“…These metabonomic changes observed in urine and plasma were likely the results of a suppression of the energy metabolism/production and TCA cycle. The effects of hepatotoxicants on endogenous metabolites in mice and rats have been extensively investigated and the following alterations have been reported: a decreased excretion of 2-OG into the urine by α-naphtyl isothiocyanate (ANIT), D-(+)-galactosamine (GalN), buthylated hydroxytoluene (BHT) and HgCl 2 ; and decreased excretion of urinary 2-OG and TMAO by hydrazine, thioacetamide, carbon tetrachloride and allyl alcohol (Beckwith-Hall et al, 1998;Nicholls et al, 2001;Holmes et al, 2000;Gartland et al, 1991;Shockcor and Holmes, 2002;Waters et al, 2001Waters et al, , 2005. Regard- ing APAP-induced hepatotoxicity, it was reported that β-hydroxybutyrate and lactate increased in serum, but…”