“…PUFAs are involved in many physiological functions, including brain and retinal development, aging, memory, synaptic membrane function, photoreceptor function, and neuroprotection (Bazan, 2003(Bazan, , 2006Eady et al, 2014;Hong et al, 2014). Recently, PUFAs such as DHA have been reported to interact with some pain conditions (Figueroa et al, 2013;Torres-Guzman et al, 2014). We recently reported that DHA and/or GW9508, a GPR40 agonist, have suppressive effects on pain behavior elicited by formalin, acetic acid and a complete Freund's adjuvant.…”