Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury in dimethylnitrosamine treated rats

Sun, Changhai; Teng, Yuanwen; Li, Guangzhi; Yoshioka, Saburo; Yokota, Junko; Miyamura, Mitsuhiko; Hong-zhuang, Fang; Zhang, Yu

doi:10.1016/j.jpba.2010.03.015

Cited by 47 publications

(25 citation statements)

References 23 publications

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“…This research strategy is well coincident with the integrity and systemic feature of TCM. Recently, it has been increasingly used as a versatile tool for assessing therapeutic effects and toxic effects of many herbal TCM and TCM prescriptions (Gu et al, 2010;Ma et al, 2010;Sun et al, 2010;Lu et al, 2011). A number of analytical tools have been currently employed including 1 H NMR spectroscopy (Zhao et al, 2010), LC/MS (Lai et al, 2009), CE/MS (Balderas et al, 2010) and GC/MS .…”

Section: Introductionmentioning

confidence: 99%

Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography–tandem mass spectrometry

Liu

Zhang

et al. 2012

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography–tandem mass spectrometry

Liu

Zhang

et al. 2012

Journal of Ethnopharmacology

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“…It can reveal various metabolic characteristics of normal, pathological or drug-administrated subjects and be used to study the mechanism of drugs action (Zhao et al, 2008;Sun et al, 2010). Since traditional Chinese medicine (TCM) is based on "holism" philosophy instead of "reductionism", it is philosophically conceivable that metabonomic techniques may play some roles in providing important information to TCM (Qiu, 2007).…”

Section: Introductionmentioning

confidence: 99%

A plasma metabonomic investigation into the intervention of volatile oil of Magnolia biondii Pamp on rat model of acute inflammation

et al. 2011

Journal of Ethnopharmacology

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“…9) In this study, we concentrated a urine odor and analyzed it with GC-MS. We examined whether we could identify bladder cancer by GC-MS-based metabolomics analysis.…”

Section: Abstract Metabolomics; Urine Odor; Bladder Cancer; Gc-msmentioning

confidence: 99%

Metabolomics Study on the Biochemical Profiles of Odor Elements in Urine of Human with Bladder Cancer

Jobu

Sun

Yoshioka

et al. 2012

Biological & Pharmaceutical Bulletin

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It has been reported that dogs are capable of identifying cancer in humans by detecting a specific odor: bladder cancer by detecting urine odor and other cancers by detecting exhaled breath odor. However, no odor recognized by dogs that indicates cancer has been identified. In this study, we examined whether bladder cancer could be detected by gas chromatography-mass spectrometry (GC-MS)-based metabolomics analysis of urine odor. Nine patients with bladder cancer and 7 healthy controls were recruited as participants. Patients collected urine 3 d before and for 3-7 d after surgery. The concentrated urine odor was analyzed by GC-MS and principal component analysis (PCA). Results indicated 12 metabolites of urine odor. Score plots of 7 of the preoperative bladder cancer patients were clearly different from those of controls on the PCA map. The distribution of controls was in the negative domain of principal component (PC) 1, whereas the distribution of preoperative patients was in the positive domain of PC1. Bladder cancer was diagnosed in 5 of the 9 patients on the basis of urinary cytology. The findings indicate the potential to screen bladder cancer by analyzing urine odor. Moreover, diagnosis of bladder cancer on the basis of urine odor might have higher sensitivity than screening by urinary cytology. Key words metabolomics; urine odor; bladder cancer; GC-MSThe annual incidence of bladder cancer in men and women is showing a gradual tendency to increase. 1) Urinary tract epithelial cancer is the main bladder cancer and is conventionally detected by hematuria. Screening examinations include urinary cytology, and imaging by cystoscopy, and definitive pathological diagnosis is made by transurethral bladder biopsy. But they have high invasiveness. The bladder cancer is classified roughly into a permeative cancer of the intramural muscular layer and a superficial (muscular layer non-permeation) bladder cancer. When permeative cancer of bladder was discovered, a patient needs all bladder enucleation which is normal treatment that causes urinary passage change. Decline of the quality of life (QOL) is an important problem for patients. On the other hand, when superficial bladder cancer was discovered, a transurethral resection of bladder tumor (TURBT) is considered first-choice treatment. By receiving TURBT, the patient can still keep the bladder. Survival rates for five years of the patient become more than 95%. The life convalescence of the patient is good, too.2) However, many patients have a relapse of a cancer intravesically after a surgery early. It becomes necessary to perform the enforcement of the bladder cancer screening examinations including a purpose to detect a recurrence frequently. For such a reason, the physical, mental and financial burden for the patient is big, and development of the noninvasive screening is urgent business. Therefore, we decided to develop a new screening system for indentifying urinary tract epithelial cancer by metabolomics analysis of urinary odor.The identification of bladder c...

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Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury in dimethylnitrosamine treated rats

Cited by 47 publications

References 23 publications

Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography–tandem mass spectrometry

Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography–tandem mass spectrometry

A plasma metabonomic investigation into the intervention of volatile oil of Magnolia biondii Pamp on rat model of acute inflammation

Metabolomics Study on the Biochemical Profiles of Odor Elements in Urine of Human with Bladder Cancer

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