2001
DOI: 10.1021/tx000231j
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Metabonomic Investigations into Hydrazine Toxicity in the Rat

Abstract: The systemic biochemical effects of oral hydrazine administration (dosed at 75, 90, and 120 mg/kg) have been investigated in male Han Wistar rats using metabonomic analysis of (1)H NMR spectra of urine and plasma, conventional clinical chemistry, and liver histopathology. Plasma samples were collected both pre- and 24 h postdose, while urine was collected predose and daily over a 7 day postdose period. (1)H NMR spectra of the biofluids were analyzed visually and via pattern recognition using principal componen… Show more

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Cited by 180 publications
(177 citation statements)
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“…It has been reported that hydrazine can cause hepatic lesions and neurotoxicity (Waterfield et al, 1993;Nicholls et al, 2001). The detection of metabolite M16 provided more insight for the study of ATV toxicity.…”
Section: Downloaded Frommentioning
confidence: 99%
“…It has been reported that hydrazine can cause hepatic lesions and neurotoxicity (Waterfield et al, 1993;Nicholls et al, 2001). The detection of metabolite M16 provided more insight for the study of ATV toxicity.…”
Section: Downloaded Frommentioning
confidence: 99%
“…The benzoylation of glycine to form hippurate is colocated with TCA cycle activity in the mitochondria; therefore, it is reasonable that hippurate has dependencies with TCA intermediates 24,38 ANIT low dose cases creatine to citrate, fumarate, hippurate, creatinine and trimethylamine-N-oxide…”
Section: Resultsmentioning
confidence: 99%
“…These metabonomic changes observed in urine and plasma were likely the results of a suppression of the energy metabolism/production and TCA cycle. The effects of hepatotoxicants on endogenous metabolites in mice and rats have been extensively investigated and the following alterations have been reported: a decreased excretion of 2-OG into the urine by α-naphtyl isothiocyanate (ANIT), D-(+)-galactosamine (GalN), buthylated hydroxytoluene (BHT) and HgCl 2 ; and decreased excretion of urinary 2-OG and TMAO by hydrazine, thioacetamide, carbon tetrachloride and allyl alcohol (Beckwith-Hall et al, 1998;Nicholls et al, 2001;Holmes et al, 2000;Gartland et al, 1991;Shockcor and Holmes, 2002;Waters et al, 2001Waters et al, , 2005. Regard- ing APAP-induced hepatotoxicity, it was reported that β-hydroxybutyrate and lactate increased in serum, but…”
Section: Discussionmentioning
confidence: 99%