Metabonomic study of chronic heart failure and effects of Chinese herbal decoction in rats

Guo, Na; Yang, Dawei; Wang, Xiaoxing; Dai, Jingang; Wang, Mei; Yan, Lei

doi:10.1016/j.chroma.2014.08.028

Cited by 42 publications

(27 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Qili qiangxin capsule, a traditional Chinese medicine, has been approved in China to be used in combination therapy for chronic HF 34. Of note, several other traditional Chinese medicines such as Huangqi injection, Berberine, Shenfu decoction, Shengmai, Hawthorn, Curcumin, Resveratrol and Cannabinoids may have potential therapeutic use in HF as adjunctive treatments in clinical practice or animal models of human disease 31, 37, 38, 39, 40. All these findings manifest that herbal medicine products play more and more important role in modern medical therapy.…”

Section: Discussionmentioning

confidence: 99%

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Zhang

Niu

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

MicroRNA‐1 (miR‐1) stands out as the most prominent microRNA (miRNA) in regulating cardiac function and has been perceived as a new potential therapeutic target. Lycium barbarum polysaccharides (LBPs) are major active constituents of the traditional Chinese medicine based on L. barbarum. The purpose of this study was to exploit the cardioprotective effect and molecular mechanism of LBPs underlying heart failure. We found that LBPs significantly reduced the expression of myocardial miR‐1. LBPs improved the abnormal ECG and indexes of cardiac functions in P‐V loop detection in transgenic (Tg) mice with miR‐1 overexpression. LBPs recovered morphological changes in sarcomeric assembly, intercalated disc and gap junction. LBPs reversed the reductions of CaM and cMLCK, the proteins targeted by miR‐1. Similar trends were also obtained in their downstream effectors including the phosphorylation of MLC2v and both total level and phosphorylation of CaMKII and cMyBP‐C. Collectively, LBPs restored adverse structural remodelling and improved cardiac contractile dysfunction induced by overexpression of miR‐1. One of the plausible mechanisms was that LBPs down‐regulated miR‐1 expression and consequently reversed miR‐1‐induced repression of target proteins relevant to myocardial contractibility. LBPs could serve as a new, at least a very useful adjunctive, candidate for prevention and therapy of heart failure.

show abstract

Section: Discussionmentioning

confidence: 99%

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Zhang

Niu

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…studied the therapeutic effects of shenfu decoction in urine samples from rats with chronic heart failure and detected 16 TCA cycle metabolites whose levels are altered by treatment with the above decoction. These included citrate and L-tyrosine, and L-tryptophan, the latter two of which are related to tyrosine and tryptophan metabolism [39]. In this study of SFZYD decoction, we identified 27 metabolites whose expression level changes correlated with changes in biomarker networks after SFZYD treatment in systemic inflammation and hepatic steatosis.…”

Section: Discussionmentioning

confidence: 99%

Shaofu Zhuyu decoction ameliorates obesity-mediated hepatic steatosis and systemic inflammation by regulating metabolic pathways

et al. 2017

View full text Add to dashboard Cite

Shaofu Zhuyu decoction (SFZYD, also known as Sobokchugeo-tang), a classical prescription drug in traditional East Asian medicine, has been used to treat blood stasis syndrome (BSS). Hepatic steatosis is the result of excess caloric intake, and its pathogenesis involves internal retention of phlegm and dampness, blood stasis, and liver Qi stagnation. To evaluate the effects of treatment with SFZYD on obesity-induced inflammation and hepatic steatosis, we fed male C57BL/6N mice a high fat diet (HFD) for 8 weeks and then treated them with SFZYD by oral gavage for an additional 4 weeks. The results of histological and biochemical examinations indicated that SFZYD treatment ameliorates systemic inflammation and hepatic steatosis. A partial least squares-discriminant analysis (PLS-DA) scores plot of serum metabolites showed that HFD mice began to produce metabolites similar to those of normal chow (NC) mice after SFZYD administration. We noted significant alterations in the levels of twenty-seven metabolites, alterations indicating that SFZYD regulates the TCA cycle, the pentose phosphate pathway and aromatic amino acid metabolism. Increases in the levels of TCA cycle intermediate metabolites, such as 2-oxoglutaric acid, isocitric acid, and malic acid, in the serum of obese mice were significantly reversed after SFZYD treatment. In addition to inducing changes in the above metabolites, treatment with SFZYD also recovered the expression of genes related to hepatic mitochondrial dysfunction, including Ucp2, Cpt1α, and Ppargc1α, as well as the expression of genes involved in lipid metabolism and inflammation, without affecting glucose uptake or insulin signaling. Taken together, these findings suggest that treatment with SFZYD ameliorated obesity-induced systemic inflammation and hepatic steatosis by regulating inflammatory cytokine and adipokine levels in the circulation and various tissues. Moreover, treatment with SFZYD also reversed alterations in the levels of metabolites of the TCA cycle, the pentose phosphate pathway and aromatic amino acid metabolism.

show abstract

“…From the perspective of TCM, CHF may occur in all differentiation types, including qi deficiency and blood stasis, yang deficiency and water retention, yin deficiency, and so on. Many Chinese herbs have demonstrated safety and efficacy in the management of chronic heart failure in either animal models or humans [42,43]. In addition, modern biologic research has entered an era of integrating various research technologies and methods to tackle difficult biological problems at biomolecular level as a whole, which is exemplified by studies in the new scientific fields of metabolomics.…”

Section: Diagnostic Power Of Metabolomics In Tcm Syndromes Of Chfmentioning

confidence: 99%

Application of Metabolomics for the Diagnosis and Traditional Chinese Medicine Syndrome Differentiation of Chronic Heart Failure

Wang¹,

Chen²,

Zhao³

et al. 2016

Metabolomics - Fundamentals and Applications

View full text Add to dashboard Cite

Chronic heart failure CHF was characterized by the failure of enough blood supply from the heart to meet the body's metabolic demands, and the prevalence of CHF continuously increases globally. The personalized diagnosis of Traditional Chinese Medicine TCM classiies CHF into several diferent syndrome types, and integrating Western and TCM to treat CHF has proved a validated therapeutic approach. Over the last few years, there has been a rapidly growing number of metabolomics applications aimed at inding biomarkers that could assist diagnosis, provide therapy guidance, and evaluate response to therapy for individualized intervention of CHF. Thus, in this review, particular atention will be paid to the past successes in applications of state-ofthe-art technology on metabolomics to contribute to biomarker discovery in CHF research.Keywords: metabolomics, chronic heart failure, Chinese Medicine . IntroductionChronic heart failure CHF , a progressive clinical syndrome characterized by the inability of the heart to adequately pump blood to meet metabolic demands of the body, represents the inal common ground of pathogenesis wherein various causes of heart damage converge [ ].© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Despite a substantial improvement in the survival rate after the onset of CHF due to increasing use of pharmacological interventions, mortality of patients sufering from CHF remains high. Since it has been well recognized that the incidence and prevalence of CHF are expected to further increase with the aging of the population, beter strategy for the prevention and treatment of CHF patients is still needed. . . Epidemiology of CHFCHF, in recent years, has been a major cause of morbidity and mortality in the general population [ ]. "oth the increasing age of the population and success in the treatment of patients with acute myocardial infarction raise the prevalence and thus the economic expenditures of chronic heart failure [ ]. Heart failure is not only a common, costly, disabling, and potentially fatal condition but also the leading cause of hospitalization in people older than [ ]. In developing countries, % of the population sufers from heart failure, but in people from to years old, it occurs in % [ ]. In developed countries, around % of adults sufer from heart failure, but in people older than , this increases to % [ ]. . . Personalized intervention of CHF based on Traditional Chinese Medicine TCM syndromeWith progress being made in bioinformatics and m...

show abstract

Metabonomic study of chronic heart failure and effects of Chinese herbal decoction in rats

Cited by 42 publications

References 45 publications

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Shaofu Zhuyu decoction ameliorates obesity-mediated hepatic steatosis and systemic inflammation by regulating metabolic pathways

Application of Metabolomics for the Diagnosis and Traditional Chinese Medicine Syndrome Differentiation of Chronic Heart Failure

Contact Info

Product

Resources

About