Metabonomic Understanding of Probiotic Effects in Humans With Irritable Bowel Syndrome

Hong, Young Shick; Hong, Kyoung Sup; Park, Min Hwa; Ahn, Young Tae; Lee, Jun Young; Huh, Chul Sung; Lee, Jaekyung; Kim, In Kyoung; Hwang, Gwi Seo; Kim, Joosung

doi:10.1097/mcg.0b013e318207f76c

Cited by 56 publications

(61 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Significant pain alleviation was not found in 16 studies (6,19,20,(22)(23)(24)(25)(26)29,32,34,(36)(37)(38)(39), although a pain alleviation trend was found in 4 studies (5,23,32,37). Both the TG and Studies identified from bibliographic databases n = 252…”

Section: Abdominal Pain or Discomfortmentioning

confidence: 99%

“…Eighteen studies evaluated the effects of probiotics on distension (4,5,(19)(20)(21)(22)(23)(24)(25)27,(29)(30)(31)(34)(35)(36)(37)39 (19,20,25,29,31,34,36,39).…”

Section: Abdominal Bloating or Distensionmentioning

confidence: 99%

“…REV ESP ENFERM DIG 2013; 105 (1): [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] CG improved during the intervention in 5 studies that reported data analyzing individual pain improvement for each of the groups before and after the study (6,24,25,29,34), with the exception of 1 study in which the TG improved but not the CG (24). Probiotics significantly improved pain in 6 studies (4,21,28,30,33,35), 2 of which provided data of individual pain improvement for each of the groups before and after the study period.…”

Section: Abdominal Pain or Discomfortmentioning

confidence: 99%

See 2 more Smart Citations

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis

Ortiz-Lucas

Tobías

Saz

et al. 2013

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Background and objectives: immune system alteration in irritable bowel syndrome (IBS) patients may be modulated by probiotics. We assessed the efficacy of some probiotic species in alleviating characteristic IBS symptoms.Material and methods: a meta-analysis of all identified randomized controlled trials comparing probiotics with placebo in treating IBS symptoms was performed with continuous data summarized using standardized mean differences (SMDs) with 95% confidence intervals (95% CIs), where appropriate. The random-effects model was employed in cases of heterogeneity; otherwise, fixed-effects models were used.Results: meta-analysis was performed with 10 of 24 studies identified as suitable for inclusion. Probiotics improved pain scores if they contained Bifidobacterium breve (SMD, -0.34; 95% CI, -0.66; -0.02), Bifidobacterium longum (SMD, -0.48; 95% CI, -0.91; -0.06), or Lactobacillus acidophilus (SMD, -0.31; 95% CI, -0.61; -0.01) species. Distension scores were improved by probiotics containing B. breve (SMD, 95% CI, Conclusions: some probiotics are an effective therapeutic option for IBS patients, and the effects on each IBS symptom are likely species-specific. Future studies must focus on the role of probiotics in modulating intestinal microbiota and the immune system while considering individual patient symptom profiles. INTRODUCTIONDefining and treating irritable bowel syndrome (IBS) can be challenging. Among the wide variety of treatment options, probiotics appear to be one of the best options (1). Recently, growing evidence has suggested an alteration in the immune system cell profile of IBS patients and a close relationship between the immune and nervous systems (2,3). Furthermore, several authors have studied the relationship between probiotic intake and blood cytokine levels (4) or changes in fecal microbiota (5,6). Several reviews and meta-analyses that have evaluated the role of probiotics in IBS therapy have concluded that probiotics appear to improve overall IBS symptoms (7-12). However, a meta-analysis that includes any probiotic in the evaluation of symptom relief may not be the best method for assessing the efficacy of specific probiotics (11-13). Therefore, we assessed the efficacy of each specific probiotic species in alleviating characteristic IBS symptoms. Effect of probiotic species on irritable bowel ORIGINAL PAPERSOrtiz-Lucas M, Tobias A, Saz P, Sebastián JJ. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Rev Esp Enferm

show abstract

Section: Abdominal Pain or Discomfortmentioning

confidence: 99%

“…Eighteen studies evaluated the effects of probiotics on distension (4,5,(19)(20)(21)(22)(23)(24)(25)27,(29)(30)(31)(34)(35)(36)(37)39 (19,20,25,29,31,34,36,39).…”

Section: Abdominal Bloating or Distensionmentioning

confidence: 99%

Section: Abdominal Pain or Discomfortmentioning

confidence: 99%

See 1 more Smart Citation

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis

Ortiz-Lucas

Tobías

Saz

et al. 2013

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

show abstract

“…Немногие нежела-тельные явления были зарегистрированы в обеих груп-пах пробиотиков и плацебо [83]. Те же результаты были достигнуты с помощью обширного обзора других 9 иссле-дований, в которые, в соответствии с критериями «Рим II» или «Рим III», были включены 324 пациента с различны-ми типами СРК [84,85].…”

unclassified

Irritable Bowel Syndrome and Its Relationship With Intestinal Microflora

Плотникова¹,

Захарова²,

Сухих³

et al. 2017

Med. sov.

View full text Add to dashboard Cite

В последнее десятилетие наблюдается очень активное изучение огромного микробного сообщества, которое находится в кишечнике человека. Появилась концепция, объясняющая развитие и персистирование симптомов при синдроме раздра-женного кишечника за счет нарушения кишечного микробного пейзажа. Манипулирование микрофлорой кишечника представляет новую стратегию для лечения этого полиэтиологического заболевания. Модулирование кишечной бактери-альной композиции -при этом увеличиваются полезные (Lactobacilli и Bifidobacteria) и сокращаются патогенные бактерии (Clostridium, Escherichia coli, Salmonella, Shigella и Pseudomonas) -должно уменьшать симптомы синдрома раздраженно-го кишечника. В этой концептуальной основе пробиотики являются оптимальным вариантом с точки зрения эффектив-ности и безопасности, а также особое внимание специалистов привлекают пребиотики, синбиотики, антибиотики и фекаль-ная трансплантация.

show abstract

“…1 H NMR spectroscopy can be available detailed information on the concentration of the low-molecular weight metabolites in body fluids such as serum, plasma and urine in a single experiment [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

A Metabonomics Study on Celiac Disease by CART

Fathi¹,

Ektefa²,

Sohrabzadeh³

et al. 2016

IJCD

View full text Add to dashboard Cite

Celiac disease (CD) is an immune reaction as a consequence of ingestion of gluten. Diagnosis of CD is not easily using the clinical tests. Then, the discovery of appropriate methods for CD diagnosis is necessary. This study was concentrated to seek the metabolic biomarkers causes of CD compare to healthy subjects.In the present study, we classify CD and healthy subjects using classification and regression tree (CART). To find metabolites in serum which are helpful for the diagnosis of CD, the metabolic profiling was employed using the proton nuclear magnetic resonance spectroscopy ( 1 HNMR). Based on CART results, it was concluded that just using one descriptor, CD and control groups could be classified separately. The 89 % of data in the test set was predicted correctly by the obtained classification model. Our study indicates that quantitative metabolite analysis of serum can be employed to distinguish healthy from CD subjects.

show abstract

Metabonomic Understanding of Probiotic Effects in Humans With Irritable Bowel Syndrome

Cited by 56 publications

References 0 publications

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis

Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis

Irritable Bowel Syndrome and Its Relationship With Intestinal Microflora

A Metabonomics Study on Celiac Disease by CART

Contact Info

Product

Resources

About