity of a classical TCM formula, Liu Wei Di Huang Wan (LW), comprising a mixture of Radix Rehmanniae Preparata, Fructus Corni Officinalis, Cortex Moutan Radicis (Paeonia Suffruticosa), Rhizoma Dioscoreae Oppositae, Sclerotium Poriae Cocos and Rhizoma Alismatis Orientalis, was investigated in a rat model of shen yin deficiency, using a metabonomic approach.…”

Section: Metabolomics and Metabonomicsmentioning

confidence: 99%

See 2 more Smart Citations

Omic techniques in systems biology approaches to traditional Chinese medicine research: Present and future

Buriani

García‐Bermejo

Bosisio

et al. 2012

Journal of Ethnopharmacology

158

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Omic techniques have become key tools in the development of systems biology. As the holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new tendencies in Western medicine towards personalised medicine require in-depth knowledge of mechanisms of action and active compounds, the use of omic techniques is crucial for understanding and interpretation of TCM development, especially in view of its expansion in Western countries. In this short review, omic applications in TCM research are reviewed which has allowed some speculation regarding future perspectives for these approaches in TCM modernisation and standardisation. Guidelines for good practice for the application of omics in TCM research are also proposed.

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Section: Metabolomics and Metabonomicsmentioning

confidence: 99%

Section: Metabolomics and Metabonomicsmentioning

confidence: 99%

Section: Metabolomics and Metabonomicsmentioning

confidence: 99%

See 1 more Smart Citation

Omic techniques in systems biology approaches to traditional Chinese medicine research: Present and future

Buriani

García‐Bermejo

Bosisio

et al. 2012

Journal of Ethnopharmacology

158

View full text Add to dashboard Cite

show abstract

“…As a systemic approach, metabolomics adopts a top-down strategy to reflect the function of organisms from terminal symptoms of metabolic networks, and seeks to understand the metabolic changes in a complete system caused by these interventions in a holistic context (Nicholson and Lindon, 2008;Sreekumar et al, 2009). This property acts in concert with the holistic efficacy of TCM, suggesting that metabolomics has the potential to impact our understanding of the theory behind evidence-based TCM (Wang et al, 2011a;Zhang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Future Perspectives of Chinese Medical Formulae: Chinmedomics as an Effector

Wang

Zhang

Sun

2012

OMICS: A Journal of Integrative Biology

Self Cite

159

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Traditional Chinese medicine (TCM) has been used for thousands of years to treat or prevent disease. The health care paradigm has shifted from a focus on disease to TCM therapy with a holistic approach. However, the actual value of TCM has not been fully recognized worldwide due to a lack of scientific approaches to its study. Today omics has become practically available, and resembles TCM in many aspects, and can serve as a key driving force for the translation of the traditional Chinese medical formulae (chinmediformulae) into practice, and will develop and advance the concept of the metabolomics of chinmediformulae (chinmedomics). Chinmedomics seeks to elucidate the therapeutic and synergistic properties and metabolism of chinmediformulae and the involved metabolic pathways using modern analytical techniques. It is an integral part of top-down systems biology, which aims to improve understanding of chinmediformulae. This approach of combining chinmedomics with chinmediformulae with modern health care systems may lead to a revolution in TCM therapy. Although the scientific study of chinmedomics is at an early stage and requires further scrutiny and validation, the approach has major implications to improve the efficacy of chinmediformulae. This article introduces and reviews the concept of chinmedomics, and highlights recent examples of the approach, which are presented for description and discussion.

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“…The evaluation of a herbal medicine's safety and efficacy is required before its clinical use as a complementary and alternative medicine (CAM) in western countries (Miller et al 2004;Murray and Rubel 1992;Calixto 2000;Zhang et al 2010). The conventional pharmacological approach to characterize herbal medicines focuses on the identification and quantification of a single or several bioactive components (Murray and Rubel 1992;Liu et al 2008), however, the complex properties of herbal medicines often render such an approach inadequate (Wang and Ren 2002;Lao et al 2009;Liang et al 2009;Chan 2003).…”

Section: Introductionmentioning

confidence: 99%

Profiling of the charged metabolites of traditional herbal medicines using capillary electrophoresis time-of-flight mass spectrometry

et al. 2011

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The quantification of a small number of bioactive components in herbal medicines is often inadequate when attempting to elucidate a medicine's biological effects. Despite rapid advances in analytical technologies, obtaining comprehensive metabolomic profiles of herbal medicines remains difficult, due to the complexity of natural product mixtures. Toki-Shakuyaku-San is a Chinese medicine used widely to treat gynecological and obstetric disorders, such as infertility, dysmenorrhea, toxemia during pregnancy and neural dysfunction. It consists of Angelica acutiloba Radix (Toki), Cnidium officinale Rhizoma (Senkyu), Paeonia lactiflora Radix (Shakuyaku), Atractylodes lancea Rhizoma (Sojutsu), Alisma orientale Rhizoma (Takusha) and Poria cocos Hoelen (Bukuryo). To elucidate the composition of these herbal medicines individually, we conducted non-targeted profiling analyses of extracts of these herbs using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS), which allows the simultaneous quantification of hundreds of charged metabolites. In total, 737 ± 183.1 (average ± SD) metabolite-derived features were observed, and of these, 119 metabolites were identified. Score plots of principal component analysis (PCA) showed a clear cluster including Shakuyaku, Bukuryo, and Sojutsu, while the other three herbs were distributed over PCA spaces. Loading plots revealed that amino acids and shikimate-derived alkaloids were the predominant metabolite constituents. Hierarchical clustering analysis revealed that few clusters overlapped in the herbal medicines tested. This report is the first demonstration of the characterization of a herbal medicine using large-scale metabolomic analysis, which is complementary to traditional quality control methods.

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Metabolomics: Towards Understanding Traditional Chinese Medicine

Cited by 228 publications

References 88 publications

Omic techniques in systems biology approaches to traditional Chinese medicine research: Present and future

Omic techniques in systems biology approaches to traditional Chinese medicine research: Present and future

Future Perspectives of Chinese Medical Formulae: Chinmedomics as an Effector

Profiling of the charged metabolites of traditional herbal medicines using capillary electrophoresis time-of-flight mass spectrometry

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